Results 1 to 10 of about 2,084,278 (307)

An ensemble method to predict target genes and pathways in uveal melanoma

Open Life Sciences, 2018
This work proposes to predict target genes and pathways for uveal melanoma (UM) based on an ensemble method and pathway analyses. Methods: The ensemble method integrated a correlation method (Pearson correlation coefficient, PCC), a causal inference ...
Wei Chao, Wang Lei, Zhang Han
doaj   +1 more source

Ontogenic Profile of Gluconeogenic Key Enzyme Gene Expressions in Embryonic Chicken Liver and Muscle

The Journal of Poultry Science, 2013
To elucidate biochemical mechanisms underlining high plasma glucose in chicken embryo, gene expression profile of gluconeogenic key enzymes were characterized.
Tushar K. Roy, Atsushi Iwasawa, Yasutake Shimizu, Koji Kageyama, Norio Yoshizaki   +4 more
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SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC50 values were found to be
Raed Shalaby, Jacobus P. Petzer, Anél Petzer, Usman M. Ashraf, Ealla Atari, Fawaz Alasmari, Sivarajan Kumarasamy, Youssef Sari, Ashraf Khalil   +8 more
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Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”

4 open, 2019
It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Integrated Bioinformatics Analysis for the Identification of Key lncRNAs, mRNAs, and Potential Drugs in Clear Cell Renal Cell Carcinomas

International Journal of General Medicine, 2023
Sheng Liu,1,* Guanyun Shi,1 Zhengbo Pan,1 Weisong Cheng,1 Linfei Xu,1 Xingzhang Lin,1 Yongfeng Lin,1 Liming Zhang,1 Guanghua Ji,1 Xin Lv,1 Dongguo Wang2,* 1Department of Urinary Surgery, Taizhou Municipal Hospital Affiliated with Taizhou ...
Liu S, Shi G, Pan Z, Cheng W, Xu L, Lin X, Lin Y, Zhang L, Ji G, Lv X, Wang D   +10 more
doaj  

The Development of mRNA Vaccines for Infectious Diseases: Recent Updates

Infection and Drug Resistance, 2021
Nitika,1,2 Jiao Wei,1,2 Ai-Min Hui1,2 1Fosun Pharma USA Inc., Boston, MA, USA; 2Shanghai Fosun Pharmaceutical Industrial Development, Co., Ltd., Shanghai, People’s Republic of ChinaCorrespondence: Ai-Min HuiShanghai Fosun Pharmaceutical Industrial ...
Nitika, Wei J, Hui AM
doaj  

Potential Predictive Value of miR-125b-5p, miR-155-5p and Their Target Genes in the Course of COVID-19

Infection and Drug Resistance, 2022
Xuewen Li,1 Yiting Wang,1 Qi Zhou,2 Junqi Pan,3 Jiancheng Xu1 1Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, People’s Republic of China; 2Department of Pediatrics, First Hospital of Jilin University, Changchun, People ...
Li X, Wang Y, Zhou Q, Pan J, Xu J
doaj  

Association between FOXP3 polymorphisms and expression and neuromyelitis optica spectrum disorder risk in the Northern Chinese Han population

Translational Neuroscience
Forkhead box P3 (FOXP3) plays a critical role in the pathogenesis of autoimmune disorders. In the present study, we genotyped three single-nucleotide polymorphisms, namely, rs2232365, rs3761548, and rs3761549, to determine the relationship between FOXP3 ...
Liu Jing, Wang Gaoning, Yang Jiahe, Wang Yulin, Guo Ruoyi, Li Bin   +5 more
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Comprehensive Evaluation of Gastrointestinal Factors Influencing the Stability and Function of mRNA-Encapsulated Lipid Nanoparticles. [PDF]

Drug Dev Res
Shinkai T, Ogawa K, Mohamed MS, Ozeki T.
europepmc   +1 more source

Centriolar satellites regulate <i>CEP350</i> mRNA stability and centrosome amplification. [PDF]

Mol Biol Cell
Martinez A, Pearson CG.
europepmc   +1 more source