Results 11 to 20 of about 1,686,914 (266)

Transcription of the T4 late genes [PDF]

open access: yesVirology Journal, 2010
This article reviews the current state of understanding of the regulated transcription of the bacteriophage T4 late genes, with a focus on the underlying biochemical mechanisms, which turn out to be unique to the T4-related family of phages or significantly different from other bacterial systems.
Geiduschek, E Peter   +1 more
openaire   +5 more sources

PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α

open access: yesCells, 2021
Background: PXR is a xenobiotic-responsive nuclear receptor that controls the expression of drug-metabolizing enzymes. Drug-induced activation of PXR sometimes causes drug–drug interactions due to the induced metabolism of co-administered drugs.
Ryota Shizu   +6 more
doaj   +1 more source

Differential Sensitivity of the Protein Translation Initiation Machinery and mTOR Signaling to MECP2 Gain- and Loss-of-Function Involves MeCP2 Isoform-Specific Homeostasis in the Brain

open access: yesCells, 2022
Eukaryotic gene expression is controlled at multiple levels, including gene transcription and protein translation initiation. One molecule with key roles in both regulatory mechanisms is methyl CpG binding protein 2 (MeCP2).
Marjorie Buist   +6 more
doaj   +1 more source

The Nuclear Lamina as an Organizer of Chromosome Architecture

open access: yesCells, 2019
The nuclear lamina (NL) is a meshwork of lamins and lamin-associated proteins adjoining the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses background transcription, whereas, in differentiated cell types, its ...
Yuri Y. Shevelyov, Sergey V. Ulianov
doaj   +1 more source

Interplay Between Glucose Metabolism and Chromatin Modifications in Cancer

open access: yesFrontiers in Cell and Developmental Biology, 2021
Cancer cells reprogram glucose metabolism to meet their malignant proliferation needs and survival under a variety of stress conditions. The prominent metabolic reprogram is aerobic glycolysis, which can help cells accumulate precursors for biosynthesis ...
Rui Ma   +4 more
doaj   +1 more source

Regulation of gene transcription in the epididymis [PDF]

open access: yesReproduction, 2001
Abstract The epididymis exhibits region-specific as well as cell-specific patterns of gene expression within the epithelium. The spatial and temporal patterns of gene expression originate during development and are critical to the formation and maintenance of a fully functional epididymis.
C M, Rodríguez, J L, Kirby, B T, Hinton
openaire   +2 more sources

Androgen Receptor-Mediated Transcription in Prostate Cancer

open access: yesCells, 2022
Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate cancer (PCa) growth and differentiation. This process involves a complex interplay of coregulatory proteins, chromatin remodeling complexes, and other ...
Doğancan Özturan   +2 more
doaj   +1 more source

Stability of the PHF10 subunit of PBAF signature module is regulated by phosphorylation: role of β-TrCP

open access: yesScientific Reports, 2017
The PBAF chromatin-remodeling complexes are multi-protein machines, regulating expression of genes involved in proliferation and differentiation. PHF10 is a subunit of the PBAF essential for its association with chromatin. Mammalian PHF10 is expressed as
Victor V. Tatarskiy   +5 more
doaj   +1 more source

Mild Inactivation of RE-1 Silencing Transcription Factor (REST) Reduces Susceptibility to Kainic Acid-Induced Seizures

open access: yesFrontiers in Cellular Neuroscience, 2020
RE-1 Silencing Transcription factor (REST) controls several steps in neural development by modulating the expression of a wide range of neural genes. Alterations in REST expression have been associated with the onset of epilepsy; however, whether such ...
Emanuele Carminati   +9 more
doaj   +1 more source

Inhibitory Effect of Thymoquinone on Listeria monocytogenes ATCC 19115 Biofilm Formation and Virulence Attributes Critical for Human Infection

open access: yesFrontiers in Cellular and Infection Microbiology, 2019
This study aimed to determine the antimicrobial activity of thymoquinone (TQ) against Listeria monocytogenes, and to examine its inhibitory effects on biofilm formation, motility, hemolysin production, and attachment-invasion of host cells.
Xin Miao   +7 more
doaj   +1 more source

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