Results 21 to 30 of about 2,120 (152)

The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions [PDF]

EMBO Reports
Viruses interact with numerous host factors to facilitate viral replication and to dampen antiviral defense mechanisms. We currently have a limited mechanistic understanding of how SARS-CoV-2 binds host factors and the functional role of these ...
Dimitriya H Garvanska, R Elias Alvarado, Filip Oskar Mundt, Richard Lindqvist, Josephine Kerzel Duel, Fabian Coscia, Emma Nilsson, Kumari Lokugamage, Bryan A Johnson, Jessica A Plante, Dorothea R Morris, Michelle N Vu, Leah K Estes, Alyssa M McLeland, Jordyn Walker, Patricia A Crocquet-Valdes, Blanca Lopez Mendez, Kenneth S Plante, David H Walker, Melanie Bianca Weisser, Anna K Överby, Matthias Mann, Vineet D Menachery, Jakob Nilsson   +23 more
doaj   +2 more sources

FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms

Cell Reports, 2023
Summary: Appropriate cytoskeletal organization is essential for vascular smooth muscle cell (VSMC) conditions such as hypertension. This study identifies FXR1 as a key protein linking cytoskeletal dynamics with mRNA stability.
Amanda St. Paul, Cali Corbett, Amanda Peluzzo, Sheri Kelemen, Rachael Okune, Dale S. Haines, Kyle Preston, Satoru Eguchi, Michael V. Autieri   +8 more
doaj   +1 more source

The FXR1 network acts as a signaling scaffold for actomyosin remodeling. [PDF]

Cell, 2023
Summary It is currently not known whether mRNAs fulfill structural roles in the cytoplasm. Here, we report the FXR1 network, an mRNA-protein (mRNP) network present throughout the cytoplasm, formed by FXR1-mediated packaging of exceptionally long mRNAs.
Chen X, Fansler MM, Janjoš U, Ule J, Mayr C.   +4 more
europepmc   +5 more sources

RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC. [PDF]

PLoS Genetics, 2016
RNA-binding proteins (RBP) regulate numerous aspects of co- and post-transcriptional gene expression in cancer cells. Here, we demonstrate that RBP, fragile X-related protein 1 (FXR1), plays an essential role in cellular senescence by utilizing mRNA ...
Mrinmoyee Majumder, Reniqua House, Nallasivam Palanisamy, Shuo Qie, Terrence A Day, David Neskey, J Alan Diehl, Viswanathan Palanisamy   +7 more
doaj   +1 more source

FXR1 can bind with the CFIm25/CFIm68 complex and promote the progression of urothelial carcinoma of the bladder by stabilizing TRAF1 mRNA

Cell Death and Disease, 2022
RNA-binding proteins (RBPs) are key regulators of gene expression. RBP dysregulation is reported to play essential roles in tumorigenesis. However, the role of RBPs in urothelial carcinoma of the bladder (UCB) is only starting to be unveiled.
Minhua Deng, Ning Wang, Zhiyong Li, Rixin Chen, Jinling Duan, Yulu Peng, Zeshen Wu, Zhiling Zhang, Lijuan Jiang, Xianchong Zheng, Dan Xie, Wensu Wei, Zhuowei Liu, Fangjian Zhou   +13 more
doaj   +1 more source

Immunohistochemical Expression of FXR1 in Canine Normal Tissues and Melanomas [PDF]

Journal of Histochemistry & Cytochemistry, 2018
Fragile X mental retardation-related protein 1 (FXR1) is a cytoplasmic RNA-binding protein highly conserved among vertebrates. It has been studied for its role in muscle development, inflammation, and tumorigenesis, being related, for example, to metastasizing behavior in human and canine uveal melanoma.
Laura Nordio, Andreia T. Marques, Cristina Lecchi, Alberto M. Luciano, Damiano Stefanello, Chiara Giudice   +5 more
openaire   +2 more sources

Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. [PDF]

PLoS ONE, 2013
We previously identified Fragile X-related protein 1 (FXR1) as an RNA-binding protein involved in the post-transcriptional control of TNF and other cytokines in macrophages. Macrophages derived from FXR1-KO mice overexpress several inflammatory cytokines
Claude Lachance, Gabriella Wojewodka, Tom A A Skinner, Claudine Guilbault, Juan B De Sanctis, Danuta Radzioch   +5 more
doaj   +1 more source

RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer.

PLoS Genetics, 2020
RNA-binding proteins (RBPs) associate with the primary, precursor, and mature microRNAs, which in turn control post-transcriptional gene regulation.
Mrinmoyee Majumder, Viswanathan Palanisamy   +1 more
doaj   +1 more source

Evidence of an interaction between FXR1 and GSK3β polymorphisms on levels of Negative Symptoms of Schizophrenia and their response to antipsychotics

European Psychiatry, 2021
Background Genome-Wide Association Studies (GWASs) have identified several genes associated with Schizophrenia (SCZ) and exponentially increased knowledge on the genetic basis of the disease.
Antonio Rampino, Silvia Torretta, Barbara Gelao, Federica Veneziani, Matteo Iacoviello, Aleksandra Marakhovskaya, Rita Masellis, Ileana Andriola, Leonardo Sportelli, Giulio Pergola, Alessandra Minelli, Chiara Magri, Massimo Gennarelli, Antonio Vita, Jean Martin Beaulieu, Alessandro Bertolino, Giuseppe Blasi   +16 more
doaj   +1 more source

Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1

Cell Adhesion & Migration, 2021
LncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, ENST00000508435, which could be remarkably up-regulated in breast cancer cells and tissues.
Luying Li, Youping Jin, Xue Wang, Li Wang, Yangbai Sun, Yihong Luo, Xiaojian Ni, Qi Lu, Wenbo Wei, Xiuling Zhi, Jerry Yu, Wei Zhu, Ping Zhou   +12 more
doaj   +1 more source