Results 21 to 30 of about 1,902,766 (313)

A cytoplasmic complex mediates specific mRNA recognition and localization in yeast [PDF]

open access: yes, 2011
In eukaryotes, hundreds of mRNAs are localized by specialized transport complexes. For localization, transcripts are recognized by RNA-binding proteins and incorporated into motor-containing messenger ribonucleoprotein particles (mRNPs).
Henning Urlaub   +41 more
core   +1 more source

mRNA-Based Vaccines

open access: yes, 2021
Increases in the world’s population and population density promote the spread of emerging pathogens. Vaccines are the most cost-effective means of preventing this spread.
Fred Zepp   +5 more
core   +1 more source

mRNA-LNP dose titration experiment.

open access: yes, 2022
A. and B. WT animals were injected with increasing doses of mRNA-LNP coding for PR8 HA, or PBS or 10 μg of mRNA. Fourteen days later the B cell responses in the skin draining lymph nodes were determined using flow cytometry. C.
Sonya Jacobsen (11993940)   +11 more
core   +1 more source

The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation [PDF]

open access: yes, 2003
Cleavage and polyadenylation factor (CPF) is a multi-protein complex that functions in pre-mRNA 3'-end formation and in the RNA polymerase II (RNAP II) transcription cycle.
Sadowski, Martin   +7 more
core   +1 more source

Systemic movement of FT mRNA and a possible role in floral induction [PDF]

open access: yes, 2012
FLOWERING LOCUS T (FT) protein is known to be part of the mobile flowering inducing “florigen” signal in plants, but it may not be acting alone. This article reviews the data that FT mRNA can also move systemically throughout the plant and into the shoot
Hong, Yiguo   +5 more
core   +1 more source

Association of clinical and epidemiological characteristics with COVID-19 BNT162b2 mRNA vaccine short-term adverse reactions in healthcare workers

open access: yesHuman Vaccines & Immunotherapeutics, 2021
Introduction The aim of the study was to investigate the prevalence and severity of adverse reactions (ARs) after immunization of healthcare workers (HCWs) with BNT162b2 vaccine and to associate them with clinical and epidemiological characteristics ...
Filippos Filippatos   +5 more
doaj   +1 more source

Polymer library for mRNA delivery

open access: yes, 2022
1
KIM, WON JONG
core  

Not so cold! Improving the thermostability of mRNA vaccines

open access: yesExpert Review of Vaccines
Introduction One of the biggest challenges in the mRNA-LNP vaccine field is product stabilization to overcome the logistical hurdles linked to the ultra-cold distribution chain associated with first-generation mRNA SARS-CoV-2 vaccines.
Jean Haensler   +7 more
doaj   +1 more source

Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay

open access: yes, 2012
5-Lipoxygenase (5-LO) catalyzes the two initial steps in the biosynthesis of leukotrienes (LT), a group of inflammatory lipid mediators derived from arachidonic acid.
Laura Pufahl (182448)   +26 more
core   +1 more source

Myc and mRNA capping

open access: yesBiochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2015
c-Myc is upregulated in response to growth factors and transmits the signal to proliferate by altering the gene expression landscape. When genetic alterations result in growth factor-independent c-Myc expression, it can become an oncogene. The majority of human tumour types exhibit a degree of c-Myc deregulation, resulting in unrestrained cell ...
Dunn, Sianadh, Cowling, Victoria H.
openaire   +3 more sources

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