The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer [PDF]
, 2015 RNA-binding proteins (RBPs) are increasingly identified as post-transcriptional drivers of cancer progression. The RBP LARP1 is an mRNA stability regulator, and elevated expression of the protein in hepatocellular and lung cancers is correlated with ...
Blagden, S +3 more
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The Kaposi’s sarcoma-associated herpesvirus ORF57 protein and its multiple roles in mRNA biogenesis
Frontiers in Microbiology, 2012 Post-transcriptional events which regulate mRNA biogenesis are fundamental to the control of gene expression. A nascent mRNA is therefore steered through multimeric RNA-protein complexes that mediate its capping, splicing, polyadenylation, nuclear export
Brian R Jackson +2 more
doaj +1 more source
Translation Initiation Control of RNase E-Mediated Decay of Polycistronic gal mRNA
Frontiers in Molecular Biosciences, 2020 In bacteria, mRNA decay is a major mechanism for regulating gene expression. In Escherichia coli, mRNA decay initiates with endonucleolytic cleavage by RNase E. Translating ribosomes impede RNase E cleavage, thus providing stability to mRNA.
Heung Jin Jeon +6 more
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Ornithine Decarboxylase mRNA is Stabilized in an mTORC1-dependent Manner in Ras-transformed Cells [PDF]
, 2012 Upon Ras activation, ODC (ornithine decarboxylase) is markedly induced, and numerous studies suggest that ODC expression is controlled by Ras effector pathways. ODC is therefore a potential target in the treatment and prevention of Ras-driven tumours. In
Albig +51 more
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Genomic run-on evaluates transcription rates for all yeast genes and identifies gene regulatory mechanisms [PDF]
, 2004 Most studies of eukaryotic gene regulation have been done looking at mature mRNA levels. Nevertheless, the steady-state mRNA level is the result of two opposing factors: transcription rate (TR) and mRNA degradation.
Albig +37 more
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Long Non-coding RNAs in the Cytoplasm
Genomics, Proteomics & Bioinformatics, 2016 An enormous amount of long non-coding RNAs (lncRNAs) transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs.
Farooq Rashid, Abdullah Shah, Ge Shan
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Hopf bifurcation in a gene regulatory network model: Molecular movement causes oscillations [PDF]
, 2015 Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes.
Chaplain, M, Ptashnyk, M, Sturrock, M
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Expression of inflammation-related genes is associated with adipose tissue location in horses [PDF]
, 2013 Background : In humans, adipose tissue (AT) originating from different depots shows varying gene expression profiles. In horses, the risk of certain metabolic disorders may also be influenced by the impact of specific AT depots.
Bruynsteen, Lien +6 more
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The CAF1-NOT complex of trypanosomes
Frontiers in Genetics, 2014 In African trypanosomes, there is no control of transcription initiation by RNA polymerase II at the level of individual protein-coding genes. Transcription is polycistronic, and individual mRNAs are excised by trans splicing and polyadenylation.
Esteban eErben +2 more
doaj +1 more source
RNA Stability Measurements Using RT-qPCR in Arabidopsis Seedlings
Bio-Protocol, 2020 Steady-state mRNA levels are determined by both the rates of transcription and degradation. Regulation of mRNA stability and/or degradation are key factors that can significantly affect mRNA levels and its biological functions.
Tianran Jia, Brandon Le
doaj +1 more source