Results 21 to 30 of about 577,427 (256)
In vivo Imaging of oskar mRNA transport reveals the mechanism of posterior localization [PDF]
, 2008 oskar mRNA localization to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Although this localization requires microtubules and the plus end-directed motor, kinesin, its mechanism is controversial and ...
Zimyanin, Vitaly L +16 more
core +1 more source
Tetracycline aptamer-controlled regulation of pre-mRNA splicing in yeast [PDF]
, 2007 Splicing of pre-mRNA is a critical step in mRNA maturation and disturbances cause several genetic disorders. We apply the synthetic tetracycline (tc)-binding riboswitch to establish a gene expression system for conditional tc-dependent control of pre ...
Weigand, Julia E. +3 more
core +1 more source
A cytoplasmic complex mediates specific mRNA recognition and localization in yeast [PDF]
, 2011 In eukaryotes, hundreds of mRNAs are localized by specialized transport complexes. For localization, transcripts are recognized by RNA-binding proteins and incorporated into motor-containing messenger ribonucleoprotein particles (mRNPs).
Henning Urlaub +41 more
core +2 more sources
mRNA distribution in skeletal muscle is associated with mRNA size [PDF]
Journal of Cell Science, 2021 ABSTRACT Skeletal muscle myofibers are large and elongated cells with multiple and evenly distributed nuclei. Nuclear distribution suggests that each nucleus influences a specific compartment within the myofiber and implies a functional role for nuclear positioning. Compartmentalization of specific mRNAs and proteins has been reported at
Helena Pinheiro +6 more
openaire +2 more sources
The mRNA encoding the yeast ARE-binding protein Cth2 is generated by a novel 3 ' processing pathway [PDF]
, 2008 Microarray analyses of mRNAs over-expressed in strains lacking the nuclear exosome component Rrp6 identified the transcript encoding the ARE-binding protein Cth2, which functions in cytoplasmic mRNA stability.
Bohnsack, Markus T. +2 more
core +1 more source
, 2021 Increases in the world’s population and population density promote the spread of emerging pathogens. Vaccines are the most cost-effective means of preventing this spread.
Fred Zepp +5 more
core +1 more source
Not so cold! Improving the thermostability of mRNA vaccines
Expert Review of VaccinesIntroduction One of the biggest challenges in the mRNA-LNP vaccine field is product stabilization to overcome the logistical hurdles linked to the ultra-cold distribution chain associated with first-generation mRNA SARS-CoV-2 vaccines.
Jean Haensler +7 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2021 Introduction The aim of the study was to investigate the prevalence and severity of adverse reactions (ARs) after immunization of healthcare workers (HCWs) with BNT162b2 vaccine and to associate them with clinical and epidemiological characteristics ...
Filippos Filippatos +5 more
doaj +1 more source
mRNA-LNP dose titration experiment.
, 2022 A. and B. WT animals were injected with increasing doses of mRNA-LNP coding for PR8 HA, or PBS or 10 μg of mRNA. Fourteen days later the B cell responses in the skin draining lymph nodes were determined using flow cytometry. C.
Sonya Jacobsen (11993940) +11 more
core +1 more source