Results 31 to 40 of about 405,975 (264)
Operon mRNAs are organized into ORF-centric structures that predict translation efficiency
eLife, 2017 Bacterial mRNAs are organized into operons consisting of discrete open reading frames (ORFs) in a single polycistronic mRNA. Individual ORFs on the mRNA are differentially translated, with rates varying as much as 100-fold.
David H Burkhardt +5 more
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Geneticin reduces mRNA stability.
PLoS ONE, 2022 Messenger RNA (mRNA) translation can lead to higher rates of mRNA decay, suggesting the ribosome plays a role in mRNA destruction. Furthermore, mRNA features, such as codon identities, which are directly probed by the ribosome, correlate with mRNA decay ...
Yavuz T Durmaz +2 more
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eLife, 2018 The cytoplasmic abundance of mRNAs is strictly controlled through a balance of production and degradation. Whereas the control of mRNA synthesis through transcription has been well characterized, less is known about the regulation of mRNA turnover, and a
Leon Y Chan +4 more
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Wobble uridine tRNA modification: a new vulnerability of refractory melanoma
Molecular & Cellular Oncology, 2018 The enzymes catalysing the modification of the wobble uridine (U34) of tRNAs (U34-enzymes) play an important role in tumor development. We have recently demonstrated that the U34-enzymes are crucial in the survival of glycolytic melanoma cultures through
Francesca Rapino, Pierre Close
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Translation and mRNA Stability Control
Annual Review of Biochemistry, 2023 Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the post-transcriptional process that profoundly impact protein production in a cell. While it is widely known that ribosomes produce proteins, studies during the past decade have surprisingly revealed that ribosomes also control mRNA stability in a codon-dependent ...
Qiushuang, Wu, Ariel A, Bazzini
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Regulation of mRNA translation by a photoriboswitch [PDF]
eLife, 2019 Optogenetic tools have revolutionized the study of receptor-mediated processes, but such tools are lacking for RNA-controlled systems. In particular, light-activated regulatory RNAs are needed for spatiotemporal control of gene expression. To fill this gap, we used in vitro selection to isolate a novel riboswitch that selectively binds the trans ...
Kelly A Rotstan +7 more
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Genetic influences on translation in yeast. [PDF]
PLoS Genetics, 2014 Heritable differences in gene expression between individuals are an important source of phenotypic variation. The question of how closely the effects of genetic variation on protein levels mirror those on mRNA levels remains open. Here, we addressed this
Frank W Albert +3 more
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Folate regulates RNA m5C modification and translation in neural stem cells
BMC Biology, 2022 Background Folate is an essential B-group vitamin and a key methyl donor with important biological functions including DNA methylation regulation. Normal neurodevelopment and physiology are sensitive to the cellular folate levels.
Xiguang Xu +5 more
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Zdorovʹe Rebenka, 2022 The scientific review considers the mechanisms of action of cytoplasmic microRNAs, namely miRNA-mediated silencing, which is caused during the initiation and post-initiation period of translation.
A.E. Abaturov, V.L. Babуch
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The link between adjacent codon pairs and mRNA stability
BMC Genomics, 2017 Background Evidence in diverse organisms suggests that codon optimality is a major determinant of mRNA translation and degradation. Codon optimality is thought to act by modulating the efficiency of ribosome elongation.
Yuriko Harigaya, Roy Parker
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