The role of TNRC6 proteins in gene silencing [PDF]
, 2013 Proteins of the GW182 family have recently emerged as key players in miRNAmediated gene silencing. They have been shown to interact with Argonaute proteins, components of the RISC and are assumed to mediate the repression in metazoa. Three paralogues are
Zipprich, Jakob Theophil
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A cytoplasmic complex mediates specific mRNA recognition and localization in yeast [PDF]
, 2011 In eukaryotes, hundreds of mRNAs are localized by specialized transport complexes. For localization, transcripts are recognized by RNA-binding proteins and incorporated into motor-containing messenger ribonucleoprotein particles (mRNPs).
Henning Urlaub +41 more
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Wobble uridine tRNA modification: a new vulnerability of refractory melanoma
Molecular & Cellular Oncology, 2018 The enzymes catalysing the modification of the wobble uridine (U34) of tRNAs (U34-enzymes) play an important role in tumor development. We have recently demonstrated that the U34-enzymes are crucial in the survival of glycolytic melanoma cultures through
Francesca Rapino, Pierre Close
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Xp54 and related (DDX6-like) RNA helicases : roles in messenger RNP assembly, translation regulation and RNA degradation [PDF]
, 2006 The DEAD-box RNA helicase Xp54 is an integral component of the messenger ribonucleoprotein (mRNP) particles of Xenopus oocytes. In oocytes, several abundant proteins bind pre-mRNA transcripts to modulate nuclear export, RNA stability and translational ...
Weston, A, Sommerville, John
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Translation Initiation Factors eIF3 and HCR1 Control Translation Termination and Stop Codon Read-Through in Yeast Cells [PDF]
, 2013 Translation is divided into initiation, elongation, termination and ribosome recycling. Earlier work implicated several eukaryotic initiation factors (eIFs) in ribosomal recycling in vitro.
Lucie Cuchalová +20 more
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The Role of Regulated mRNA Stability in Establishing Bicoid Morphogen Gradient in Drosophila Embryonic Development [PDF]
, 2011 The Bicoid morphogen is amongst the earliest triggers of differential spatial pattern of gene expression and subsequent cell fate determination in the embryonic development of Drosophila.
Niranjan Mahesan +5 more
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eLife, 2018 The cytoplasmic abundance of mRNAs is strictly controlled through a balance of production and degradation. Whereas the control of mRNA synthesis through transcription has been well characterized, less is known about the regulation of mRNA turnover, and a
Leon Y Chan +4 more
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Genetic influences on translation in yeast. [PDF]
PLoS Genetics, 2014 Heritable differences in gene expression between individuals are an important source of phenotypic variation. The question of how closely the effects of genetic variation on protein levels mirror those on mRNA levels remains open. Here, we addressed this
Frank W Albert +3 more
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Analysis of cis-acting expression determinants of the tobacco psbA 5’UTR in vivo [PDF]
, 2002 Chloroplast gene expression is predominantly regulated at the posttranscriptional levels of mRNA stability and translation efficiency. The expression of psbA, an important photosynthesis-related chloroplast gene, has been revealed to be regulated via its
Zou, Zhurong
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Operon mRNAs are organized into ORF-centric structures that predict translation efficiency
eLife, 2017 Bacterial mRNAs are organized into operons consisting of discrete open reading frames (ORFs) in a single polycistronic mRNA. Individual ORFs on the mRNA are differentially translated, with rates varying as much as 100-fold.
David H Burkhardt +5 more
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