Results 11 to 20 of about 1,902,766 (313)

mRNA as a Therapeutics: Understanding mRNA Vaccines

Advanced Pharmaceutical Bulletin, 2021
Vaccination is one of the important approaches in the prevention and control of diseases. Although the capacity to present antigens other than the disease-specific antigen in the traditional vaccine composition provides a potential benefit by increasing its protective efficacy, many components that are not needed for the related disease are also ...
Ferdi Oguz, Harika Atmaca
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mRNA–mRNA duplexes that autoelicit Staufen1-mediated mRNA decay [PDF]

Nature Structural & Molecular Biology, 2013
We report a new mechanism by which human mRNAs cross-talk: an Alu element in the 3' untranslated region (3' UTR) of one mRNA can base-pair with a partially complementary Alu element in the 3' UTR of a different mRNA, thereby creating a Staufen1 (STAU1)-binding site (SBS). STAU1 binding to a 3'-UTR SBS was previously shown to trigger STAU1-mediated mRNA
Gong, Chenguang, Tang, Yalan, Maquat, Lynne E.   +2 more
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mRNA fate [PDF]

RNA Biology, 2013
The life of an mRNA molecule begins with transcription and ultimately ends in degradation. In the course of its life, however, mRNA is examined, modified in various ways and transported before eventually being translated into proteins. All these processes are performed by proteins and non-coding RNAs whose complex interplay in the cell contributes to ...
Denti, Michela Alessandra, Viero, Gabriella, Provenzani, Alessandro, Quattrone, Alessandro, Macchi, Paolo   +4 more
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mRNA Vaccine Platform: mRNA Production and Delivery

Russian Journal of Bioorganic Chemistry, 2023
Vaccination is the most efficient way to prevent infectious diseases. mRNA-based vaccines is a new approach to vaccine development, which have several very useful advantages over other types of vaccines. Since mRNA encodes only the target antigen there is no potential risk of infection as in the case with attenuated or inactivated pathogens.
Litvinova, V. R., Rudometov, A. P., Karpenko, L. I., Ilyichev, A. A.   +3 more
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Modeling the effect of rRNA-mRNA interactions and mRNA folding on mRNA translation in chloroplasts

Computational and Structural Biotechnology Journal, 2022
The process of translation initiation in prokaryotes is mediated by the hybridization of the 16S rRNA of the small ribosomal subunit with the mRNA in a short region called the ribosomal binding site. However, translation initiation in chloroplasts, which have evolved from an ancestral bacterium, is not well understood. Some studies suggest that in many
Stav Carmel Ezra, Tamir Tuller
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Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system [PDF]

, 2015
This work was supported by Medical Research Scotland (FRG353 to VAS), the FP7- Directorate-General for Research and Innovation of the European Commission (EU HEALTHF4-2012-305033 to Coordinating Action Systems Medicine to DJH); the Chief Scientist Office
Smith, V. Anne, Um, In Hwa, Harrison, David J, Langdon, Simon, Smith, V Anne, Koussounadis, Antonis, Harrison, David James, Langdon, Simon P.   +7 more
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Quantification of pre-mRNA escape rate and synergy in splicing [PDF]

, 2014
Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape the nucleus with a retained intron. Intron retention can control gene expression and increase proteome diversity.
Becskei, Attila, Bonde, M. (M) M. (M), Becskei, A. (A), Baudrimont, A. (A), Séraphin, B. (Bertrand), Mi Bonde, Marie, Voegeli, Sylvia, Bonde, Marie Mi, Baudrimont, Antoine, Voegeli, S. (S), Séraphin, Bertrand, Voegeli, S, Baudrimont, A, Becskei, A   +13 more
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Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex

, 2023
Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation.
Hall, Michael, Winkler, Gerlof Sebastiaan, Pavanello, Lorenzo   +2 more
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mRNA distribution in skeletal muscle is associated with mRNA size [PDF]

Journal of Cell Science, 2021
ABSTRACT Skeletal muscle myofibers are large and elongated cells with multiple and evenly distributed nuclei. Nuclear distribution suggests that each nucleus influences a specific compartment within the myofiber and implies a functional role for nuclear positioning. Compartmentalization of specific mRNAs and proteins has been reported at
Helena Pinheiro, Mafalda Ramos Pimentel, Catarina Sequeira, Luís Manuel Oliveira, Anna Pezzarossa, William Roman, Edgar R. Gomes   +6 more
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In vivo Imaging of oskar mRNA transport reveals the mechanism of posterior localization [PDF]

, 2008
oskar mRNA localization to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Although this localization requires microtubules and the plus end-directed motor, kinesin, its mechanism is controversial and ...
Zimyanin, Vitaly L, Gilchrist, Michael J., Pecreaux, J, Davis, Ilan, Zimyanin, Vitaly L., Gilchrist, Michael J, Clark, Alejandra, St Johnston, D, Belaya, K, Pecreaux, Jacques, Clark, A, Gilchrist, MJ, Davis, I, St Johnston, Daniel, Zimyanin, VL, Belaya, Katsiaryna, Johnston, Daniel St   +16 more
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