Results 41 to 50 of about 2,644 (175)
EBioMedicine, 2022 Summary: Background: Intestinal barrier dysfunction is crucial in alcohol-associated liver disease (ALD). The decreased beta-Klotho (KLB) expression caused by gene variation is associated with hyperpermeability in patients with irritable bowel syndrome.
Zhengping Hou +11 more
doaj +1 more source
FXR1 is elevated in colorectal cancer and acts as an oncogene
Tumor Biology, 2015 Fragile X-related gene 1 (FXR1) is deregulated in a variety of human disorders including cancer. However, there is relatively little evidence concerning the relationship between FXR1 and colorectal cancer. Western blot, immunohistochemistry (IHC), and quantitative real-time PCR (qRT-PCR) were adopted to detect the FXR1 protein and messenger RNA (mRNA ...
Xin, Jin +4 more
openaire +2 more sources
A novel role for the RNA-binding protein FXR1P in myoblasts cell-cycle progression by modulating p21/Cdkn1a/Cip1/Waf1 mRNA stability. [PDF]
PLoS Genetics, 2013 The Fragile X-Related 1 gene (FXR1) is a paralog of the Fragile X Mental Retardation 1 gene (FMR1), whose absence causes the Fragile X syndrome, the most common form of inherited intellectual disability.
Laetitia Davidovic +8 more
doaj +1 more source
FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses [PDF]
Journal of Radiation Research, 2020 Abstract Ataxia-telangiectasia (AT) and MRE11-defective Ataxia-telangiectasia-like disorder (ATLD) patients show progressive cerebellar ataxia. ATM, mutated in AT, can be activated in response to oxidative stress as well as DNA damage, which could be linked to disease-related neurodegeneration.
Qi, Fei +3 more
openaire +2 more sources
RNA-binding protein FXR1 is presented in rat brain in amyloid form [PDF]
Scientific Reports, 2019 AbstractAmyloids are β-sheets-rich protein fibrils that cause neurodegenerative and other incurable human diseases affecting millions of people worldwide. However, a number of proteins is functional in the amyloid state in various organisms from bacteria to humans.
Julia V. Sopova +12 more
openaire +2 more sources
FXR1-regulated senescence is irreversible.
, 2016 (A) Relative quantity of FXR1, p21, and TERC are quantified by qRT-PCR under non-inducible, Inducible and reverse inducible FXR1 silencing conditions in UMSCC74B cells. (B) Immunoblot analysis of protein levels of UMSCC74B cells as described above.
Nallasivam Palanisamy (265021) +7 more
core +1 more source
The stability of miR301a-3p is FXR1 dependent.
, 2020 (A) qRT-PCR assay of FXR1 knockdown UMSCC74B cells showing significant down- and up-regulation of FXR1 and p21, respectively, compared to control. AGO2 did not show any change after the FXR1 knockdown. Both ACTIN and RPS18 served as endogenous controls. (
Mrinmoyee Majumder (3110004) +1 more
core +1 more source
FXR1, an autosomal homolog of the fragile X mental retardation gene. [PDF]
The EMBO Journal, 1995 Fragile X mental retardation syndrome, the most common cause of hereditary mental retardation, is directly associated with the FMR1 gene at Xq27.3. FMR1 encodes an RNA binding protein and the syndrome results from lack of expression of FMR1 or expression of a mutant protein that is impaired in RNA binding.
M C, Siomi +5 more
openaire +2 more sources
Andrology, EarlyView.ABSTRACT Background Sperm cryopreservation causes cryodamage, but the roles of posttranslational modifications (PTMs) and stress granules (SGs) in this process remain unclear. Objectives To investigate the molecular mechanism of cryodamage via the TRIM21–AKAP3 axis, PTMs, and SGs.
Yan Wang +9 more
wiley +1 more source
Image_3_Molecular and Immunohistochemical Expression of LTA4H and FXR1 in Canine Oral Melanoma.tif
, 2021 Oral melanoma is a common canine tumor whose prognosis is considered ominous, but poorly predicted by histology alone. In the present study the gene and protein expression of Leukotriene A4 hydrolase (LTA4H) and Fragile-X-mental retardation-related ...
Maria Longeri (32277) +8 more
core +1 more source