Results 61 to 70 of about 2,644 (175)
FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells
Journal of Cell Biology, 2020 Fragile-X mental retardation autosomal homologue-1 (FXR1) is a muscle-enriched RNA-binding protein. FXR1 depletion is perinatally lethal in mice, Xenopus, and zebrafish; however, the mechanisms driving these phenotypes remain unclear. The FXR1 gene undergoes alternative splicing, producing multiple protein isoforms and mis-splicing has been implicated ...
Jean A. Smith +13 more
openaire +3 more sources
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.The molecular mechanisms contributing to impaired fertility in HIV+ males remain poorly defined. Using a human immunodeficiency virus (HIV) transgenic (Tg) rat model, we demonstrate key structural and functional sperm regulators including cation channel of sperm (CatSper)1–4 channels and mitochondrial biogenesis genes were markedly downregulated ...
Tousif Ahmed Hediyal +12 more
wiley +1 more source
Connecting the dots between FXR1 isoforms and miR-1 in pediatric dilated cardiomyopathy. [PDF]
Am J Physiol Heart Circ PhysiolShivam P, Gonzalez SB, Nde PN.
europepmc +3 more sources
FMRP‐Mediated Proteasome Regulation: A Novel Mechanism in ALS Pathology
The FASEB Journal, Volume 40, Issue 13, 15 July 2026.Schematic model of TDP‐43/TNKS‐mediated proteasome regulation in WT, FMRP‐depleted, and TDP‐43A315T‐Tg ALS neurons. In WT neurons, cytoplasmic TDP‐43 partially sequesters TNKS, maintaining balanced PI31 ribosylation and proteasome activity. FMRP depletion promotes nuclear translocation of TDP‐43, enhances TNKS/PI31 interaction, and increases axonal ...
Pritha Majumder +5 more
wiley +1 more source
FXR1 engages dual mechanisms to promote malignant transformation in HNSCC.
, 2016 RNA-binding protein FXR1 regulates TERC RNA and p21 mRNA turnover to modulate telomerase activity (left panel) and cell cycle (right panel), respectively, to allow escape from senescence and stimulate transformation.
Erlinda Fernández (382608) +1 more
core +1 more source
Cell Death and DiseaseRNA-binding proteins (RBPs) modulate the expression level of several target RNAs (such as mRNAs) post-transcriptionally through interactions with unique binding sites in the 3′-untranslated region.
Faiz Ali Khan +3 more
doaj +1 more source
Fragile X–Related Protein 1 Regulates Nucleoporin Localization in a Cell Cycle–Dependent Manner
Frontiers in Cell and Developmental Biology, 2021 Nuclear pore complexes (NPCs) are embedded in the nuclear envelope (NE) where they ensure the transport of macromolecules between the nucleus and the cytoplasm.
Arantxa Agote-Arán +11 more
doaj +1 more source
Fxr1 Deletion from Cortical Parvalbumin Interneurons Modifies Their Excitatory Synaptic Responses. [PDF]
eNeuroFragile X autosomal homolog 1 (FXR1), a member of the fragile X messenger riboprotein 1 family, has been linked to psychiatric disorders including autism and schizophrenia. Parvalbumin (PV) interneurons play critical roles in cortical processing and have been implicated in FXR1-linked mental illnesses.
Scheuer KS +4 more
europepmc +3 more sources
Image_1_Molecular and Immunohistochemical Expression of LTA4H and FXR1 in Canine Oral Melanoma.tif
, 2021 Oral melanoma is a common canine tumor whose prognosis is considered ominous, but poorly predicted by histology alone. In the present study the gene and protein expression of Leukotriene A4 hydrolase (LTA4H) and Fragile-X-mental retardation-related ...
Maria Longeri (32277) +8 more
core +1 more source
Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity
Frontiers in Molecular Neuroscience, 2022 Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of lithium ions on mood regulation in bipolar disorder and other mental illnesses, including major depression, cyclothymia, and schizophrenia.
Dipashree Chatterjee +1 more
doaj +1 more source