Results 101 to 110 of about 2,541,766 (304)
Атеросклероз, 2015 The article covers the relevance of studying mRNA expression profile of genes of innate immune receptors, in particular genes of TLRs. The ability of TLRs to express at the surface of various cells, even at those that do not belong to the innate and ...
V. A. Ipatova, A. V. Ponasenko
doaj
Augmented Hypothalamic Corticotrophin-Releasing Hormone mRNA and Corticosterone Responses to Stress in Adult Rats Exposed to Perinatal Hypoxia [PDF]
, 2007 Stressful events before or just after parturition alter the subsequent phenotypical response to stress in a general process termed programming. Hypoxia during the period before and during parturition, and in the postnatal period, is one of the most ...
Cullinan, William E +2 more
core +2 more sources
Science, 2016 DNA Events DNA is packaged into chromatin, and it must be actively unpacked, or remodeled, for genes to be transcribed into mRNA. That mRNA, synthesized in the nucleus, is also packed onto proteins, forming mRNA ribonucleoparticles (mRNPs). mRNPs are then shunted into the cytoplasm. Babour et al.
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Ribosome Flow Model with Extended Objects
, 2017 We study a deterministic mechanistic model for the flow of ribosomes along the mRNA molecule, called the ribosome flow model with extended objects (RFMEO).
Margaliot, Michael +2 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
An ensemble method to predict target genes and pathways in uveal melanoma
Open Life Sciences, 2018 This work proposes to predict target genes and pathways for uveal melanoma (UM) based on an ensemble method and pathway analyses. Methods: The ensemble method integrated a correlation method (Pearson correlation coefficient, PCC), a causal inference ...
Wei Chao, Wang Lei, Zhang Han
doaj +1 more source
Ontogenic Profile of Gluconeogenic Key Enzyme Gene Expressions in Embryonic Chicken Liver and Muscle
The Journal of Poultry Science, 2013 To elucidate biochemical mechanisms underlining high plasma glucose in chicken embryo, gene expression profile of gluconeogenic key enzymes were characterized.
Tushar K. Roy +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source