Results 71 to 80 of about 1,519,200 (263)
Атеросклероз, 2015 The article covers the relevance of studying mRNA expression profile of genes of innate immune receptors, in particular genes of TLRs. The ability of TLRs to express at the surface of various cells, even at those that do not belong to the innate and ...
V. A. Ipatova, A. V. Ponasenko
doaj
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
An ensemble method to predict target genes and pathways in uveal melanoma
Open Life Sciences, 2018 This work proposes to predict target genes and pathways for uveal melanoma (UM) based on an ensemble method and pathway analyses. Methods: The ensemble method integrated a correlation method (Pearson correlation coefficient, PCC), a causal inference ...
Wei Chao, Wang Lei, Zhang Han
doaj +1 more source
RNA cargo in motion: the exosomal connection to head and neck cancers [PDF]
ExRNAHead and neck cancers (HNCs) are malignant tumors that differ from carcinomas in their biological behaviour and require a different diagnostic and treatment approach, especially in cancers like lung, breast, and prostate.
Vasanth Kanth Thasma Loganathan +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Ontogenic Profile of Gluconeogenic Key Enzyme Gene Expressions in Embryonic Chicken Liver and Muscle
The Journal of Poultry Science, 2013 To elucidate biochemical mechanisms underlining high plasma glucose in chicken embryo, gene expression profile of gluconeogenic key enzymes were characterized.
Tushar K. Roy +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2023 mRNA (messenger RNA) is a large class of single-stranded RNA molecules, and a blueprint for protein synthesis, transferring the genetic information from the DNA to the ribosome, where they specify the amino acid sequence of the protein product. During the movement of the ribosome along the mRNA, the base sequence on the mRNA is read and each three-base
openaire +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source