Results 71 to 80 of about 1,075 (130)

Understanding GEMIN5 Interactions: From Structural and Functional Insights to Selective Translation

WIREs RNA, Volume 16, Issue 2, March/April 2025.
GEMIN5 structural domains. Overview of GEMIN5's role in snRNP assembly and translation regulatory events. ABSTRACT GEMIN5 is a predominantly cytoplasmic protein, initially identified as a member of the survival of motor neurons (SMN) complex. In addition, this abundant protein modulates diverse aspects of RNA‐dependent processes, executing its ...
Encarnacion Martinez‐Salas, Salvador Abellan, Rosario Francisco‐Velilla   +2 more
wiley   +1 more source

Genetic alteration of SLCO1B3 defines constitutional indocyanine green excretory defect in patients who underwent hepatectomy

Hepatology Research, Volume 55, Issue 1, Page 106-114, January 2025.
The homozygous SLCO1B3 gene alteration provided remarkably high indocyanine green retention rate regardless of the normal clinical and pathological findings, while its heterozygous alteration had no effect. The homozygous SLCO1B3 gene alteration may define constitutional indocyanine green excretory defects. Abstract Aim Constitutional indocyanine green
Meguri Tanimoto, Yujiro Nishioka, Yoshinori Inagaki, Takashi Kokudo, Takeaki Ishizawa, Junichi Arita, Nobuhisa Akamatsu, Junichi Kaneko, Kiyoshi Hasegawa   +8 more
wiley   +1 more source

Single and Multiple Doses of Seladelpar Decrease Diurnal Markers of Bile Acid Synthesis in Mice

PPAR Research, Volume 2025, Issue 1, 2025.
Peroxisome proliferator–activated receptors (PPARs) modulate bile metabolism and are important therapeutic options in cholestatic diseases. This study was aimed at understanding the effects of single and multiple doses of seladelpar, a PPARδ (peroxisome proliferator–activated receptor delta) agonist, on plasma C4 (a freely diffusible metabolite ...
Edward E. Cable, Jeffrey W. Stebbins, Jeff D. Johnson, Yun-Jung Choi, Jiangao Song, Sole Gatto, Matthew Onorato, Charles A. McWherter, Stéphane Mandard   +8 more
wiley   +1 more source

Animal characteristics under chow-fed conditions.

, 2014
Animal characteristics of chow-fed FXR knock-out mice injected with PBS or stably transduced with hepatic-specific scAAV-FXR2 or scAAV-FXR4 were compared to chow-fed wild-type (WT) mice. Values are presented as median (range) (n = 5–6 animals per group).*
Marije Boesjes (674860), Vincent W. Bloks (674861), Theo H. van Dijk (120087), Henk Wolters (674864), Jurre Hageman (674862), Trijnie Bos (674863), Rick Havinga (197532), Albert K. Groen (128588), Johan W. Jonker (674865), Folkert Kuipers (120092)   +9 more
core   +1 more source

Hunting Stability Enhancement of a Train Bogie Employing Inerter‐Based Suspension Mechanism

Shock and Vibration, Volume 2025, Issue 1, 2025.
The bogie hunting instability may occur in the train traveling process, which has an important effect on the train operation safety and passenger ride quality. Three inerter‐based suspension mechanisms are designed and applied in the secondary lateral suspension of the train bogie to improve bogie hunting stability. The M1 and M2 configurations consist
Yong Wang, Chenyang Hong, Haodong Meng, Zhipeng Zhao   +3 more
wiley   +1 more source

Primate‐Specific DAZ Regulates Translation of Cell Proliferation‐Related mRNAs and is Essential for Maintenance of Spermatogonia

Advanced Science, Volume 11, Issue 29, August 7, 2024.
It is revealed that DAZ interacts with PABPC1 via the DAZ repeat domain to regulate the translation of target transcripts involved in cell proliferation and cell cycle phase transition (such as c‐KIT and SMC2) in the human testis. Loss of DAZ (Y chromosome AZFc deletion) may result in defective proliferation of c‐KIT‐positive spermatogonia and ...
Ningjing Ou, Yuci Wang, Shuai Xu, Jiaqiang Luo, Chenwang Zhang, Yangyi Zhang, Xiaoyan Shi, Minggang Xiong, Liangyu Zhao, Zhiyong Ji, Yuxiang Zhang, Jingpeng Zhao, Haowei Bai, Ruhui Tian, Peng Li, Erlei Zhi, Yuhua Huang, Wei Chen, Ruiqi Wang, Yuxuan Jin, Dian Wang, Zheng Li, Hao Chen, Chencheng Yao   +23 more
wiley   +1 more source

Liquid–liquid phase separation in diseases

MedComm, Volume 5, Issue 7, July 2024.
Liquid–liquid phase separation (LLPS) as a rising molecular entity in the cytoplasm regulates diseases progression via a variety of ways. For example, the relationship between LLPS and cancer can be summarized into six aspects: gene fusions/mutations, heterochromatin formation, transcriptional machinery, cellular homeostasis, microenvironment, and RNA ...
Xinyue Zhang, Lin Yuan, Wanlu Zhang, Yi Zhang, Qun Wu, Chunting Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster

, 2017
Fragile-X syndrome is the most common form of inherited mental retardation accompanied by other phenotypes, including macroorchidism. The disorder originates with mutations in the Fmr1 gene coding for the FMRP protein, which, with its paralogs FXR1 and ...
Antonietta Puricella, Valeria Specchia, Simona D’Attis, Maria Bozzetti   +3 more
core   +2 more sources

FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression.

, 2015
In brain, specific RNA-binding proteins (RBPs) associate with localized mRNAs and function as regulators of protein synthesis at synapses exerting an indirect control on neuronal activity.
Fiers, M., Achsel, T., Fiers, M, Smit, A.B., BAGNI, CLAUDIA, Rajan, N., Li, K.W., Bagni, C., de Rubeis, S, Li, K.W.; id_orcid, Li, Kw, Fernandez, E, Smit, Ab, Achsel, T, de Rubeis, S., Rajan, N, Fernandez, E.   +16 more
core   +1 more source

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma

, 2017
The Fbxo4 tumour suppressor is a component of an Skp1-Cul1-F-box E3 ligase for which two substrates are known. Here we show purification of SCFFbxo4 complexes results in the identification of fragile X protein family (FMRP, Fxr1 and Fxr2) as binding ...
Shuo Qie, Viswanathan Palanisamy, Mrinmoyee Majumder, Katarzyna Mackiewicz, Breege V. Howley, Yuri K. Peterson, J. Alan Diehl, Philip H. Howe   +7 more
core   +1 more source