Results 31 to 40 of about 2,084,278 (307)

Folding transitions during assembly of the eukaryotic mRNA cap-binding complex. [PDF]

, 2006
The cap-binding protein eIF4E is the first in a chain of translation initiation factors that recruit 40S ribosomal subunits to the 5' end of eukaryotic mRNA. During cap-dependent translation, this protein binds to the 5'-terminal m(7)Gppp cap of the mRNA,
von der Haar, Tobias, Ptushkina, Marina, Wagner, Gerhard, McCarthy, John E G, Moerke, Nathan, Oku, Yuko, McCarthy, John E. G., Mccarthy, John, Gross, John D.   +8 more
core   +1 more source

Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes

Nature Communications, 2017
The BioID approaches takes advantage of the promiscuous biotinylation enzyme (BirA*) to identify proteins that closely interact. Here the authors improve the resolution of BioID using a protein fragment complementation approach that allows the assignment
Isabel Myriam Schopp, Cinthia Claudia Amaya Ramirez, Jerneja Debeljak, Elisa Kreibich, Merle Skribbe, Klemens Wild, Julien Béthune   +6 more
doaj   +1 more source

Microarray profile of B cells from Graves’ disease patients reveals biomarkers of proliferation

Endocrine Connections, 2020
B lymphocytes are the source of autoantibodies against the thyroid-stimulating hormone receptor (TSHR) in Graves’ disease (GD). Characterization of au toimmune B-cell expression profiles might enable a better understanding of GD pathogenesis.
Xuechao Jiang, Yonghui Wang, Xiaoying Li, Leqi He, Qian Yang, Wei Wang, Jun Liu, Bingbing Zha   +7 more
doaj   +1 more source

Integrative Analysis Of LncRNAs In Kidney Cancer To Discover A New LncRNA (LINC00847) As A Therapeutic Target For Staphylococcal Enterotoxin Tst Gene [PDF]

Cell Journal, 2020
Objective Bacterial toxin can cause cell death through induction of apoptosis in cancer cell lines as well as changes in the expression patterns of long non-coding RNAs (lncRNAs) and genes. In the present study, the effect of tst gene on ACHN cell lines
Maryam Safarpour-Dehkordi, Abbas Doosti, Mohammad-Saied Jami   +2 more
doaj   +1 more source

mRNA distribution in skeletal muscle is associated with mRNA size [PDF]

Journal of Cell Science, 2021
ABSTRACT Skeletal muscle myofibers are large and elongated cells with multiple and evenly distributed nuclei. Nuclear distribution suggests that each nucleus influences a specific compartment within the myofiber and implies a functional role for nuclear positioning. Compartmentalization of specific mRNAs and proteins has been reported at
Helena Pinheiro, Mafalda Ramos Pimentel, Catarina Sequeira, Luís Manuel Oliveira, Anna Pezzarossa, William Roman, Edgar R. Gomes   +6 more
openaire   +2 more sources

Investigation of the anti-influenza activity of siRNA complexes against the cellular genes FLT4, Nup98, and Nup205 in vitro

Тонкие химические технологии, 2022
Objectives. Evaluation of changes in the viral activity of influenza A/WSN/33 after complex knockdown of combinations of cellular genes FLT4, Nup98 and Nup205 in human lung cell culture A549. Methods.
E. A. Pashkov, M. O. Korotysheva, A. V. Pak, E. B. Faizuloev, A. V. Sidorov, A. V. Poddubikov, E. P. Bystritskaya, Yu. E. Dronina, V. K. Solntseva, T. A. Zaiceva, E. P. Pashkov, A. S. Bykov, O. A. Svitich, V. V. Zverev   +13 more
doaj   +1 more source

Association of clinical and epidemiological characteristics with COVID-19 BNT162b2 mRNA vaccine short-term adverse reactions in healthcare workers

Human Vaccines & Immunotherapeutics, 2021
Introduction The aim of the study was to investigate the prevalence and severity of adverse reactions (ARs) after immunization of healthcare workers (HCWs) with BNT162b2 vaccine and to associate them with clinical and epidemiological characteristics ...
Filippos Filippatos, Elizabeth-Barbara Tatsi, Charilaos Dellis, Nick Dessypris, Vassiliki Syriopoulou, Athanasios Michos   +5 more
doaj   +1 more source

Not so cold! Improving the thermostability of mRNA vaccines

Expert Review of Vaccines
Introduction One of the biggest challenges in the mRNA-LNP vaccine field is product stabilization to overcome the logistical hurdles linked to the ultra-cold distribution chain associated with first-generation mRNA SARS-CoV-2 vaccines.
Jean Haensler, Luc Even, Pierre Wils, Fethi Bensaid, Anusha Dias, Hongfeng Deng, Shrirang Karve, Frank DeRosa   +7 more
doaj   +1 more source

Cancer-testis genes in colon cancer [PDF]

Терапевтический архив, 2017
The expression of cancer-testis (CT) genes varies with tumor type. There are tumors with high, low, and intermediate gene expressions. Tumor cells of different origin are characterized by ST gene co-expression.
N R Hilal, D V Novikov, V V Novikov, A V Karaulov   +3 more
doaj   +1 more source

Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines

npj Vaccines
Lipid nanoparticle (LNP) components can impact the safety and immunogenicity of mRNA vaccines. Here we examine the mechanisms contributing to the performance of mRNA-LNP vaccines by exploring the impact of nucleoside modifications and LNP components on ...
Hillary Danz, Allison Dauner, Shraddha Sharma, Mihaela Babiceanu, Nicholas Clark, Robert Jordan Ontiveros, Robert Amezquita, Alisa Zhilin-Roth, Eric Reyes, Catherine Khoo, Kara Gilbert, Janhavi Nadkarni, Omkar Chaudhary, Christina Lee, Ana Kume, Azadeh Bahadoran, Mona Motwani, Bin Lu, Wei Zong, Andrew Kettring, Alex Shumate, Shrirang Karve, Anusha Dias, Monica Wu, Xiaobo Gu, Yanhua Yan, Daniel G. Anderson, Brian Schanen, Sudha Chivukula, Frank DeRosa   +29 more
doaj   +1 more source