Results 131 to 140 of about 2,120 (152)
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Human Molecular Genetics, 1995
A search for genes with sequence homologies to the FMR1 gene resulted in the isolation of mouse and human homologues of the recently described FXR1 gene. The mouse FXR1 gene shares amino acid identity and similarity of 99.1% and 99.6%, respectively, with the human FXR1 gene and amino acid identify and similarity of 67.3% and 79.5% respectively, with ...
J F, Coy +7 more
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A search for genes with sequence homologies to the FMR1 gene resulted in the isolation of mouse and human homologues of the recently described FXR1 gene. The mouse FXR1 gene shares amino acid identity and similarity of 99.1% and 99.6%, respectively, with the human FXR1 gene and amino acid identify and similarity of 67.3% and 79.5% respectively, with ...
J F, Coy +7 more
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The Role of FXR1 and Senescence in Vascular Biology and Intimal Hyperplasia
The FASEB Journal, 2022Introduction Despite the advent of stents, intimal hyperplasia subsequent to vascular interventional procedures remains a major obstacle to success. Vascular smooth muscle cells (VSMC) play a critical role in the development and pathogenesis of intimal hyperplasia indicative of restenosis; therefore regulation ...
Cali Corbett +6 more
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Abstract 1463: Fxr1 is an oncogenic driver in ovarian cancer
Cancer Research, 2023Abstract Introduction: Ovarian cancer is primarily driven by copy number variations, mutations in p53, BRCA1 or BRCA2 genes. Using the single nucleotide polymorphism (SNP) array data of The Cancer Genome Atlas (TCGA), we identified that FXR1 (Fragile X-Related protein 1), which is in the 3q26.3 chromosomal locus is either amplified or ...
Jasmine George +9 more
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FXR1 Decreases Blood Pressure by Regulating Vascular Contractility
The FASEB Journal, 2022Introduction Hypertension is a major risk factor for cardiovascular disease and stroke. Optimally treated hypertensive patients still have a 50% greater cardiovascular risk than untreated normotensive subjects.
Amanda St. Paul +8 more
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Abstract 13125: The Role of FXR1 and Cellular Senescence in Vascular Pathology
Circulation, 2021Introduction: Despite the advent of stents, intimal hyperplasia subsequent to vascular interventional procedures remains a major obstacle to success. Vascular smooth muscle cells (VSMC) play a critical role in the development and pathogenesis of intimal hyperplasia indicative of restenosis; therefore regulation of gene ...
Cali Corbett +5 more
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The RNA-binding protein FXR1 modulates prostate cancer progression by regulating FBXO4
Functional and Integrative Genomics, 2019This paper is to characterize the expression status of Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1) in prostate cancer cells and understand its mechanistic involvement in the tumor biology of prostate cancer. The relative expression of FXR1 in prostate cancer cells was determined by real-time polymerase chain reaction and Western blotting ...
, Yigeng Feng, Renjie Gao
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FMR1/FXR1 and the miRNA pathway are required for eye and neural crest development
Developmental Biology, 2010 FMR1 and FXR1 are RNA binding proteins interacting with the miRNA-induced silencing complex, RISC. Here we describe for the first time the function of these proteins during eye and neural crest (NC) development in Xenopus laevis. A loss of FMR1 or FXR1 results in abnormal eye development as well as defects in cranial cartilage derived from cranial NC ...
Gessert, Susanne +4 more
exaly +3 more sources
The Role of FXR1 in Vascular Smooth Muscle Cytoskeletal Dynamics
2023Appropriate cytoskeletal organization and protein-protein interactions are essential for vascular smooth muscle cell (VSMC) physiological processes relevant to hypertensive conditions. Proteins that link actin dynamics and post-transcriptional mRNA metabolism potentially have a high impact on VSMC pathophysiological processes.
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FXR1 Expression Profiles In Pediatric Rhabdomyosarcoma
Pediatrics, 2021Mark C. Xu +6 more
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FXR1 Drives Oncogenic Transformation Through Regulation of Translation
2013Cells use translation to respond quickly and robustly to many different situations. Eukaryotic translation is not only controlled globally but can be as specific as a single mRNA transcript allowing a massive response or fine tuning by the cell. Cancer is a complex disease with much genetic variation, but commonly deregulates translation to further ...
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