Results 21 to 30 of about 2,644 (175)

The Role of FXR1 in Vascular Smooth Muscle Cytoskeletal Dynamics

, 2023
Appropriate cytoskeletal organization and protein-protein interactions are essential for vascular smooth muscle cell (VSMC) physiological processes relevant to hypertensive conditions. Proteins that link actin dynamics and post-transcriptional mRNA metabolism potentially have a high impact on VSMC pathophysiological processes.
St. Paul, Amanda, 0000-0002-9778-8652
openaire   +2 more sources

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma

Nature Communications, 2017
Fbxo4 tumour suppressor is part of a SCF E3 ligase which has two known substrates. Here, the authors identify Fxr1 as a substrate of SCFFbxo4 and identify an inherent regulatory feedback loop in head and neck squamous cell carcinoma that results in the ...
Shuo Qie, Mrinmoyee Majumder, Katarzyna Mackiewicz, Breege V. Howley, Yuri K. Peterson, Philip H. Howe, Viswanathan Palanisamy, J. Alan Diehl   +7 more
doaj   +2 more sources

The Spatial‐Temporal Alternative Splicing Profile Reveals the Functional Diversity of FXR1 Isoforms in Myogenesis [PDF]

Advanced Science
Alternative splicing (AS) is a fundamental mechanism contributing to proteome diversity, yet its comprehensive landscape and regulatory dynamics during skeletal muscle development remain largely unexplored. Here, the temporal AS profiles are investigated
Wei Wang, Xinhao Fan, Weiwei Liu, Yuxin Huang, Shuhong Zhao, Yalan Yang, Zhonglin Tang   +6 more
doaj   +2 more sources

Thalidomide mitigates Crohn's disease colitis by modulating gut microbiota, metabolites, and regulatory T cell immunity [PDF]

Journal of Pharmaceutical Analysis
Thalidomide (THA) is renowned for its potent anti-inflammatory properties. This study aimed to elucidate its underlying mechanisms in the context of Crohn's disease (CD) development.
Chao-Tao Tang, Yonghui Wu, Qing Tao, Chun-Yan Zeng, You-Xiang Chen   +4 more
doaj   +2 more sources

CircZMYM2 plays a pivotal role in osteosarcoma by regulating the translation of NACA and ARPC1B [PDF]

Heliyon
Osteosarcoma (OS) is a primary malignant bone tumor in children and young adults because of its intertumoral heterogeneity and absence of molecular targets. This study aimed to elucidate the role of circular RNA in the pathogenesis of OS.
Fei Li, Jiaqing Wei, Xiaoxuan Ren, Yawei Hao, Shuaishuai Tian, Lizhi Li   +5 more
doaj   +2 more sources

The KIF6-RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly. [PDF]

Adv Sci (Weinh)
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Xie C, Yi S, Lin X, Zhang S, Wang W, Yuan S, Meng L, Li Y, Tan C, Wei C, Yu Y, Liang Y, Zhang H, Hu L, Lu G, He W, Zhang Q, Du J, Lin G, Tu C, Tan YQ.   +20 more
europepmc   +2 more sources

FXR1-Directed Alternative Splicing of MK5 Drives Hepatocellular Carcinoma Progression by Activating GSK3β Signaling. [PDF]

Cancer Sci
The RNA‐binding protein FXR1 promotes hepatocellular carcinoma (HCC) progression by driving alternative splicing of MK5 to generate an oncogenic isoform, MK5‐L, which activates the Wnt/β‐catenin pathway. Targeting FXR1 with an antisense oligonucleotide suppresses tumor growth in vivo, revealing a promising therapeutic strategy for HCC.
Li Y, Xiang J, Cheng B, Li C, Wang K, Tang N, Huang L.   +6 more
europepmc   +2 more sources

Targeting KIFC1 Promotes Senescence in Soft Tissue Sarcoma via FXR1‐Dependent Regulation of MAD2L1 mRNA Stability [PDF]

Advanced Science
Patients diagnosed with soft tissue sarcoma (STS) often present at intermediate to advanced stages, with inherently limited therapeutic options available. There is an urgent need to identify novel therapeutic targets. In this study, by screening STS data
Xiu‐Xia Lu, Yi Que, Jing Yang, Li‐Yuan Le, Qi‐Yan Cai, Bu‐Shu Xu, Dong‐Chun Hong, Yao Liang, Xing Zhang   +8 more
doaj   +2 more sources

BOLL-Containing Aggregates Mediate the Translational Regulation During Human Oogenesis. [PDF]

Cell Prolif
This work elucidates that BOLL‐containing aggregate‐mediated translational control is essential for human oogenesis. These aggregates recruit PABPC1 and FXR1 to activate the translation of U‐rich mRNAs encoding cell cycle proteins, thereby ensuring successful meiotic progression.
Li Y, Mao L, Liang B, Xie L, Xiang W, Kee K.   +5 more
europepmc   +2 more sources

FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms

Cell Reports, 2023
Summary: Appropriate cytoskeletal organization is essential for vascular smooth muscle cell (VSMC) conditions such as hypertension. This study identifies FXR1 as a key protein linking cytoskeletal dynamics with mRNA stability.
Amanda St. Paul, Cali Corbett, Amanda Peluzzo, Sheri Kelemen, Rachael Okune, Dale S. Haines, Kyle Preston, Satoru Eguchi, Michael V. Autieri   +8 more
doaj   +1 more source