Results 31 to 40 of about 2,541,766 (304)

mRNA epitranscriptomics

RNA
Epitranscriptomics refers to chemical changes in RNAs and includes numerous chemical types with varying stoichiometry and functions. RNA modifications are highly diverse in chemistry and respond in cell-type- and cell-state-dependent manners that enable and facilitate the execution of a wide array of biological functions.
Meyer, Kate D., Pan, Tao
openaire   +2 more sources

The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids. [PDF]

, 2017
Trypanosomatid protozoa are unusual eukaryotes that are well known for having unusual ways of controlling their gene expression. The lack of a refined mode of transcriptional control in these organisms is compensated by several post-transcriptional ...
Campbell, David A, de Melo Neto, Osvaldo P, Freire, Eden R, Sturm, Nancy R   +3 more
core   +2 more sources

Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines

npj Vaccines
Lipid nanoparticle (LNP) components can impact the safety and immunogenicity of mRNA vaccines. Here we examine the mechanisms contributing to the performance of mRNA-LNP vaccines by exploring the impact of nucleoside modifications and LNP components on ...
Hillary Danz, Allison Dauner, Shraddha Sharma, Mihaela Babiceanu, Nicholas Clark, Robert Jordan Ontiveros, Robert Amezquita, Alisa Zhilin-Roth, Eric Reyes, Catherine Khoo, Kara Gilbert, Janhavi Nadkarni, Omkar Chaudhary, Christina Lee, Ana Kume, Azadeh Bahadoran, Mona Motwani, Bin Lu, Wei Zong, Andrew Kettring, Alex Shumate, Shrirang Karve, Anusha Dias, Monica Wu, Xiaobo Gu, Yanhua Yan, Daniel G. Anderson, Brian Schanen, Sudha Chivukula, Frank DeRosa   +29 more
doaj   +1 more source

Cancer-testis genes in colon cancer [PDF]

Терапевтический архив, 2017
The expression of cancer-testis (CT) genes varies with tumor type. There are tumors with high, low, and intermediate gene expressions. Tumor cells of different origin are characterized by ST gene co-expression.
N R Hilal, D V Novikov, V V Novikov, A V Karaulov   +3 more
doaj   +1 more source

A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs. [PDF]

, 2017
mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown
Ding, Junjun, Guo, Yibin, Huang, Chunliu, Huang, Shanshan, Huang, Weijun, Huang, Xi, Jia, Jie, Ming, Siqi, Shi, Junjie, Shi, Yongsheng, Wu, Xingui, Xiang, Andy Peng, Yao, Chengguo, Zhang, Rui, Zhao, Wei   +14 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Impact of Extended Dosing Intervals and Ipsilateral Versus Contralateral Boosting on mRNA Vaccine Immunogenicity in Mice

Vaccines
Background: Although mRNA vaccines have the potential to be developed and deployed rapidly to combat infectious diseases, the ideal method of administration and boosting schedule strategy for generating optimal immunogenicity is an area of active ...
Bin Lu, Omkar Chaudhary, Balaji Banoth, Janhavi Nadkarni, Wei Zong, Emilie Mausser, Hillary Danz, Mona Motwani, Sophie Ruiz, Donghui Zhang, Gopinath Nageshwaran, Bachra Rokbi, William Warren, Frank DeRosa, Sudha Chivukula   +14 more
doaj   +1 more source

Asynchronous Rhythm of Steroidogenic Factor 1 and Period Homolog 2 mRNA Expression in Mouse Y1 Adrenocorticol Tumor Cells [PDF]

, 2010
The relationship between the expression of Steroidogenic factor 1 (Sf1) and the circadian-related gene, period homolog 2 (Per2), in the adrenal cortex is still unknown.
Hajime Nawata, Kenji Ohe, Koichi Node, Koichi Oba, Kouichirou Sonoda, Makoto Akashi, Masatoshi Nomura, Ryoichi Takayanagi, Taijiro Okabe, Toshihiko Yanase   +9 more
core   +1 more source

Genome-wide profiling of uncapped mRNA [PDF]

, 2012
Gene transcripts are under extensive posttranscriptional regulation, including the regulation of their stability. A major route for mRNA degradation produces uncapped mRNAs, which can be generated by decapping enzymes, endonucleases, and small RNAs ...
BD Gregory, C Addo-Quaye, C Llave, JM Franco-Zorrilla, MA German, P Mitchell, R Parker, RA Gutierrez, X Liu, Y Jiao   +9 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source