Results 21 to 30 of about 3,122,867 (388)

GraphProt: modeling binding preferences of RNA-binding proteins [PDF]

Genome Biology, 2014
We present GraphProt, a computational framework for learning sequence- and structure-binding preferences of RNA-binding proteins (RBPs) from high-throughput experimental data.
Daniel Maticzka, Fabrizio Costa, Rolf Backofen, Sita J Lange   +3 more
core   +5 more sources

RNA-binding proteins as versatile metabolic regulators [PDF]

npj Metabolic Health and Disease
Metabolic shifts are a hallmark of numerous biological processes, including the differentiation of stem cells along a specific lineage and the activation of diverse cell types, such as immune cells.
Ellie Koletsou, Ina Huppertz
doaj   +2 more sources

RNA-binding proteins: modular design for efficient function

Nature Reviews Molecular Cell Biology, 2007
B. M. Lunde, C. Moore, G. Varani
semanticscholar   +3 more sources

RNA buffers the phase separation behavior of prion-like RNA binding proteins

Science, 2018
Shovamayee Maharana, Jie Wang, D. Papadopoulos, Doris Richter, A. Pozniakovsky, I. Poser, M. Bickle, Sandra Rizk, Jordina Guillén-Boixet, Titus M. Franzmann, Marcus Jahnel, Lara Marrone, Young‐Tae Chang, J. Sterneckert, P. Tomančák, A. Hyman, S. Alberti   +16 more
semanticscholar   +3 more sources

The role of disorder in RNA binding affinity and specificity [PDF]

Open Biology, 2020
Most RNA-binding modules are small and bind few nucleotides. RNA-binding proteins typically attain the physiological specificity and affinity for their RNA targets by combining several RNA-binding modules.
Diana S. M. Ottoz, Luke E. Berchowitz
doaj   +1 more source

RNA-binding proteins in human genetic disease

Nature Reviews Genetics, 2020
F. Gebauer, T. Schwarzl, J. Valcárcel, M. Hentze   +3 more
semanticscholar   +3 more sources

RNA binding proteins in MLL-rearranged leukemia

Experimental Hematology & Oncology, 2022
RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene expression regulators in both normal development and disease.
Tiffany M. Tran, Dinesh S. Rao
doaj   +1 more source

Reciprocal regulation of protein synthesis and carbon metabolism for thylakoid membrane biogenesis [PDF]

, 2013
Metabolic control of gene expression coordinates the levels of specific gene products to meet cellular demand for their activities. This control can be exerted by metabolites acting as regulatory signals and/or a class of metabolic enzymes with dual ...
Bohne, Alexandra-Viola, Lidschreiber, Michael, Nickelsen, Jörg, Piotrowski, Markus, Schottkowski, Marco, Schwarz, Christian, Zerges, William   +6 more
core   +8 more sources

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation

eLife, 2021
TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43 by its structured N-terminal and intrinsically disordered C-terminal domains has ...
Juan Carlos Rengifo-Gonzalez, Krystel El Hage, Marie-Jeanne Clément, Emilie Steiner, Vandana Joshi, Pierrick Craveur, Dominique Durand, David Pastré, Ahmed Bouhss   +8 more
doaj   +1 more source

RNA-binding proteins: TRAPping RNA bases [PDF]

Current Biology, 2000
In Bacillus subtilis, tryptophan biosynthesis is regulated by a mechanism called attenuation. The new crystal structure of the 'trp RNA binding attenuation protein', TRAP, in complex with RNA has provided new structural insights into how proteins can bind RNA to regulate transcription and translation.
Muto, Yutaka, Oubridge, Chris, Nagai, Kiyoshi   +2 more
openaire   +2 more sources