Results 41 to 50 of about 2,417 (183)
, 2021 Raw data of all the Western blots performed for the study titled "RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to translation start ...
Chaluvally-Raghavan, P (via Mendeley Data)
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Alternative Splicing in the Murine and Human FXR1 Genes
Genomics, 1999 Fragile X syndrome results from mutations in the X-linked FMR1 gene. The most common mutation is expansion and hypermethylation of a CGG repeat in the 5'UTR of FMR1, which blocks transcription and results in the loss of FMR1 protein (FMRP). Efforts to understand the function of FMRP have led to the identification of two autosomal homologs, FXR1P and ...
L L, Kirkpatrick +2 more
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Scientific Reports, 2023 The ubiquitin–proteasome system (UPS) is a proteolytic pathway that is essential for life maintenance and vital functions, and its disruption causes serious impairments, e.g., disease development. Thus, the UPS is properly regulated.
Hideo Shimizu, Hirohiko Hohjoh
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FXR1: Linking cellular quiescence, immune genes and cancer [PDF]
Cell Cycle, 2016 Cellular quiescence has been considered a homogeneous passive state wherein cells, in response to certain physiological stimuli, remain dormant until they are signaled to re-enter the cell cycle.
Radhika Raheja, Roopali Gandhi
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EBioMedicine, 2022 Summary: Background: Intestinal barrier dysfunction is crucial in alcohol-associated liver disease (ALD). The decreased beta-Klotho (KLB) expression caused by gene variation is associated with hyperpermeability in patients with irritable bowel syndrome.
Zhengping Hou +11 more
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FXR1 is elevated in colorectal cancer and acts as an oncogene
Tumor Biology, 2015 Fragile X-related gene 1 (FXR1) is deregulated in a variety of human disorders including cancer. However, there is relatively little evidence concerning the relationship between FXR1 and colorectal cancer. Western blot, immunohistochemistry (IHC), and quantitative real-time PCR (qRT-PCR) were adopted to detect the FXR1 protein and messenger RNA (mRNA ...
Xin, Jin +4 more
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A novel role for the RNA-binding protein FXR1P in myoblasts cell-cycle progression by modulating p21/Cdkn1a/Cip1/Waf1 mRNA stability. [PDF]
PLoS Genetics, 2013 The Fragile X-Related 1 gene (FXR1) is a paralog of the Fragile X Mental Retardation 1 gene (FMR1), whose absence causes the Fragile X syndrome, the most common form of inherited intellectual disability.
Laetitia Davidovic +8 more
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RNA-binding protein FXR1 is presented in rat brain in amyloid form [PDF]
Scientific Reports, 2019 AbstractAmyloids are β-sheets-rich protein fibrils that cause neurodegenerative and other incurable human diseases affecting millions of people worldwide. However, a number of proteins is functional in the amyloid state in various organisms from bacteria to humans.
Julia V. Sopova +12 more
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FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses [PDF]
Journal of Radiation Research, 2020 Abstract Ataxia-telangiectasia (AT) and MRE11-defective Ataxia-telangiectasia-like disorder (ATLD) patients show progressive cerebellar ataxia. ATM, mutated in AT, can be activated in response to oxidative stress as well as DNA damage, which could be linked to disease-related neurodegeneration.
Qi, Fei +3 more
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FXR1 binds to miR301a-3p in vivo and in vitro.
, 2020 (A) RNA-immunoprecipitation shows miRNA301a-3p binds to FXR1 in UMSCC74B cells compared to control mouse IgG. Both ACTIN and RPS18 served as endogenous controls. FXR1 antibody pull-down efficiency by immunoprecipitation is shown in the inset.
Mrinmoyee Majumder (3110004) +1 more
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