Results 21 to 30 of about 2,084,278 (307)

Quantification of pre-mRNA escape rate and synergy in splicing [PDF]

, 2014
Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape the nucleus with a retained intron. Intron retention can control gene expression and increase proteome diversity.
Becskei, Attila, Bonde, M. (M) M. (M), Becskei, A. (A), Baudrimont, A. (A), Séraphin, B. (Bertrand), Mi Bonde, Marie, Voegeli, Sylvia, Bonde, Marie Mi, Baudrimont, Antoine, Voegeli, S. (S), Séraphin, Bertrand, Voegeli, S, Baudrimont, A, Becskei, A, Voegeli S, Séraphin B, Becskei A, Baudrimont A, Bonde MM   +18 more
core   +1 more source

Identification of Candidate mRNA Genes and Their Potential MicroRNA Targets in Lung Cancer Induced by Smoking Tobacco

Frontiers in Bioscience-Scholar, 2023
Background: Smoking is considered the single highest risk factor for lung cancer and has been suggested to be associated with accelerated somatic mutations in respiratory mucosa that lead to the development of lung cancer.
Amresh Kumar Mishra, Neha Mumtaz, Maneesh Kumar Misra   +2 more
doaj   +1 more source

A cytoplasmic complex mediates specific mRNA recognition and localization in yeast [PDF]

, 2011
In eukaryotes, hundreds of mRNAs are localized by specialized transport complexes. For localization, transcripts are recognized by RNA-binding proteins and incorporated into motor-containing messenger ribonucleoprotein particles (mRNPs).
Henning Urlaub, Cramer, P., Andreas Mayer, Kramer, Katharina, Niessing, Dierk, Jansen, R., Urlaub, Henning, Heym Roland Gerhard, Heym, R. G., Schmid, M., Mueller, M., Heym, R.G., Müller, Marisa, Schmid Maria, Jansen Ralf-Peter, Cramer Patrick, Niessing, D., Roland Gerhard Heym, Kramer, K., Meyer, A., Urlaub Henning, Mayer, A., Müller Marisa, Jansen, Ralf-Peter, Jansen, R.P., Mayer Andreas, Maria Schmid, Cramer, Patrick, Schmid, Maria, Patrick Cramer, Urlaub, H., Katharina Kramer, Jansen, R.-P., Niessing Dierk, Ralf-Peter Jansen, Kramer Katharina, Müller, M., Heym, R., Mayer, Andreas, Dierk Niessing, Heym, Roland Gerhard, Marisa Müller   +41 more
core   +2 more sources

mRNA-LNP dose titration experiment.

, 2022
A. and B. WT animals were injected with increasing doses of mRNA-LNP coding for PR8 HA, or PBS or 10 μg of mRNA. Fourteen days later the B cell responses in the skin draining lymph nodes were determined using flow cytometry. C.
Sonya Jacobsen (11993940), Holly Ramage (10049353), Sonia Ndeupen (11993937), Leila Zabihi Diba (10451835), Nicholas E. Powers (8785298), Drishya Kurup (3842464), Botond Z. Igyártó (6740036), Zhen Qin (411748), Christopher Herbst (6437990), Aurélie Bouteau (6740024), Zachary Hutchins (11993943), Megan Watson (11993946)   +11 more
core   +1 more source

The mRNA encoding the yeast ARE-binding protein Cth2 is generated by a novel 3 ' processing pathway [PDF]

, 2008
Microarray analyses of mRNAs over-expressed in strains lacking the nuclear exosome component Rrp6 identified the transcript encoding the ARE-binding protein Cth2, which functions in cytoplasmic mRNA stability.
Bohnsack, Markus T., Tollervey, David, Ciais, Delphine   +2 more
core   +1 more source

Tetracycline aptamer-controlled regulation of pre-mRNA splicing in yeast [PDF]

, 2007
Splicing of pre-mRNA is a critical step in mRNA maturation and disturbances cause several genetic disorders. We apply the synthetic tetracycline (tc)-binding riboswitch to establish a gene expression system for conditional tc-dependent control of pre ...
Weigand, Julia E., Suess, Beatrix, Weigand, Julia, Süß, Beatrix   +3 more
core   +1 more source

Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay [PDF]

, 2012
5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes (LT), a group of inflammatory lipid mediators derived from arachidonic acid.
Laura Pufahl (182448), Manuel Grez, Grez, Manuel, Ochs, Meike J., Sorg, Bernd L., Beatrix Suess (17019), Sorg Bernd L., Laura Pufahl, Sorg, Bernd Lothar, Bernd L Sorg, Beatrix Suess, Bernd L. Sorg (182441), Suess Beatrix, Grez Manuel, Steinhilber Dieter, Dieter Steinhilber (182458), Meike J. Ochs (182432), Suess, Beatrix, Manuel Grez (182453), Dieter Steinhilber, Meike J Ochs, Pufahl, Laura, Süß, Beatrix, Pufahl Laura, Ochs, Meike, Steinhilber, Dieter, Ochs Meike J.   +26 more
core   +2 more sources

piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm

Nature Communications, 2017
In Drosophila embryos, Piwi-interacting RNAs (piRNAs) loaded into the PIWI protein Aubergine target and destabilize maternal mRNAs. Here, the authors provide evidence that piRNAs and Aubergine cooperate with the Wispy poly(A) polymerase to stabilize ...
Jérémy Dufourt, Gwénaëlle Bontonou, Aymeric Chartier, Camille Jahan, Anne-Cécile Meunier, Stéphanie Pierson, Paul F. Harrison, Catherine Papin, Traude H. Beilharz, Martine Simonelig   +9 more
doaj   +1 more source

In vivo Imaging of oskar mRNA transport reveals the mechanism of posterior localization [PDF]

, 2008
oskar mRNA localization to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Although this localization requires microtubules and the plus end-directed motor, kinesin, its mechanism is controversial and ...
Gilchrist, Michael J., Davis, Ilan, Zimyanin, Vitaly L., Clark, Alejandra, Pecreaux, Jacques, St Johnston, Daniel, Belaya, Katsiaryna   +6 more
core   +1 more source

Polyester materials for mRNA delivery

Exploration of Targeted Anti-tumor Therapy, 2022
Messenger RNA (mRNA) has recently made important progress in clinical implementation, offering a promising therapeutic option for infectious disease and cancer. However, the nature of mRNA molecules rendered them poorly bioavailable and unstable in vivo,
Wang Chen, Yonghui Ma, Xiaoxuan Liu, Dandan Zhu   +3 more
doaj   +1 more source