Results 81 to 90 of about 2,084,278 (307)

Preferential Translation of mRNAs in an mRNA-Dependent Reticulocyte Lysate [PDF]

European Journal of Biochemistry, 1980
Messenger RNA competition experiments were performed in an mRNA-dependent reticulocyte lysate using three kinds of mRNA: rabbit globin mRNA, calf eye lens mRNA and RNA of turnip yellow mosaic virus. Our results indicate that at supersaturating concentrations of mRNA preferential translation of certain mRNA species can be observed.
F A, Asselbergs, E, Meulenberg, W J, van Venrooij, H, Bloemendal   +3 more
openaire   +2 more sources

Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. [PDF]

, 2010
Kaposi's sarcoma (KS) is the most common cancer among HIV-positive patients. Histogenetic origin of KS has long been elusive due to a mixed expression of both blood and lymphatic endothelial markers in KS tumor cells.
Kafka, Darren, Koh, Chester J., Aguilar Berenice, Yoo, Jaehyuk, Hong Young-Kwon, Hong, Young-Kwon, Lee, Sunju, Choi, Inho, Yoo Jaehyuk, Haas, Jürgen G., Kang Jinjoo, Lee Ha Neul, Swapnika Ramu, Kang, Jinjoo, Young-Kwon Hong, Juneyong Lee, Ramu, Swapnika, Darren Kafka, Lee, Juneyong, Kafka Darren, Lee Sunju, Choi Inho, Juergen Haas, Haas, Juergen, Lee Juneyong, Sunju Lee, Inho Choi, Ha Neul Lee, Haas Juergen, Aguilar, Berenice, Chester J. Koh, Jinjoo Kang, Chester J Koh, Jaehyuk Yoo, Koh Chester J., Berenice Aguilar, Ramu Swapnika, Lee, Ha Neul   +37 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Spatial transcriptomic mapping of early immune responses to an adjuvanted recombinant hemagglutinin vaccine

Frontiers in Immunology
Vaccination relies on innate and adaptive responses initiated at the injection site followed by activation in draining lymph nodes. However, high-plex, spatially resolved maps that couple injection site signals with transcriptomic programs in draining ...
Laurelle Jackson, Laurelle Jackson, Sarah M. Williams, Sarah M. Williams, James Sinclair, Ana Kume, Azadeh Bahadoran, Ingeborg M. Langohr, Hillary Danz, Bin Lu, Dinesh S. Bangari, Amanda J. Cox, Amanda J. Cox, Laurence Macia, Sudha Chivukula, Nicholas P. West, Nicholas P. West   +16 more
doaj   +1 more source

On the role of ras and BRF1 in the regulation of ARE-dependent mRNA-turnover [PDF]

, 2004
Stability of the mRNAs of cytokines, chemokines, growth-factors, protooncogenes and others are regulated via an AU-rich element (ARE) in their 3’ untranslated region (UTR).
Leuenberger, Sabrina Angélique
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Artificial intelligence-driven rational design of ionizable lipids for mRNA delivery

Nature Communications
Lipid nanoparticles (LNPs) have proven effective in mRNA delivery, as evidenced by COVID-19 vaccines. Its key ingredient, ionizable lipids, is traditionally optimized by inefficient and costly experimental screening.
Wei Wang, Kepan Chen, Ting Jiang, Yiyang Wu, Zheng Wu, Hang Ying, Hang Yu, Jing Lu, Jinzhong Lin, Defang Ouyang   +9 more
doaj   +1 more source

Insights into the mRNA Cleavage Mechanism by MazF, an mRNA Interferase [PDF]

Journal of Biological Chemistry, 2005
MazF is an Escherichia coli toxin that is highly conserved among the prokaryotes and plays an important role in growth regulation. When MazF is induced, protein synthesis is effectively inhibited. However, the mechanism of MazF action has been controversial.
Yonglong, Zhang, Junjie, Zhang, Hiroto, Hara, Ikunoshin, Kato, Masayori, Inouye   +4 more
openaire   +2 more sources

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

The Role of Regulated mRNA Stability in Establishing Bicoid Morphogen Gradient in Drosophila Embryonic Development [PDF]

, 2011
The Bicoid morphogen is amongst the earliest triggers of differential spatial pattern of gene expression and subsequent cell fate determination in the embryonic development of Drosophila.
Niranjan Mahesan, Liu Wei, Liu, Wei, Niranjan, Mahesan, Mahesan Niranjan, Wei Liu   +5 more
core   +3 more sources