Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex [PDF]
, 2023 Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation.
Hall, Michael +2 more
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Stability of mRNA/DNA and DNA/DNA duplexes affects mRNA transcription. [PDF]
PLoS ONE, 2007 Nucleic acids, due to their structural and chemical properties, can form double-stranded secondary structures that assist the transfer of genetic information and can modulate gene expression.
Rayna I Kraeva +5 more
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PABPC1——mRNA stability, protein translation and tumorigenesis
Frontiers in Oncology, 2022 Mammalian poly A-binding proteins (PABPs) are highly conserved multifunctional RNA-binding proteins primarily involved in the regulation of mRNA translation and stability, of which PABPC1 is considered a central regulator of cytoplasmic mRNA homing and ...
Ya Qi, Min Wang, Qi Jiang
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Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. [PDF]
, 2010 Kaposi's sarcoma (KS) is the most common cancer among HIV-positive patients. Histogenetic origin of KS has long been elusive due to a mixed expression of both blood and lymphatic endothelial markers in KS tumor cells.
Kafka, Darren +37 more
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Regulation of mRNA stability via BRF1 and other AU-binding proteins [PDF]
, 2005 Steady state levels of mRNAs are determined by the rate of synthesis and degradation. A well-known cis-element conferring instability to mRNA is the so-called AU-rich element (ARE), which is present in the 3’ untranslated region (3’UTR) of many cytokines,
Schmidlin-Stalder, Martin
core +1 more source
The link between adjacent codon pairs and mRNA stability
BMC Genomics, 2017 Background Evidence in diverse organisms suggests that codon optimality is a major determinant of mRNA translation and degradation. Codon optimality is thought to act by modulating the efficiency of ribosome elongation.
Yuriko Harigaya, Roy Parker
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The mRNA encoding the yeast ARE-binding protein Cth2 is generated by a novel 3 ' processing pathway [PDF]
, 2008 Microarray analyses of mRNAs over-expressed in strains lacking the nuclear exosome component Rrp6 identified the transcript encoding the ARE-binding protein Cth2, which functions in cytoplasmic mRNA stability.
Bohnsack, Markus T. +2 more
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Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells
OncoImmunology, 2019 Protective T cell responses against tumors require the production of Interferon gamma (IFN-γ). However, tumor-infiltrating T cells (TILs) gradually lose their capacity to produce IFN-γ and therefore fail to clear malignant cells.
Fiamma Salerno +5 more
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On the role of ras and BRF1 in the regulation of ARE-dependent mRNA-turnover [PDF]
, 2004 Stability of the mRNAs of cytokines, chemokines, growth-factors, protooncogenes and others are regulated via an AU-rich element (ARE) in their 3’ untranslated region (UTR).
Leuenberger, Sabrina Angélique
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The Kaposi’s sarcoma-associated herpesvirus ORF57 protein and its multiple roles in mRNA biogenesis
Frontiers in Microbiology, 2012 Post-transcriptional events which regulate mRNA biogenesis are fundamental to the control of gene expression. A nascent mRNA is therefore steered through multimeric RNA-protein complexes that mediate its capping, splicing, polyadenylation, nuclear export
Brian R Jackson +2 more
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