Chromatin remodeling in oligodendrogenesis
Вавиловский журнал генетики и селекции, 2021 Oligodendrocytes are one type of glial cells responsible for myelination and providing trophic support for axons in the central nervous system of vertebrates.
E. V. Antontseva, N. P. Bondar
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The roles of chromatin remodeling and 3D genome organization in cancers: from mechanistic insights to emerging treatment options [PDF]
Molecular CancerChromatin remodeling comprises a set of molecular mechanisms that regulate gene transcription, DNA replication, and DNA repair by altering nucleosome structure. Previous studies have found that chromatin remodelers are heavily mutated in cancer patients,
Chuqiao Luo +13 more
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Epigenetic and chromatin remodeling mechanisms across cardiomyopathies: a comprehensive review [PDF]
Epigenetics & ChromatinCardiomyopathies constitute a heterogeneous group of myocardial disorders representing leading causes of heart failure and cardiovascular mortality worldwide.
Prabin Upadhyaya
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O-SNAP uncovers nanoscale chromatin remodeling in dedifferentiation and stress responses [PDF]
Nature CommunicationsThe multi-scale organization of chromatin underlies gene regulation and cell identity, yet how nuclear architecture remodels during cell state transitions remains poorly understood. Here, we use single-molecule localization microscopy and a comprehensive
Hannah H. Kim +10 more
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Chromatin Remodeling, DNA Double-Strand Break Repair, and Human Disease: How a Breakup Changes You [PDF]
BiomoleculesChromatin architecture is a central determinant of genomic stability. Effective DNA repair requires dynamic chromatin remodeling to grant repair factors timely access to lesions and to orchestrate repair pathway choice. Disruption of chromatin-regulatory
Adriana Chiaramida +2 more
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Chromatin remodelers in oligodendroglia [PDF]
Glia, 2020 AbstractOligodendrocytes, the myelinating cells in the vertebrate central nervous system, produce myelin sheaths to enable saltatory propagation of action potentials. The process of oligodendrocyte myelination entails a stepwise progression from precursor specification to differentiation, which is coordinated by a series of transcriptional and ...
Carlos Parras +3 more
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER<sup>+</sup> breast cancer. [PDF]
Mol OncolEstrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Johnson Thomas AL +16 more
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Frontiers in Cellular and Infection Microbiology, 2022 Intracellular pathogens manipulate the host cell for their own survival by contributing to modifications of host epigenome, and thus, altering expression of genes involved in the pathogenesis.
Harsimran Kaur Brar +5 more
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Live-cell visualisation of chromatin for the study of radiation-induced chromosome aberrations [PDF]
, 2011 This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.Chromosomes can be visualised during the metaphase stage of the cell cycle however, there are various limitations associated with the visualisation of ...
Malis, Georgios
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The chromatin remodeler SPLAYED regulates specific stress signaling pathways. [PDF]
PLoS Pathogens, 2008 Organisms are continuously exposed to a myriad of environmental stresses. Central to an organism's survival is the ability to mount a robust transcriptional response to the imposed stress. An emerging mechanism of transcriptional control involves dynamic
Justin W Walley +6 more
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