Results 51 to 60 of about 4,645,161 (307)
Journal of Lipid Research, 2008 We tested whether sterol-regulatory element binding proteins (SREBPs) mediate sterol-regulated transactivation of the Niemann-Pick C-1 (NPC-1) gene. Loading granulosa cells with 22- or 25-hydroxycholesterol decreased NPC-1 mRNA, whereas culturing in ...
Nicolas Gévry +3 more
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Gene Transcript Profiling in Desert Bighorn Sheep
Wildlife Society Bulletin, 2020 Respiratory disease is a key factor affecting the conservation and recovery of bighorn sheep (Ovis canadensis) populations. Innovative, minimally invasive tools such as gene transcription–based diagnostics have the potential to improve our understanding ...
Lizabeth Bowen +7 more
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Frontiers in Microbiology, 2020 The objective of our study was to test whether limited microbial degradation at low pesticide concentrations could explain the discrepancy between overall degradability demonstrated in laboratory tests and their actual persistence in the environment ...
Johannes Wirsching +8 more
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Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility
Frontiers in Immunology, 2023 Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public health significance, with evidence of DM having about a three-fold risk for TB disease. TB
Phillip Ssekamatte +3 more
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Structure of the Nipah virus polymerase phosphoprotein complex
Nature CommunicationsThe Nipah virus (NiV), a member of the Paramyxoviridae family, is notorious for its high fatality rate in humans. The RNA polymerase machinery of NiV, comprising the large protein L and the phosphoprotein P, is essential for viral replication. This study
Ge Yang, Dong Wang, Bin Liu
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Bacterial MerR family transcription regulators: activationby distortion
Acta Biochimica et Biophysica Sinica, 2021 Transcription factors (TFs) modulate gene expression by regulating the accessibility of promoter DNA to RNA polymerases (RNAPs) in bacteria. The MerR family TFs are a large class of bacterial proteins unique in their physiological functions and molecular
Fang Chengli, Zhang Yu
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The “Fourth Dimension” of Gene Transcription [PDF]
Molecular Endocrinology, 2009 The three dimensions of space provide our relationship to position on the earth, but the fourth dimension of time has an equally profound influence on our lives. Everything from light and sound to weather and biology operate on the principle of measurable temporal periodicity.
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Remote control of gene transcription [PDF]
Human Molecular Genetics, 2005 In this review, we look at the most recent studies of DNA elements that function over long genomic distances to regulate gene transcription and will discuss the mechanisms genes employ to overcome the positive and negative influences of their genomic neighbourhood in order to achieve accurate programmes of expression.
Adam G, West, Peter, Fraser
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