Results 11 to 20 of about 2,644 (175)

The FXR1 Network Acts as a Signaling Scaffold for Actomyosin Remodeling [PDF]

Cell, 2023
Summary It is currently not known whether mRNAs fulfill structural roles in the cytoplasm. Here, we report the FXR1 network, an mRNA-protein (mRNP) network present throughout the cytoplasm, formed by FXR1-mediated packaging of exceptionally long mRNAs.
Christine Mayr
exaly   +8 more sources

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility [PDF]

Advanced Science
Proteasome experiences sophisticated dynamics in types, quantities, and activities during spermiogenesis. However, the physiological importance of proteasomal degradation in mammalian spermiogenesis remains largely unknown. Here, we report that the PSMA8‐
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
doaj   +3 more sources

FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG

Journal of Experimental & Clinical Cancer Research, 2019
Background Accumulating evidence has highlighted the potential role of RNA binding proteins (RBPs) in the biological behaviors of glioblastoma cells. Herein, the expression and function of RNA binding proteins FXR1 were investigated in human glioma cells.
Shuo Cao, Jian Zheng, Xiaobai Liu, Yunhui Liu, Xuelei Ruan, Jun Ma, Libo Liu, Di Wang, Chunqing Yang, Heng Cai, Zhen Li, Ziyi Feng, Yixue Xue   +12 more
doaj   +4 more sources

RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC. [PDF]

PLoS Genetics, 2016
RNA-binding proteins (RBP) regulate numerous aspects of co- and post-transcriptional gene expression in cancer cells. Here, we demonstrate that RBP, fragile X-related protein 1 (FXR1), plays an essential role in cellular senescence by utilizing mRNA ...
Mrinmoyee Majumder, Reniqua House, Nallasivam Palanisamy, Shuo Qie, Terrence A Day, David Neskey, J Alan Diehl, Viswanathan Palanisamy   +7 more
doaj   +5 more sources

FXR1-related congenital myopathy: expansion of the clinical and genetic spectrum [PDF]

Journal of Medical Genetics, 2022
Background Biallelic pathogenic variants in FXR1 have recently been associated with two congenital myopathy phenotypes: a severe form associated with hypotonia, long bone fractures, respiratory insufficiency and infantile death, and a milder form characterised by proximal muscle weakness with survival into adulthood.
Magdalena Mroczek, Cheryl Longman, Maria Elena Farrugia, Solange Kapetanovic Garcia, Didem Ardicli, Haluk Topaloglu, Aurelio Hernández-Laín, Diclehan Orhan, Mehmet Alikasifoglu, Jennifer Duff, Sabine Specht, Kristen Nowak, Gianina Ravenscroft, Katherine Chao, Zaheer Valivullah, Sandra Donkervoort, Dimah Saade, Carsten Bönnemann, Volker Straub, Grace Yoon   +19 more
openaire   +5 more sources

Molecular and Immunohistochemical Expression of LTA4H and FXR1 in Canine Oral Melanoma [PDF]

Frontiers in Veterinary Science, 2021
Oral melanoma is a common canine tumor whose prognosis is considered ominous, but poorly predicted by histology alone. In the present study the gene and protein expression of Leukotriene A4 hydrolase (LTA4H) and Fragile-X-mental retardation-related ...
Laura Nordio, Chiara Bazzocchi, Francesca Genova, Valentina Serra, Maria Longeri, Giovanni Franzo, Marco Rondena, Damiano Stefanello, Chiara Giudice   +8 more
doaj   +4 more sources

Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission

Frontiers in Molecular Neuroscience, 2018
Genetic variants of the fragile X mental retardation syndrome-related protein 1 (FXR1) have been associated to mood regulation, schizophrenia, and bipolar disorders.
Jivan Khlghatyan, Jivan Khlghatyan, Alesya Evstratova, Simon Chamberland, Aleksandra Marakhovskaia, Arash Bahremand, Katalin Toth, Jean-Martin Beaulieu, Jean-Martin Beaulieu   +8 more
doaj   +2 more sources

An In-Depth Review of the Function of RNA-Binding Protein FXR1 in Neurodevelopment [PDF]

Cell and Tissue Research
FMR1 autosomal homolog 1 (FXR1) is an RNA-binding protein that belongs to the Fragile X-related protein (FXR) family. FXR1 is critical for development, as its loss of function is intolerant in humans and results in neonatal death in mice. Although FXR1 is expressed widely including the brain, functional studies on FXR1 have been mostly performed in ...
Méndez-Albelo NM, Sandoval SO, Xu Z, Zhao X.   +3 more
exaly   +4 more sources

Circ_0000079 Decoys the RNA-Binding Protein FXR1 to Interrupt Formation of the FXR1/PRCKI Complex and Decline Their Mediated Cell Invasion and Drug Resistance in NSCLC [PDF]

Cell Transplantation, 2020
Nonsmall cell lung cancer (NSCLC) has gradually become one of the deadliest threats to human health and life worldwide. Although reports have shown that circular RNAs (circRNAs) are associated with progression and metastasis of NSCLC, the biological ...
Chen Chen, Min Zhang, Yan Zhang
doaj   +3 more sources

FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin–proteasome system

Scientific Reports, 2023
The ubiquitin–proteasome system (UPS) is a proteolytic pathway that is essential for life maintenance and vital functions, and its disruption causes serious impairments, e.g., disease development. Thus, the UPS is properly regulated.
Hideo Shimizu, Hirohiko Hohjoh
doaj   +2 more sources