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Biophysics of Chromatin Remodeling
Annual Review of Biophysics, 2021 As primary carriers of epigenetic information and gatekeepers of genomic DNA, nucleosomes are essential for proper growth and development of all eukaryotic cells. Although they are intrinsically dynamic, nucleosomes are actively reorganized by ATP-dependent chromatin remodelers.
Ilana M, Nodelman, Gregory D, Bowman
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Sodium Valproate-Induced Chromatin Remodeling
Frontiers in Cell and Developmental Biology, 2021 Valproic acid/sodium valproate (VPA), a drug originally prescribed as an anticonvulsant, has been widely reported to act on epigenetic marks by inducing histone acetylation, affecting the DNA and histone methylation status, and altering the expression of
Maria Luiza S. Mello
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Mechanism of chromatin remodeling [PDF]
Proceedings of the National Academy of Sciences, 2010 Results from biochemical and structural studies of the RSC chromatin-remodeling complex prompt a proposal for the remodeling mechanism: RSC binding to the nucleosome releases the DNA from the histone surface and initiates DNA translocation (through one or a small number of DNA base pairs); ATP binding completes translocation, and ATP hydrolysis resets ...
Yahli, Lorch +2 more
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Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster
Cells, 2023 ATP-dependent chromatin remodeling complexes are involved in nucleosome sliding and eviction and/or the incorporation of histone variants into chromatin to facilitate several cellular and biological processes, including DNA transcription, replication and
Yuri Prozzillo +5 more
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Chromatin Remodeling and Cancer [PDF]
Cancer Biology & Therapy, 2003 The fate of the cell relies on a delicate balance between gene expression and repression. The transcriptional control of the genome is maintained not only by transcription factors but also chromatin remodeling proteins. The purpose of the chromatin remodeling proteins is to alter the nucleosome architecture such that genes are exposed to or hidden from
Penny K, Davis, Rainer K, Brackmann
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The Latest Twists in Chromatin Remodeling [PDF]
Biophysical Journal, 2018 In its most restrictive interpretation, the notion of chromatin remodeling refers to the action of chromatin-remodeling enzymes on nucleosomes with the aim of displacing and removing them from the chromatin fiber (the effective polymer formed by a DNA molecule and proteins).
Blossey, R., Schiessel, H.
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Biology, 2020 Myogenesis is the biological process by which skeletal muscle tissue forms. Regulation of myogenesis involves a variety of conventional, epigenetic, and epigenomic mechanisms that control chromatin remodeling, DNA methylation, histone modification, and ...
Teresita Padilla-Benavides +2 more
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Theory of active chromatin remodeling [PDF]
Physical Review Letters, 2019 Nucleosome positioning controls the accessible regions of chromatin and plays essential roles in DNA-templated processes. ATP driven remodeling enzymes are known to be crucial for its establishment in vivo , but their non-equilibrium nature has hindered the development of a unified theoretical ...
Jiang, Zhongling, Zhang, Bin
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ATP-dependent chromatin assembly is functionally distinct from chromatin remodeling
eLife, 2013 Chromatin assembly involves the combined action of ATP-dependent motor proteins and histone chaperones. Because motor proteins in chromatin assembly also function as chromatin remodeling factors, we investigated the relationship between ATP-driven ...
Sharon E Torigoe +4 more
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Cancer Medicine, 2023 Genetic information encoded by DNA is packaged in the nucleus using the chromatin structure. The accessibility of transcriptional elements in DNA is controlled by the dynamic structural changes of chromatin for the appropriate regulation of gene ...
Yasumichi Kuwahara +3 more
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