Results 41 to 50 of about 2,541,766 (304)

Cascade amplification of therapeutic payloads for cancer immunotherapy

Communications Biology
Achieving sufficient therapeutic payload delivery remains a significant challenge in gene therapy, particularly for cancer immunotherapy, where payload thresholds are critical for efficacy.
Yingzhong Li, Jiayu Wu, Na Li, Maoqing Wu, Zongqi Wang, Jiahe Li, Libin Zhang   +6 more
doaj   +1 more source

Promising leads against lung cancer from the plants in Lamiaceae family [PDF]

BioImpacts
Introduction: Ceaselessly, management of cancer has been the major global challenge for healthcare professionals. As regards, lung cancer (LC) has been introduced as the second most common form of cancer in both men and women, taking the lives of more ...
Alireza Rahimlouy Aghdam, Sanaz Hamedeyazdan   +1 more
doaj   +1 more source

Diversity of RNA-Binding Proteins Modulating Post-Transcriptional Regulation of Protein Expression in the Maturing Mammalian Oocyte

Cells, 2020
The oocyte faces a particular challenge in terms of gene regulation. When oocytes resume meiosis at the end of the growth phase and prior to ovulation, the condensed chromatin state prevents the transcription of genes as they are required.
Marie Christou-Kent, Magali Dhellemmes, Emeline Lambert, Pierre F. Ray, Christophe Arnoult   +4 more
doaj   +1 more source

Analysis of lncRNA and mRNA expression profiles in diabetic peripheral neuropathy based on weighted gene co-expression network analysis

All Life, 2023
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus. Recent studies have explored the involvement of long non-coding RNA (lncRNA) in diabetes, but its specific role in DPN development remains unclear.
Dongdong Yu, Yongkang Wang, Fangqi Ma, Yuxiang Guan, Shu Ye, Guoming Shen, Liangzhen You   +6 more
doaj   +1 more source

Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells. [PDF]

, 2015
The treatment of myocardial infarction is a major challenge in medicine due to the inability of heart tissue to regenerate. Direct reprogramming of endogenous cardiac fibroblasts into functional cardiomyocytes via the delivery of transcription factor ...
Kim, Hyun Jin, Lee, Kunwoo, Lingampalli, Nithya, Murthy, Niren, Tang, Richard, Yu, Pengzhi   +5 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Translational regulation of human papillomavirus mRNAs in carcinogenesis: old questions and new insights

Frontiers in Cell and Developmental Biology
Persistent infection with high-risk human papillomaviruses (HR-HPVs) is a major etiological factor in the development of cervical cancer, which ranks as the fourth leading cause of cancer-related mortality among women worldwide.
Noemi Baranda-Ávila, Giovanna Maldonado, Dora E. Vélez, Greco Hernández, Greco Hernández   +4 more
doaj   +1 more source

CHEMOKINES AND THEIR RECEPTORS EXPRESSION IN BLOOD AND LIVER TISSUE IN CHRONIC HEPATITIS C

Медицинская иммунология, 2014
. Chronic hepatitis C (CHC) is widely spread disease with a long incubation period and weakle expressed clinical features. Pathogenesis of CHC despite of intensive efforts is still unclear.
K. V. Zhdanov, D. А. Gussev, V. S. Chirskiy, К. А. Syssoev, L. А. Yakubovskaya, D. М. Shakhmanov, А. Totolian Areg   +6 more
doaj   +1 more source

Human complement factor H. Two factor H proteins are derived from alternatively spliced transcripts [PDF]

, 1991
The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are ...
Alsenz, Alsenz, Aruffo, Chirgwin, Church, Conrad, Day, Feinberg, Fontaine, Kristensen, Laemmli, Maniatis, McAleer, Misasi, Pangburn, Ripoche, Schulz, Schulz, Schwaeble, Seed, Sim, Towbin, Whaley, Whaley   +23 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source