Results 11 to 20 of about 680,917 (346)
Chromatin remodeling in oligodendrogenesis
Вавиловский журнал генетики и селекции, 2021 Oligodendrocytes are one type of glial cells responsible for myelination and providing trophic support for axons in the central nervous system of vertebrates.
E. V. Antontseva, N. P. Bondar
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Biophysics of Chromatin Remodeling
Annual Review of Biophysics, 2021 As primary carriers of epigenetic information and gatekeepers of genomic DNA, nucleosomes are essential for proper growth and development of all eukaryotic cells. Although they are intrinsically dynamic, nucleosomes are actively reorganized by ATP-dependent chromatin remodelers.
Ilana M, Nodelman, Gregory D, Bowman
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Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes
Cell, 2018 SUMMARY Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling complexes are multi-subunit molecular machines that play vital roles in regulating genomic architecture and are frequently disrupted in human cancer and developmental disorders.
Nazar Mashtalir +2 more
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Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies
Trends in Genetics, 2020 Small molecule-based targeting of chromatin regulatory factors has emerged as a promising therapeutic strategy in recent years. The development and ongoing clinical evaluation of novel agents targeting a range of chromatin regulatory processes, including
Gabriel J Sandoval +2 more
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A Role for Chromatin Remodeling in Cohesin Loading onto Chromosomes
Molecular Cell, 2019 Summary Cohesin is a conserved, ring-shaped protein complex that topologically embraces DNA. Its central role in genome organization includes functions in sister chromatid cohesion, DNA repair, and transcriptional regulation.
Sofia Munoz +2 more
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Chromatin Remodeling, DNA Double-Strand Break Repair, and Human Disease: How a Breakup Changes You [PDF]
BiomoleculesChromatin architecture is a central determinant of genomic stability. Effective DNA repair requires dynamic chromatin remodeling to grant repair factors timely access to lesions and to orchestrate repair pathway choice. Disruption of chromatin-regulatory
Adriana Chiaramida +2 more
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Chromatin-remodeling links metabolic signaling to gene expression
Molecular Metabolism, 2020 Background: ATP-dependent chromatin remodelers are evolutionarily conserved complexes that alter nucleosome positioning to influence many DNA-templated processes, such as replication, repair, and transcription.
Ashby J. Morrison
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Definitions, 2020 Chromatin Remodeling involves alterations of the content or activity of DNA-binding and chromatin-associated proteins that affect the function and higher order conformational state of chromatin, as well as the activity of specific genes or functional DNA
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Chromatin Remodeling in VSMC Phenotype Switching During Vascular Remodeling: From Mechanism to Therapeutic Potential [PDF]
BiomoleculesVascular remodeling is a characteristic pathological feature of various vascular diseases, including atherosclerosis, restenosis following vascular injury, hypertension, and aneurysms. The phenotypic switching of vascular smooth muscle cells (VSMCs) acts
Xiaozhu Ma +5 more
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Dietary polyphenols and chromatin remodeling
Critical Reviews in Food Science and Nutrition, 2017 Polyphenols are the most abundant phytochemicals in fruits, vegetables, and plant-derived beverages. Recent findings suggest that polyphenols display the ability to reverse adverse epigenetic regulation involved in pathological conditions, such as obesity, metabolic disorder, cardiovascular and neurodegenerative diseases, and various forms of cancer ...
Gian Luigi Russo +5 more
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