Results 21 to 30 of about 2,417 (183)

The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications [PDF]

Cell Death and Disease
RNA-binding proteins (RBPs) modulate the expression level of several target RNAs (such as mRNAs) post-transcriptionally through interactions with unique binding sites in the 3′-untranslated region.
Faiz Ali Khan, Na Fang, Weijuan Zhang, Shaoping Ji   +3 more
doaj   +2 more sources

FXR1-related congenital myopathy: expansion of the clinical and genetic spectrum

Journal of Medical Genetics, 2022
BACKGROUND: Bi-allelic pathogenic variants in FXR1 have recently been associated with two congenital myopathy phenotypes: a severe form associated with hypotonia, long bone fractures, respiratory insufficiency, and infantile death, and a milder form ...
Laín, Aurelio Hernández, Alikasifoglu, Mehmet, Carsten Bönnemann, Orhan, Diclehan, Sandra Donkervoort, Nowak, Kristen J, Ravenscroft, Gianina, Didem Ardicli, Volker Straub, Duff, Jennifer, Nowak, Kristen, Aurelio Hernández-Laín, Bonnemann, Carsten, Kapetanovic Garcia, Solange, Ardicli, Didem, Cheryl Longman, Haluk Topaloglu, Dimah Saade, Mroczek, Magdalena, Farrugia, Maria Elena, Jennifer Duff, Hernandez-Lain, Aurelio, Topaloglu, Haluk, Garcia, Solange Kapetanovic, Bönnemann, Carsten G, Longman, Cheryl, Sabine Specht, Saade, Dimah, Grace Yoon, Kristen Nowak, Gianina Ravenscroft, Donkervoort, Sandra, Magdalena Mroczek, Solange Kapetanovic Garcia, Straub, Volker, Maria Elena Farrugia, Diclehan Orhan, Katherine Chao, Zaheer Valivullah, Mehmet Alikasifoglu, Specht, Sabine, Valivullah, Zaheer, Chao, Katherine R, Yoon, Grace, Chao, Katherine   +44 more
core   +4 more sources

Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1

Circulation, 2018
Background: Gap junction remodeling is well established as a consistent feature of human heart disease involving spontaneous ventricular arrhythmia.
Miensheng Chu, Ikeotunye Royal Chinyere, Elizabeth B Juneman   +2 more
exaly   +2 more sources

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma

Nature Communications, 2017
Fbxo4 tumour suppressor is part of a SCF E3 ligase which has two known substrates. Here, the authors identify Fxr1 as a substrate of SCFFbxo4 and identify an inherent regulatory feedback loop in head and neck squamous cell carcinoma that results in the ...
Shuo Qie, Mrinmoyee Majumder, Katarzyna Mackiewicz, Breege V. Howley, Yuri K. Peterson, Philip H. Howe, Viswanathan Palanisamy, J. Alan Diehl   +7 more
doaj   +2 more sources

The Spatial‐Temporal Alternative Splicing Profile Reveals the Functional Diversity of FXR1 Isoforms in Myogenesis [PDF]

Advanced Science
Alternative splicing (AS) is a fundamental mechanism contributing to proteome diversity, yet its comprehensive landscape and regulatory dynamics during skeletal muscle development remain largely unexplored. Here, the temporal AS profiles are investigated
Wei Wang, Xinhao Fan, Weiwei Liu, Yuxin Huang, Shuhong Zhao, Yalan Yang, Zhonglin Tang   +6 more
doaj   +2 more sources

Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission

Frontiers in Molecular Neuroscience, 2018
Genetic variants of the fragile X mental retardation syndrome-related protein 1 (FXR1) have been associated to mood regulation, schizophrenia, and bipolar disorders.
Jivan Khlghatyan, Jivan Khlghatyan, Alesya Evstratova, Simon Chamberland, Aleksandra Marakhovskaia, Arash Bahremand, Katalin Toth, Jean-Martin Beaulieu, Jean-Martin Beaulieu   +8 more
doaj   +2 more sources

Thalidomide mitigates Crohn's disease colitis by modulating gut microbiota, metabolites, and regulatory T cell immunity [PDF]

Journal of Pharmaceutical Analysis
Thalidomide (THA) is renowned for its potent anti-inflammatory properties. This study aimed to elucidate its underlying mechanisms in the context of Crohn's disease (CD) development.
Chao-Tao Tang, Yonghui Wu, Qing Tao, Chun-Yan Zeng, You-Xiang Chen   +4 more
doaj   +2 more sources

CircZMYM2 plays a pivotal role in osteosarcoma by regulating the translation of NACA and ARPC1B [PDF]

Heliyon
Osteosarcoma (OS) is a primary malignant bone tumor in children and young adults because of its intertumoral heterogeneity and absence of molecular targets. This study aimed to elucidate the role of circular RNA in the pathogenesis of OS.
Fei Li, Jiaqing Wei, Xiaoxuan Ren, Yawei Hao, Shuaishuai Tian, Lizhi Li   +5 more
doaj   +2 more sources

Regulation of monocyte induced cell migration by the RNA binding protein, FXR1 [PDF]

Cell Cycle, 2016
FXR1 belongs to a family of RNA-binding proteins that play critical roles in post-transcriptional regulation of gene expression in immunity, development and cancer. FXR1 is associated with regulation of specific mRNAs in myocytes and macrophages.
S. Kollu (2808256), S. Lee (537439), S.S. Truesdell (2808250), M. Al-Salah (2808259), O. Le Tonqueze (2808253), S. Vasudevan (2205166)   +5 more
core   +3 more sources

FXR1 Drives Oncogenic Transformation Through Regulation of Translation

, 2013
Cells use translation to respond quickly and robustly to many different situations. Eukaryotic translation is not only controlled globally but can be as specific as a single mRNA transcript allowing a massive response or fine tuning by the cell.
Lewis, Cory Lee
core   +3 more sources