Results 41 to 50 of about 2,120 (152)

FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses [PDF]

Journal of Radiation Research, 2020
Abstract Ataxia-telangiectasia (AT) and MRE11-defective Ataxia-telangiectasia-like disorder (ATLD) patients show progressive cerebellar ataxia. ATM, mutated in AT, can be activated in response to oxidative stress as well as DNA damage, which could be linked to disease-related neurodegeneration.
Qi, Fei, Meng, Qingmei, Hayashi, Ikue, Kobayashi, Junya   +3 more
openaire   +2 more sources

Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission

Frontiers in Molecular Neuroscience, 2018
Genetic variants of the fragile X mental retardation syndrome-related protein 1 (FXR1) have been associated to mood regulation, schizophrenia, and bipolar disorders.
Jivan Khlghatyan, Jivan Khlghatyan, Alesya Evstratova, Simon Chamberland, Aleksandra Marakhovskaia, Arash Bahremand, Katalin Toth, Jean-Martin Beaulieu, Jean-Martin Beaulieu   +8 more
doaj   +1 more source

Regulation of monocyte induced cell migration by the RNA binding protein, FXR1 [PDF]

Cell Cycle, 2016
FXR1 belongs to a family of RNA-binding proteins that play critical roles in post-transcriptional regulation of gene expression in immunity, development and cancer. FXR1 is associated with regulation of specific mRNAs in myocytes and macrophages. In quiescent cells (> 24 h of extended serum-starvation, ∼30-48 h or more), a spliced isoform of FXR1 ...
O, Le Tonqueze, S, Kollu, S, Lee, M, Al-Salah, S S, Truesdell, S, Vasudevan   +5 more
openaire   +2 more sources

FXR1, an autosomal homolog of the fragile X mental retardation gene. [PDF]

The EMBO Journal, 1995
Fragile X mental retardation syndrome, the most common cause of hereditary mental retardation, is directly associated with the FMR1 gene at Xq27.3. FMR1 encodes an RNA binding protein and the syndrome results from lack of expression of FMR1 or expression of a mutant protein that is impaired in RNA binding.
M C, Siomi, H, Siomi, W H, Sauer, S, Srinivasan, R L, Nussbaum, G, Dreyfuss   +5 more
openaire   +2 more sources

Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis [PDF]

Human Molecular Genetics, 1997
Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as the major pathological symptoms in fragile X patients. FMRP is a cytoplasmic RNA-binding protein which cosediments with the 60S ribosomal subunit. Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2. These
Tamanini, Filippo, Willemsen, Rob, Unen, L, Bontekoe, CJM (Carola), Galjaard, H, Oostra, Ben, Hoogeveen, Andre   +6 more
openaire   +2 more sources

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

AU-Rich-Element-Mediated Upregulation of Translation by FXR1 and Argonaute 2 [PDF]

Cell, 2007
AU-rich elements (AREs), present in mRNA 3'-UTRs, are potent posttranscriptional regulatory signals that can rapidly effect changes in mRNA stability and translation, thereby dramatically altering gene expression with clinical and developmental consequences.
Vasudevan, Shobha, Steitz, Joan A.
openaire   +2 more sources

Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1

Journal of Experimental & Clinical Cancer Research, 2022
Background Although success was achieved in the therapy for a minority of advanced lung adenocarcinoma (LUAD) patients, anti-programmed death 1 (PD1) resistance was found in most LUAD patients.
Jian Gao, Yong-Qiang Ao, Ling-Xian Zhang, Jie Deng, Shuai Wang, Hai-Kun Wang, Jia-Hao Jiang, Jian-Yong Ding   +7 more
doaj   +1 more source

Expression and Prognosis Analysis of SUMOylation Regulators in Oral Squamous Cell Carcinoma Based on High-Throughput Sequencing

Frontiers in Genetics, 2021
IntroductionOral squamous cell carcinoma (OSCC) originates from oral mucosal epithelial cells, accounting for more than 90% of oral cancers. The relationship between the expression and prognostic role of SUMOylation regulators in OSCC is rarely studied ...
Yutong Meng, Xiaozhi Li
doaj   +1 more source

Novel and emerging cutaneous soft tissue tumours

Histopathology, EarlyView.
This review outlines the defining histopathological, immunophenotypic and molecular features of novel and emerging cutaneous soft tissue tumours, including hybrid superficial ALK‐rearranged myxoid spindle cell neoplasm/epithelioid fibrous histiocytoma, superficial neurocristic tumour, ALK‐rearranged epithelioid vascular neoplasm and MITF pathway ...
Saba Shafi, Josephine K Dermawan
wiley   +1 more source