Molecular and Immunohistochemical Expression of LTA4H and FXR1 in Canine Oral Melanoma [PDF]
Frontiers in Veterinary Science, 2021 Oral melanoma is a common canine tumor whose prognosis is considered ominous, but poorly predicted by histology alone. In the present study the gene and protein expression of Leukotriene A4 hydrolase (LTA4H) and Fragile-X-mental retardation-related ...
Laura Nordio +8 more
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An in-depth review of the function of RNA-binding protein FXR1 in neurodevelopment [PDF]
Cell and Tissue ResearchFMR1 autosomal homolog 1 (FXR1) is an RNA-binding protein that belongs to the Fragile X-related protein (FXR) family. FXR1 is critical for development, as its loss of function is intolerant in humans and results in neonatal death in mice. Although FXR1 is expressed widely including the brain, functional studies on FXR1 have been mostly performed in ...
Méndez-Albelo NM +3 more
exaly +4 more sources
Comparing loss of individual fragile X proteins suggests strong links to cellular senescence and aging [PDF]
Cellular and Molecular Life SciencesMembers of the fragile X protein (FXP) family (FMR1, FXR1 and FXR2) are differentially expressed in most types of cancer and major neurodegenerative diseases.
Sonja Menge +9 more
doaj +2 more sources
FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG
Journal of Experimental & Clinical Cancer Research, 2019 Background Accumulating evidence has highlighted the potential role of RNA binding proteins (RBPs) in the biological behaviors of glioblastoma cells. Herein, the expression and function of RNA binding proteins FXR1 were investigated in human glioma cells.
Shuo Cao +12 more
doaj +3 more sources
The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications [PDF]
Cell Death and DiseaseRNA-binding proteins (RBPs) modulate the expression level of several target RNAs (such as mRNAs) post-transcriptionally through interactions with unique binding sites in the 3′-untranslated region.
Faiz Ali Khan +3 more
doaj +2 more sources
The Spatial‐Temporal Alternative Splicing Profile Reveals the Functional Diversity of FXR1 Isoforms in Myogenesis [PDF]
Advanced ScienceAlternative splicing (AS) is a fundamental mechanism contributing to proteome diversity, yet its comprehensive landscape and regulatory dynamics during skeletal muscle development remain largely unexplored. Here, the temporal AS profiles are investigated
Wei Wang +6 more
doaj +2 more sources
PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility
Advanced ScienceProteasome experiences sophisticated dynamics in types, quantities, and activities during spermiogenesis. However, the physiological importance of proteasomal degradation in mammalian spermiogenesis remains largely unknown. Here, we report that the PSMA8‐
Huiwen Cao +7 more
doaj +2 more sources
Thalidomide mitigates Crohn's disease colitis by modulating gut microbiota, metabolites, and regulatory T cell immunity [PDF]
Journal of Pharmaceutical AnalysisThalidomide (THA) is renowned for its potent anti-inflammatory properties. This study aimed to elucidate its underlying mechanisms in the context of Crohn's disease (CD) development.
Chao-Tao Tang +4 more
doaj +2 more sources
CircZMYM2 plays a pivotal role in osteosarcoma by regulating the translation of NACA and ARPC1B [PDF]
HeliyonOsteosarcoma (OS) is a primary malignant bone tumor in children and young adults because of its intertumoral heterogeneity and absence of molecular targets. This study aimed to elucidate the role of circular RNA in the pathogenesis of OS.
Fei Li +5 more
doaj +2 more sources
Targeting KIFC1 Promotes Senescence in Soft Tissue Sarcoma via FXR1‐Dependent Regulation of MAD2L1 mRNA Stability [PDF]
Advanced SciencePatients diagnosed with soft tissue sarcoma (STS) often present at intermediate to advanced stages, with inherently limited therapeutic options available. There is an urgent need to identify novel therapeutic targets. In this study, by screening STS data
Xiu‐Xia Lu +8 more
doaj +2 more sources