Results 41 to 50 of about 4,645,161 (307)

Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation [PDF]

, 2013
Type II DNA topoisomerases catalyse DNA double-strand cleavage, passage and re-ligation to effect topological changes. There is considerable interest in elucidating topoisomerase II roles, particularly as these proteins are targets for anti-cancer drugs.
Porter, Andrew C. G., Panov, Konstantin I; id_orcid, Zomerdijk, Joost C.B.M., Russell, J., Miller, G. (Gail), Zomerdijk, Joost C B M, Porter, A.C., Porter, Andrew C G, Volkov, A., Panov, K.I., Panov, Konstantin I., Russell, J. (Jackie), Panova, T., Zomerdijk, J.C., Miller, Gail, Porter, Andrew C.G., Miller, G., Panova, Tatiana, Russell, Jackie, Ray, S., Ray, Swagat, Volkov, Arsen, Zomerdijk, Joost C. B. M.   +22 more
core   +1 more source

Structural insights into the Nipah virus nucleocapsid assembly

Communications Biology
Nipah virus (NiV), a lethal zoonotic henipavirus, poses a major public health threat. Its nucleoprotein (N) safeguards the genome by forming a nucleocapsid, which, together with the RNA-dependent RNA polymerase (L) and phosphoprotein (P), constitutes the
Ge Yang, Dmytro Kompaniiets, Dong Wang, Bin Liu   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519

Nature Communications
ERDRP-0519 is a potent nonnucleoside inhibitor active against measles virus (MeV) and other Morbilliviruses. Here we report cryo-EM structures of the compound bound to MeV polymerase complexes at 2.73 Å and 2.48 Å resolution, revealing a unique binding ...
Dong Wang, Fan Bu, Ge Yang, Bin Liu
doaj   +1 more source

Overexpression of AHL proteins enhances root hair production by altering the transcription of RHD6‐downstream genes

Plant Direct, 2023
AT‐HOOK MOTIF NUCLEAR LOCALIZED (AHL) proteins occur in all sequenced plant species. They bind to the AT‐rich DNA sequences in chromosomes and regulate gene transcription related to diverse biological processes.
Qike Zeng, Li Song, Mingzhe Xia, Zai Zheng, Ziang Chen, Ximing Che, Dong Liu   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Transcriptional Pulsing of a Developmental Gene [PDF]

Current Biology, 2006
It has not been possible to view the transcriptional activity of a single gene within a living eukaryotic cell. It is therefore unclear how long and how frequently a gene is actively transcribed, how this is modulated during differentiation, and how transcriptional events are dynamically coordinated in cell populations.
Chubb, Jonathan R., Trcek, Tatjana, Shenoy, Shailesh M., Singer, Robert H.   +3 more
openaire   +3 more sources

Mutational analysis of the gene start sequences of pneumonia virus of mice [PDF]

, 2007
The transcriptional start sequence of pneumonia virus of mice is more variable than that of the other pneumoviruses, with five different nine-base gene start (GS) sequences found in the PVM genome.
Easton, A. J. (Andrew J.), Dibben, Oliver   +1 more
core   +1 more source

Gene regulation during stress response transcription in Saccharomyces Cerevisiae [PDF]

, 2013
DYNAMIC TRANSCRIPTOME ANALYSIS MEASURES RATES OF MRNA SYNTHESIS AND DECAY IN YEAST To obtain rates of mRNA synthesis and decay in yeast, we established dynamic transcriptome analysis (DTA).
Miller, Christian
core   +1 more source

Structure of the measles virus ternary polymerase complex

Nature Communications
Measles virus (MeV) is a highly contagious pathogen that causes significant morbidity worldwide. Its polymerase machinery, composed of the large protein (L) and phosphoprotein (P), is crucial for viral replication and transcription, making it a promising
Dong Wang, Ge Yang, Bin Liu
doaj   +1 more source