Results 51 to 60 of about 1,902,766 (313)
Regulation of mRNA stability via BRF1 and other AU-binding proteins [PDF]
, 2005 Steady state levels of mRNAs are determined by the rate of synthesis and degradation. A well-known cis-element conferring instability to mRNA is the so-called AU-rich element (ARE), which is present in the 3’ untranslated region (3’UTR) of many cytokines,
Schmidlin-Stalder, Martin
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EXPRESSION OF AID-SPECIFIC mRNA IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA
Медицинская иммунология, 2015 The aim of this study was to evaluate a possible role of AID (AICDA – activation-induced (cytidine) deaminase) in the bronchial asthma (BA) pathogenesis. Materials and methods.
V. N. Mineev +2 more
doaj +1 more source
RNAEpitranscriptomics refers to chemical changes in RNAs and includes numerous chemical types with varying stoichiometry and functions. RNA modifications are highly diverse in chemistry and respond in cell-type- and cell-state-dependent manners that enable and facilitate the execution of a wide array of biological functions.
Meyer, Kate D., Pan, Tao
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The mRNA encoding the yeast ARE-binding protein Cth2 is generated by a novel 3 ' processing pathway
, 2008 Microarray analyses of mRNAs over-expressed in strains lacking the nuclear exosome component Rrp6 identified the transcript encoding the ARE-binding protein Cth2, which functions in cytoplasmic mRNA stability.
Bohnsack, Markus T. +2 more
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A workflow to define structural classes and classify nucleic acids circular dichroism spectra
QRB DiscoveryCircular dichroism (CD) spectroscopy is a widely utilized technique for studying the structures of chiral molecules, including nucleic acids. It is particularly valued for its ability to quickly probe structural changes in these biomolecules. Despite its
Kevin Mosca +5 more
doaj +1 more source
Genomic structure and expression of the porcine ACTC1 gene
Czech Journal of Animal Science, 2018 A partial cDNA (~1200 bp) of the porcine ACTC1 gene was identified in the subtracted foetal hind limb muscle cDNA library (44 days of gestation; using m. biceps femoris cDNA as the driver).
Antonín Stratil +9 more
doaj +1 more source
Insights into the mRNA Cleavage Mechanism by MazF, an mRNA Interferase [PDF]
Journal of Biological Chemistry, 2005 MazF is an Escherichia coli toxin that is highly conserved among the prokaryotes and plays an important role in growth regulation. When MazF is induced, protein synthesis is effectively inhibited. However, the mechanism of MazF action has been controversial.
Yonglong, Zhang +4 more
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Physico-chemical and biological investigation of new mRNA delivery systems
, 2023 reservedNegli ultimi anni l’utilizzo di terapie a base di mRNA stanno riscontrando sempre più successo. In particolare, la necessità di ricercare un vaccino contro il COVID 19 ha portato ad una rapida progressione della ricerca in tale settore.
FABRELLO, LORENZO
core