Results 21 to 30 of about 1,686,914 (266)

Concordant and Heterogeneity of Single-Cell Transcriptome in Cardiac Development of Human and Mouse

Frontiers in Genetics, 2022
Normal heart development is vital for maintaining its function, and the development process is involved in complex interactions between different cell lineages. How mammalian hearts develop differently is still not fully understood.
Mengyue Shang, Mengyue Shang, Mengyue Shang, Yi Hu, Yi Hu, Yi Hu, Huaming Cao, Qin Lin, Qin Lin, Qin Lin, Na Yi, Na Yi, Na Yi, Junfang Zhang, Yanqiong Gu, Yujie Yang, Siyu He, Siyu He, Siyu He, Min Lu, Luying Peng, Luying Peng, Luying Peng, Luying Peng, Luying Peng, Li Li, Li Li, Li Li, Li Li, Li Li   +29 more
doaj   +1 more source

Transcriptional gene silencing in humans [PDF]

Nucleic Acids Research, 2016
It has been over a decade since the first observation that small non-coding RNAs can functionally modulate epigenetic states in human cells to achieve functional transcriptional gene silencing (TGS). TGS is mechanistically distinct from the RNA interference (RNAi) gene-silencing pathway.
Weinberg, Marc S, Morris, Kevin V
openaire   +3 more sources

Photosynthetic Acclimation to Fluctuating Irradiance in Plants

Frontiers in Plant Science, 2020
Unlike the short-term responses of photosynthesis to fluctuating irradiance, the long-term response (i.e., acclimation) at the chloroplast, leaf, and plant level has received less attention so far.
Alejandro Morales, Alejandro Morales, Alejandro Morales, Elias Kaiser   +3 more
doaj   +1 more source

Hypoxia-Inducible Factor-1α (HIF-1α) Potentiates β-Cell Survival after Islet Transplantation of Human and Mouse Islets

Cell Transplantation, 2013
A high proportion of β-cells die within days of islet transplantation. Reports suggest that induction of hypoxia-inducible factor-1α (HIF-1α) predicts adverse transplant outcomes.
Rebecca A. Stokes, Kim Cheng, Natasha Deters, Sue Mei Lau, Wayne J. Hawthorne, Philip J. O'connell, Jessica Stolp, Shane Grey, Thomas Loudovaris, Thomas W. Kay, Helen E. Thomas, Frank J. Gonzalez, Jenny E. Gunton   +12 more
doaj   +1 more source

Architecture and RNA binding of the human negative elongation factor

eLife, 2016
Transcription regulation in metazoans often involves promoter-proximal pausing of RNA polymerase (Pol) II, which requires the 4-subunit negative elongation factor (NELF).
Seychelle M Vos, David Pöllmann, Livia Caizzi, Katharina B Hofmann, Pascaline Rombaut, Tomasz Zimniak, Franz Herzog, Patrick Cramer   +7 more
doaj   +1 more source

Consumption of minas frescal cheese may be a source of human infection by Campylobacter jejuni

Bioscience Journal, 2020
Campylobacter spp. is an emerging pathogen that causes gastroenteritis in humans and the consumption of dairy food can characterize sources of infection.
Guilherme Paz Monteiro, Roberta Torres de Melo, Eliane Pereira Mendonça, Priscila Christen Nalevaiko, Mariela Moura Carreon, Ana Beatriz Garcez Buiatte, Fernanda Aparecida Longato Santos, Carla Ribeiro Pacheco, Yara Cristina Paiva Maia, Daise Aparecida Rossi   +9 more
doaj   +1 more source

The Functions of BET Proteins in Gene Transcription of Biology and Diseases

Frontiers in Molecular Biosciences, 2021
The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional regulators in biology.
Ka Lung Cheung, Claudia Kim, Ming-Ming Zhou   +2 more
doaj   +1 more source

Assessment of Combination Therapy in BALB/c Mice Injected With Carbapenem-Resistant Enterobacteriaceae Strains

Frontiers in Microbiology, 2015
Monotherapeutic options for carbapenem resistant infections are limited. Studies suggest that combination therapy may be associated with better outcomes than monotherapies. However, this is still controversial.
Noor eSalloum, Kohar Annie Kissoyan, Katia eCheaito, George F Araj, Rima eHanna Wakim, Souha S Kanj, Zeina Adnan Kanafani, Ghassan eDbaibo, GHASSAN M MATAR   +8 more
doaj   +1 more source

CDK9 as a Valuable Target in Cancer: From Natural Compounds Inhibitors to Current Treatment in Pediatric Soft Tissue Sarcomas

Frontiers in Pharmacology, 2020
Cyclin-Dependent Kinases (CDKs) are well-known reliable targets for cancer treatment being often deregulated. Among them, since the transcription-associated CDK9 represents the sentry of cell transcriptional homeostasis, it can be a valuable target for ...
Matteo Cassandri, Rossella Fioravanti, Silvia Pomella, Sergio Valente, Dante Rotili, Giada Del Baldo, Biagio De Angelis, Rossella Rota, Antonello Mai   +8 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source