Results 21 to 30 of about 405,975 (264)
Emerging role of mRNA epitranscriptomic regulation in chemoresistant cancer cells
Molecular & Cellular Oncology, 2020 Cancer persister cells remain a significant barrier to effective anti-cancer therapy. We found that melanoma persister cells undergo a reversible reprogramming of mRNA translation.
Shensi Shen, Xiaoxiao Sun
doaj +1 more source
Вавиловский журнал генетики и селекции, 2021 The expression of eukaryotic genes can be regulated at several stages, including the translation of mRNA. It is known that the structure of mRNA can affect both the efficiency of interaction with the translation apparatus in general and the choice of ...
D. A. Afonnikov +4 more
doaj +1 more source
Akt and mRNA translation by interferons [PDF]
Cell Cycle, 2008 The important antiviral and antitumor properties of interferons (IFNs) in vitro and in vivo have triggered extensive investigations over the years to understand the signals that control such responses in normal and malignant cells. The discovery of IFN-regulated Jak-Stat pathways and various ancillary cascades has led to the definition and ...
Surinder, Kaur +2 more
openaire +2 more sources
Regulation of gene expression in trypanosomatids: living with polycistronic transcription [PDF]
Open Biology, 2019 In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are excised by trans-splicing and polyadenylation. The lack of individual gene transcription control is compensated by control of mRNA processing, translation and ...
Christine Clayton
doaj +1 more source
Mechanism of Cytoplasmic mRNA Translation [PDF]
The Arabidopsis Book, 2015 Protein synthesis is a fundamental process in gene expression that depends upon the abundance and accessibility of the mRNA transcript as well as the activity of many protein and RNA-protein complexes. Here we focus on the intricate mechanics of mRNA translation in the cytoplasm of higher plants.
Karen S, Browning, Julia, Bailey-Serres
openaire +2 more sources
The long non-coding RNA GAS5 cooperates with the eukaryotic translation initiation factor 4E to regulate c-Myc translation. [PDF]
PLoS ONE, 2014 Long noncoding RNAs (lncRNAs) are important regulators of transcription; however, their involvement in protein translation is not well known. Here we explored whether the lncRNA GAS5 is associated with translation initiation machinery and regulates ...
Guangzhen Hu, Zhenkun Lou, Mamta Gupta
doaj +1 more source
Secondary Structure across the Bacterial Transcriptome Reveals Versatile Roles in mRNA Regulation and Function. [PDF]
PLoS Genetics, 2015 Messenger RNA acts as an informational molecule between DNA and translating ribosomes. Emerging evidence places mRNA in central cellular processes beyond its major function as informational entity.
Cristian Del Campo +3 more
doaj +1 more source
Regulation of mRNA Translation Is a Novel Mechanism for Phthalate Toxicity. [PDF]
PLoS ONE, 2016 Phthalates are a group of plasticizers that are widely used in many consumer products and medical devices, thus generating a huge burden to human health. Phthalates have been known to cause a number of developmental and reproductive disorders functioning
Jun Ling +4 more
doaj +1 more source
Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus
Cell Reports, 2016 Protein concentrations evolve under greater evolutionary constraint than mRNA levels. Translation efficiency of mRNA represents the chief determinant of basal protein concentrations.
J.J. David Ho +12 more
doaj +1 more source
Regulating mRNA translation with a kiss [PDF]
Nucleic Acids Symposium Series, 2008 Loop-loop interactions mediate the recognition between RNA hairpins leading to the formation of so-called kissing complexes. Both the size and the sequence of the loop are critical for ensuring stable interaction. Using in vitro selection we have characterized a few loop sequences that lead to the formation of highly stable kissing complexes.
Eric, Dausse +3 more
openaire +2 more sources