The FXR1 network acts as a signaling scaffold for actomyosin remodeling [PDF]
Cell, 2023 It is currently not known whether mRNAs fulfill structural roles in the cytoplasm. Here, we report the fragile X-related protein 1 (FXR1) network, an mRNA-protein (mRNP) network present throughout the cytoplasm, formed by FXR1-mediated packaging of ...
Fansler, Mervin M. +5 more
core +6 more sources
Amyloid Properties of the FXR1 Protein Are Conserved in Evolution of Vertebrates
International Journal of Molecular Sciences, 2022 Functional amyloids are fibrillary proteins with a cross-β structure that play a structural or regulatory role in pro- and eukaryotes. Previously, we have demonstrated that the RNA-binding FXR1 protein functions in an amyloid form in the rat brain.
Alexey P Galkin, Galkin Alexey P
exaly +4 more sources
Molecular and Immunohistochemical Expression of LTA4H and FXR1 in Canine Oral Melanoma [PDF]
Frontiers in Veterinary Science, 2021 Oral melanoma is a common canine tumor whose prognosis is considered ominous, but poorly predicted by histology alone. In the present study the gene and protein expression of Leukotriene A4 hydrolase (LTA4H) and Fragile-X-mental retardation-related ...
Laura Nordio +8 more
doaj +4 more sources
An in-depth review of the function of RNA-binding protein FXR1 in neurodevelopment [PDF]
Cell and Tissue ResearchFMR1 autosomal homolog 1 (FXR1) is an RNA-binding protein that belongs to the Fragile X-related protein (FXR) family. FXR1 is critical for development, as its loss of function is intolerant in humans and results in neonatal death in mice. Although FXR1 is expressed widely including the brain, functional studies on FXR1 have been mostly performed in ...
Xinyu Zhao
exaly +4 more sources
Circ_0000079 Decoys the RNA-Binding Protein FXR1 to Interrupt Formation of the FXR1/PRCKI Complex and Decline Their Mediated Cell Invasion and Drug Resistance in NSCLC [PDF]
Cell Transplantation, 2020 Nonsmall cell lung cancer (NSCLC) has gradually become one of the deadliest threats to human health and life worldwide. Although reports have shown that circular RNAs (circRNAs) are associated with progression and metastasis of NSCLC, the biological ...
Chen Chen, Min Zhang, Yan Zhang
doaj +3 more sources
Comparing loss of individual fragile X proteins suggests strong links to cellular senescence and aging [PDF]
Cellular and Molecular Life SciencesMembers of the fragile X protein (FXP) family (FMR1, FXR1 and FXR2) are differentially expressed in most types of cancer and major neurodegenerative diseases.
Sonja Menge +9 more
doaj +2 more sources
The Role of FXR1 in Vascular Smooth Muscle Cytoskeletal Dynamics
, 2023 Appropriate cytoskeletal organization and protein-protein interactions are essential for vascular smooth muscle cell (VSMC) physiological processes relevant to hypertensive conditions.
St. Paul, Amanda, 0000-0002-9778-8652
core +2 more sources
RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC. [PDF]
PLoS Genetics, 2016 RNA-binding proteins (RBP) regulate numerous aspects of co- and post-transcriptional gene expression in cancer cells. Here, we demonstrate that RBP, fragile X-related protein 1 (FXR1), plays an essential role in cellular senescence by utilizing mRNA ...
Mrinmoyee Majumder +7 more
doaj +3 more sources
RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer.
PLoS Genetics, 2020 RNA-binding proteins (RBPs) associate with the primary, precursor, and mature microRNAs, which in turn control post-transcriptional gene regulation.
Mrinmoyee Majumder +1 more
doaj +2 more sources
Fragile X-Related Protein FXR1 Controls Human Adenovirus Capsid mRNA Metabolism
Journal of Virology, 2023 Human adenoviruses (HAdVs) are widespread pathogens causing a variety of diseases. A well-controlled expression of virus capsid mRNAs originating from the major late transcription unit (MLTU) is essential for forming the infectious virus progeny. However,
Mahmoud Darweesh +2 more
exaly +2 more sources