Results 91 to 100 of about 2,644 (175)

Global gene expression profiling reveals a suppressed immune response pathway associated with 3q amplification in squamous carcinoma of the lung

Genomics Data, 2015
Chromosome 3q26–28 is a critical region of genomic amplification in non-small cell lung cancer (NSCLC), particularly lung squamous cell carcinomas (SCCs).
Jun Qian, Yong Zou, Jing Wang, Bing Zhang, Pierre P. Massion   +4 more
doaj   +1 more source

RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications

MedComm, Volume 6, Issue 8, August 2025.
RNA epigenetics regulates cancer through RNA modifications, splicing, transport, and translation. Key components include m⁶A writers, splicing factors, RBPs, and nuclear export machinery. Aberrant RNA metabolism drives tumor progression and immune evasion.
Shanhe Huang, Zonglin Li, Weilong Lin, Ruihui Xie, Hai Huang   +4 more
wiley   +1 more source

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Genes and pathways differentially expressed in the brains of Fxr2 knockout mice

Neurobiology of Disease, 2008
Fragile X syndrome is a common inherited form of mental retardation and originates from the absence of expression of the FMR1 gene. This gene and its two homologues, FXR1 and FXR2, encode for a family of fragile X related (FXR) proteins with similar ...
Sebastiano Cavallaro, Sabrina Paratore, Francesco Fradale, Femke M.S. de Vrij, Rob Willemsen, Ben A. Oostra   +5 more
doaj   +1 more source

Comparative Genomic Sequence Analysis of the FXR Gene Family: FMR1, FXR1, and FXR2

Genomics, 2001
Mutations in the X-linked gene FMR1 cause fragile X syndrome, the leading cause of inherited mental retardation. Two autosomal paralogs of FMR1 have been identified, and are known as FXR1 and FXR2. Here we describe and compare the genomic structures of the mouse and human genes FMR1, FXR1, and FXR2. All three genes are very well conserved from mouse to
L L, Kirkpatrick, K A, McIlwain, D L, Nelson   +2 more
openaire   +2 more sources

FXR1 binds to miR301a-3p in vivo and in vitro.

, 2020
(A) RNA-immunoprecipitation shows miRNA301a-3p binds to FXR1 in UMSCC74B cells compared to control mouse IgG. Both ACTIN and RPS18 served as endogenous controls. FXR1 antibody pull-down efficiency by immunoprecipitation is shown in the inset.
Mrinmoyee Majumder (3110004), Viswanathan Palanisamy (255208)   +1 more
core   +1 more source

The FXR1 network acts as signaling scaffold for actomyosin remodeling. Chen et al. 2024

It is currently not known whether mRNAs fulfill structural roles in the cytoplasm. Here, we report the FXR1 network, an mRNA-protein (mRNP) network present throughout the cytoplasm, formed by FXR1-mediated packaging of exceptionally long mRNAs.
Chen, Xiuzhen
core   +1 more source

Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo.

, 2004
FXR1 is one of the two known homologues of FMR1. FXR1 shares a high degree of sequence homology with FMR1 and also encodes two KH domains and an RGG domain, conferring RNA-binding capabilities.
Hoogeveen-Westerveld, M. (Marianne), Nieuwenhuizen, Ingeborg M., Nieuwenhuizen, I.M. (Ingeborg), Kirkpatrick, L.L. (Laura), Kirkpatrick, Laura L., Mientjes, Edwin J., Oostra, Ben A., Hoogeveen, A.T. (Andre), Verweij, Marcel, Reis, Surya, Bardoni, Barbara, Bardoni, B. (Barbara), Mientjes, E.J. (Edwin), Willemsen, R. (Rob), Oostra, B.A. (Ben), Nelson, David L., Reis, S. (Surya), Nelson, D.L. (David), Hoogeveen-Westerveld, Marianne, Willemsen, Rob, Verweij, M. (Marcel), Hoogeveen, Andre T., Mientjes, Edwin; id_orcid, Hoogeveen - Westerveld, Marianne, Bardoni, B, Kirkpatrick, L, Oostra, Ben, Nelson, DL, Hoogeveen, Andre, Verweij, Mariëlle, Reis, SA (Surya), Bakker, Ingeborg   +31 more
core   +1 more source

nsP3-FXR co-condensation enables alphavirus replication and reveals a targetable alphavirus vulnerability

Cell Reports
Summary: Alphaviruses are mosquito-borne RNA viruses that pose a significant threat to humans, with risks worsened by global warming. Non-structural protein 3 (nsP3) is critical for alphavirus infection, yet its precise roles remain poorly defined. Using
Yifan Xie, Jie Cao, Xinya Yang, Ruzhu Hou, Suhong Qian, Guojie Wang, Shiyu Deng, Luo-Na Lin, Yue Liu, Peiguo Yang, Rong Zhang, Qiang Ding, Peng Sun, Wenchun Fan   +13 more
doaj   +1 more source

Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes

EMBO Molecular Medicine, 2015
Fragile X syndrome (FXS) is mostly caused by a CGG triplet expansion in the fragile X mental retardation 1 gene (FMR1). Up to 60% of affected males fulfill criteria for autism spectrum disorder (ASD), making FXS the most frequent monogenetic cause of ...
Beata Stepniak, Anne Kästner, Giulia Poggi, Marina Mitjans, Martin Begemann, Annette Hartmann, Sandra Van der Auwera, Farahnaz Sananbenesi, Dilja Krueger‐Burg, Gabriela Matuszko, Cornelia Brosi, Georg Homuth, Henry Völzke, Fritz Benseler, Claudia Bagni, Utz Fischer, Alexander Dityatev, Hans‐Jörgen Grabe, Dan Rujescu, Andre Fischer, Hannelore Ehrenreich   +20 more
doaj   +1 more source