Results 91 to 100 of about 2,417 (183)
Image_4_Molecular and Immunohistochemical Expression of LTA4H and FXR1 in Canine Oral Melanoma.tif
, 2021 Oral melanoma is a common canine tumor whose prognosis is considered ominous, but poorly predicted by histology alone. In the present study the gene and protein expression of Leukotriene A4 hydrolase (LTA4H) and Fragile-X-mental retardation-related ...
Maria Longeri (32277) +8 more
core +1 more source
WIREs RNA, Volume 16, Issue 2, March/April 2025.Stress granules emerging during viral infection can play both pro‐ and antiviral roles. RNA viruses use various strategies to antagonize their formation, including the degradation, inhibition, or sequestration of G3BP1, a key stress granule protein. However, biochemical and structural insights into these mechanisms have been reported for only a handful
Moh Egy Rahman Firdaus +3 more
wiley +1 more source
Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy
Nature Communications, 2019 FXR1P is a RNA binding protein involved in muscle development. Here, the authors show that mutations in FXR1 exon 15, which is alternatively spliced in muscle, cause multi-minicore myopathy in humans and in mouse models.
María Cristina Estañ +29 more
doaj +1 more source
Understanding GEMIN5 Interactions: From Structural and Functional Insights to Selective Translation
WIREs RNA, Volume 16, Issue 2, March/April 2025.GEMIN5 structural domains. Overview of GEMIN5's role in snRNP assembly and translation regulatory events. ABSTRACT GEMIN5 is a predominantly cytoplasmic protein, initially identified as a member of the survival of motor neurons (SMN) complex. In addition, this abundant protein modulates diverse aspects of RNA‐dependent processes, executing its ...
Encarnacion Martinez‐Salas +2 more
wiley +1 more source
SKP1‐CUL1‐F‐box: Key molecular targets affecting disease progression
The FASEB Journal, Volume 39, Issue 2, 31 January 2025.SCF complexes are widely involved in intracellular metabolism. In this paper, we discuss the diverse effects of SCF on crucial cellular processes such as cell cycle progression, cell migration, biological rhythms, DNA replication, cell differentiation, cell, apoptosis, immune response, and disease occurrence.
Xiangrong Zeng +6 more
wiley +1 more source
Genomics Data, 2015 Chromosome 3q26–28 is a critical region of genomic amplification in non-small cell lung cancer (NSCLC), particularly lung squamous cell carcinomas (SCCs).
Jun Qian +4 more
doaj +1 more source
Circadian Regulation of the RNA-binding Protein Fxr1 and its Role in Regulating Core Clock Genes
, 2022 The fragile X autosomal homolog 1 (Fxr1) is an RNA-binding protein that controls mRNA translation and has been associated to mood regulation, schizophrenia, and bipolar disorders.
Soares Silva, Tiago
core
Advanced Science, Volume 12, Issue 2, January 13, 2025.RNA‐binding protein Hnrnpa1 induces Mettl3 post‐transcriptional splicing to inhibit m6A‐dependent Pbx1 and E2F1 degradation, thereby increasing Runx1, Ccne1, Cdk2 and Ccnb2 expression to promote cardiomyocyte dedifferentiation and cell cycle activity. Abstract Stimulating cardiomyocyte (CM) dedifferentiation and cell cycle activity (DACCA) is essential
Chuling Li +17 more
wiley +1 more source
Advanced Science, Volume 12, Issue 3, January 20, 2025.METTL16 predominantly controls the expression of critical meiotic genes essential for DSB formation and recombination in early meiotic spermatocytes and is involved in the expansion of DNA damage response (DDR) factors and epigenetic modifications in the XY body for the establishment and maintenance of meiotic sex chromosome inactivation (MSCI) in ...
Lisha Yin +16 more
wiley +1 more source
Image_2_Molecular and Immunohistochemical Expression of LTA4H and FXR1 in Canine Oral Melanoma.tif
, 2021 Oral melanoma is a common canine tumor whose prognosis is considered ominous, but poorly predicted by histology alone. In the present study the gene and protein expression of Leukotriene A4 hydrolase (LTA4H) and Fragile-X-mental retardation-related ...
Maria Longeri (32277) +8 more
core +1 more source