Results 11 to 20 of about 124,418 (260)
Chromatin remodeling in oligodendrogenesis
Вавиловский журнал генетики и селекции, 2021 Oligodendrocytes are one type of glial cells responsible for myelination and providing trophic support for axons in the central nervous system of vertebrates.
E. V. Antontseva, N. P. Bondar
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Chromatin Remodeling, DNA Double-Strand Break Repair, and Human Disease: How a Breakup Changes You [PDF]
BiomoleculesChromatin architecture is a central determinant of genomic stability. Effective DNA repair requires dynamic chromatin remodeling to grant repair factors timely access to lesions and to orchestrate repair pathway choice. Disruption of chromatin-regulatory
Adriana Chiaramida +2 more
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Chromatin Remodeling in VSMC Phenotype Switching During Vascular Remodeling: From Mechanism to Therapeutic Potential [PDF]
BiomoleculesVascular remodeling is a characteristic pathological feature of various vascular diseases, including atherosclerosis, restenosis following vascular injury, hypertension, and aneurysms. The phenotypic switching of vascular smooth muscle cells (VSMCs) acts
Xiaozhu Ma +5 more
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Chromatin remodeling complexes: architects influencing breast cancer progression [PDF]
Frontiers in Cell and Developmental BiologyAs one of the most common types of cancer, breast cancer strongly contributes to the increase in morbidity and mortality worldwide. Alterations in the genetic and epigenetic landscape contribute to the complexity and heterogeneity of the disease, making ...
Octavianus Giovani +3 more
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Chromatin remodelers in oligodendroglia [PDF]
Glia, 2020 AbstractOligodendrocytes, the myelinating cells in the vertebrate central nervous system, produce myelin sheaths to enable saltatory propagation of action potentials. The process of oligodendrocyte myelination entails a stepwise progression from precursor specification to differentiation, which is coordinated by a series of transcriptional and ...
Carlos Parras +3 more
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Frontiers in Cellular and Infection Microbiology, 2022 Intracellular pathogens manipulate the host cell for their own survival by contributing to modifications of host epigenome, and thus, altering expression of genes involved in the pathogenesis.
Harsimran Kaur Brar +5 more
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PTEN in Chromatin Remodeling [PDF]
Cold Spring Harbor Perspectives in Medicine, 2019 The tumor suppressor phosphatase and tension homolog (PTEN) is frequently mutated in human cancers, and it functions in multiple ways to safeguard cells from tumorigenesis. In the cytoplasm, PTEN antagonizes the PI3K/AKT pathway and suppresses cellular proliferation and survival.
Jingyi, Yang, Yuxin, Yin
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Biomedicines, 2023 Cardiovascular diseases are a major cause of death globally, with no cure to date. Many interventions have been studied and suggested, of which epigenetics and chromatin remodeling have been the most promising.
Lindsay Kraus, Brianna Beavens
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The chromatin remodeler SPLAYED regulates specific stress signaling pathways. [PDF]
PLoS Pathogens, 2008 Organisms are continuously exposed to a myriad of environmental stresses. Central to an organism's survival is the ability to mount a robust transcriptional response to the imposed stress. An emerging mechanism of transcriptional control involves dynamic
Justin W Walley +6 more
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Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration
Cell & Bioscience, 2023 The dynamic changes in chromatin conformation alter the organization and structure of the genome and further regulate gene transcription. Basically, the chromatin structure is controlled by reversible, enzyme-catalyzed covalent modifications to chromatin
Dongfang Jiang +4 more
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