Results 61 to 70 of about 2,417 (183)

PNPT1 is overexpressed in HNSCC that degrades miR301a-3p in the absence of FXR1.

, 2020
(A) qRT-PCR analysis of FXR1, XRN1, XRN2, and PNPT1 in HNSCC cell lines compared to primary line HOK along with lung cancer cell line A549. Both ACTIN and RPS18 served as endogenous controls. (B) (up) qRT-PCR analyses to test the expression of miR301a-3p
Mrinmoyee Majumder (3110004), Viswanathan Palanisamy (255208)   +1 more
core   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

The Use of “Retardation” in FRAXA, FMRP, FMR1 and Other Designations

Cells, 2022
The European Fragile X Network met in Wroclaw, Poland, November 2021, and agreed to work towards the eradication of the word “retardation” in regard to the naming of the fragile X gene (FRAXA) and protein (FMRP).
Jonathan Herring, Kirsten Johnson, Jörg Richstein   +2 more
doaj   +1 more source

FXR1‐Directed Alternative Splicing of MK5 Drives Hepatocellular Carcinoma Progression by Activating GSK3β Signaling

Cancer Science, Volume 117, Issue 6, Page 1580-1593, June 2026.
The RNA‐binding protein FXR1 promotes hepatocellular carcinoma (HCC) progression by driving alternative splicing of MK5 to generate an oncogenic isoform, MK5‐L, which activates the Wnt/β‐catenin pathway. Targeting FXR1 with an antisense oligonucleotide suppresses tumor growth in vivo, revealing a promising therapeutic strategy for HCC.
Yutong Li, Jin Xiang, Bin Cheng, Chenhao Li, Kai Wang, Ni Tang, Luyi Huang   +6 more
wiley   +1 more source

Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis [PDF]

Human Molecular Genetics, 1997
Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as the major pathological symptoms in fragile X patients. FMRP is a cytoplasmic RNA-binding protein which cosediments with the 60S ribosomal subunit. Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2. These
Tamanini, Filippo, Willemsen, Rob, Unen, L, Bontekoe, CJM (Carola), Galjaard, H, Oostra, Ben, Hoogeveen, Andre   +6 more
openaire   +2 more sources

Uncovering the Genetic Landscape of Spinal Dysraphism: A Retrospective Analysis of 150 Fetal Cases

Prenatal Diagnosis, Volume 46, Issue 5-6, Page 849-861, May 2026.
ABSTRACT Objective Spinal dysraphism (SD) results from incomplete neural tube closure and encompasses a heterogeneous group of congenital anomalies with genetic and environmental etiologies. Although genetic contributions are recognized, causative variants remain insufficiently defined, and the clinical implications of extended genetic testing on ...
I. Bedei, A. Feresin, R. Zemet, D. Berner, D. Polidori, K. Fröbius, A. Skakkebæk, R. Axt‐Fliedner, M. Shoukier, C. Keil   +9 more
wiley   +1 more source

AU-Rich-Element-Mediated Upregulation of Translation by FXR1 and Argonaute 2 [PDF]

Cell, 2007
AU-rich elements (AREs), present in mRNA 3'-UTRs, are potent posttranscriptional regulatory signals that can rapidly effect changes in mRNA stability and translation, thereby dramatically altering gene expression with clinical and developmental consequences.
Vasudevan, Shobha, Steitz, Joan A.
openaire   +2 more sources

Fragile X family members have important and non-overlapping functions

Biomolecular Concepts, 2011
The fragile X family of genes encodes a small family of RNA binding proteins including FMRP, FXR1P and FXR2P that were identified in the 1990s. All three members are encoded by 17 exons and show alternative splicing at the 3′ ends of their respective ...
Winograd Claudia, Ceman Stephanie
doaj   +1 more source

Fragile X–Related Protein 1 Regulates Nucleoporin Localization in a Cell Cycle–Dependent Manner

Frontiers in Cell and Developmental Biology, 2021
Nuclear pore complexes (NPCs) are embedded in the nuclear envelope (NE) where they ensure the transport of macromolecules between the nucleus and the cytoplasm.
Arantxa Agote-Arán, Arantxa Agote-Arán, Arantxa Agote-Arán, Arantxa Agote-Arán, Junyan Lin, Junyan Lin, Junyan Lin, Junyan Lin, Izabela Sumara, Izabela Sumara, Izabela Sumara, Izabela Sumara   +11 more
doaj   +1 more source

Data_Sheet_2_Molecular and Immunohistochemical Expression of LTA4H and FXR1 in Canine Oral Melanoma.PDF

, 2021
Oral melanoma is a common canine tumor whose prognosis is considered ominous, but poorly predicted by histology alone. In the present study the gene and protein expression of Leukotriene A4 hydrolase (LTA4H) and Fragile-X-mental retardation-related ...
Maria Longeri (32277), Chiara Giudice (5050880), Damiano Stefanello (5050877), Francesca Genova (5798174), Valentina Serra (630827), Marco Rondena (11829050), Laura Nordio (5050874), Chiara Bazzocchi (799155), Giovanni Franzo (3574259)   +8 more
core   +1 more source