Results 111 to 120 of about 2,417 (183)

FXR1 is overexpressed in head and neck squamous cell carcinoma.

, 2016
(A) Comparison of altered copy number and mRNA expression level of RBPs in TCGA HNSCC data sets. (B) Percent mRNA expression level of top altered RBPs in 279 TCGA HNSCC tumor samples.
Nallasivam Palanisamy (265021), Mrinmoyee Majumder (3110004), Reniqua House (3109998), J. Alan Diehl (3109995), Shuo Qie (3110010), Viswanathan Palanisamy (255208), Terrence A. Day (3110001), David Neskey (3110007)   +7 more
core   +1 more source

Modeling Fragile X Syndrome in Drosophila

Frontiers in Molecular Neuroscience, 2018
Intellectual disability (ID) and autism are hallmarks of Fragile X Syndrome (FXS), a hereditary neurodevelopmental disorder. The gene responsible for FXS is Fragile X Mental Retardation gene 1 (FMR1) encoding the Fragile X Mental Retardation Protein ...
Małgorzata Drozd, Małgorzata Drozd, Barbara Bardoni, Barbara Bardoni, Maria Capovilla, Maria Capovilla   +5 more
doaj   +1 more source

Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo.

, 2004
FXR1 is one of the two known homologues of FMR1. FXR1 shares a high degree of sequence homology with FMR1 and also encodes two KH domains and an RGG domain, conferring RNA-binding capabilities.
Hoogeveen-Westerveld, M. (Marianne), Nieuwenhuizen, Ingeborg M., Nieuwenhuizen, I.M. (Ingeborg), Kirkpatrick, L.L. (Laura), Kirkpatrick, Laura L., Mientjes, Edwin J., Oostra, Ben A., Hoogeveen, A.T. (Andre), Verweij, Marcel, Reis, Surya, Bardoni, Barbara, Bardoni, B. (Barbara), Mientjes, E.J. (Edwin), Willemsen, R. (Rob), Oostra, B.A. (Ben), Nelson, David L., Reis, S. (Surya), Nelson, D.L. (David), Hoogeveen-Westerveld, Marianne, Willemsen, Rob, Verweij, M. (Marcel), Hoogeveen, Andre T.   +21 more
core   +1 more source

Two members of the Fxr gene family, Fmr1 and Fxr1, are differentially expressed in Xenopus tropicalis

The International Journal of Developmental Biology, 2005
The Fxr gene family is composed of three members, FMR1, FXR1 and FXR2. The FMR1 gene is involved in the fragile X syndrome, whereas for the other two members, no human disorder has been identified yet. An appropriate animal model to study in vivo gene function is essential to unravel the cellular function of the gene products FMRP, FXR1P and FXR2P ...
Blonden, Lau, Padje, SV, Severijnen, Lies-anne, Destree, O, Oostra, Ben, Willemsen, Rob   +5 more
openaire   +3 more sources

Regulation of glutamatergic neurotransmission, synaptic plasticity, sleep and behavior by D2-GSK3B-FXR1

, 2020
Les études GWAS associent les variantes du gène Fxr1 à la schizophrénie, les maladies bipolaires, l’insomnie et la durée du sommeil. Gsk3β peut directement phosphoryler et ainsi réguler négativement Fxr1.
Khlghatyan, Jivan
core  

Validation of anti-FXR1 antibodies in the canine species and application to an immunohistochemical study of canine oral melanomas

, 2017
FXR1 (Fragile X mental retardation-related protein 1) is a cytoplasmic RNA binding protein, which genetic expression has been related to metastatic potential in human melanoma.
Marques, Andreia Filipa Tomas, Nordio, Laura, L. Nordio, A.F. Tomas Marques   +3 more
core   +1 more source

Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis

Communications Biology
The prevalent RNA alternative splicing (AS) contributes to molecular diversity, which has been demonstrated in cellular function regulation and disease pathogenesis. However, the contribution of AS in pancreatic islets during diabetes progression remains
Jin Wang, Shiyi Wen, Minqi Chen, Jiayi Xie, Xinhua Lou, Haihan Zhao, Yanming Chen, Meng Zhao, Guojun Shi   +8 more
doaj   +1 more source

Fragile X-related protein 1 (FXR1) regulates cyclooxygenase-2 (COX-2) expression at the maternal–fetal interface

, 2018
Cyclooxygenase-2 (COX-2) is regulated post-transcriptionally by the AU-rich element (ARE) in the 3′-untranslated region (UTR) of its mRNA. However, the mechanism of COX-2 induction in infertility has not been thoroughly elucidated to date.
Meng-fan Song, Fu-Ju Tian, Bei-ying Wang, Yu-mei Wang, Feng Sun, Xiao-Cui Li, Jin-Hong Chen   +6 more
core   +1 more source

LTA4H and FXR1 Gene and Protein Expression in Canine Oral Melanoma [PDF]

, 2017
Introduction: Canine oral melanoma is a common neoplasm that is usually considered malignant, although the correlation between histology and prognosis is still controversial. Therefore, research of new biological markers is ongoing. In this study, LTA4H (
C. Bazzocchi, C. Giudice, V. Serra, D. Stefanello, M. Rondena, F. Genova, M. L. Longeri, L. Nordio   +7 more
core  

Rare case of congenital myopathy associated with the FXR1 gene

Arquivos de Neuro-Psiquiatria, 2023
Isadora Cavalcante Olímpio de Melo, Paula Luisa Lopes Shell, Ana Carolina Jorge Fogolin, Michelle Basso Couto Gouveia, Iris do Vale Miranda, Helen Ramos Vasoncelos, Ana Elisa Ribeiro de Faria, Rafael Guerra Cintra   +7 more
openaire   +1 more source