Results 71 to 80 of about 1,143 (122)

Liquid–liquid phase separation in diseases

MedComm, Volume 5, Issue 7, July 2024.
Liquid–liquid phase separation (LLPS) as a rising molecular entity in the cytoplasm regulates diseases progression via a variety of ways. For example, the relationship between LLPS and cancer can be summarized into six aspects: gene fusions/mutations, heterochromatin formation, transcriptional machinery, cellular homeostasis, microenvironment, and RNA ...
Xinyue Zhang, Lin Yuan, Wanlu Zhang, Yi Zhang, Qun Wu, Chunting Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

FXR2P exerts a positive translational control and is required for the activity-Dependent Increase of PSD95 expression

, 2015
In brain, specific RNA-binding proteins (RBPs) associate with localized mRNAs and function as regulators of protein synthesis at synapses exerting an indirect control on neuronal activity.
Fiers, M., Achsel, T., Fiers, M, Smit, A.B., BAGNI, CLAUDIA, Rajan, N., Bagni, C., de Rubeis, S, Li, K.W.; id_orcid, Li, Kw, Fernandez, E, Smit, Ab, Achsel, T, de Rubeis, S., Rajan, N, Fernandez, E.   +15 more
core   +1 more source

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma

, 2017
The Fbxo4 tumour suppressor is a component of an Skp1-Cul1-F-box E3 ligase for which two substrates are known. Here we show purification of SCFFbxo4 complexes results in the identification of fragile X protein family (FMRP, Fxr1 and Fxr2) as binding ...
Shuo Qie, Viswanathan Palanisamy, Mrinmoyee Majumder, Katarzyna Mackiewicz, Breege V. Howley, Yuri K. Peterson, J. Alan Diehl, Philip H. Howe   +7 more
core   +1 more source

Reduction in fragile X related 1 protein causes cardiomyopathy and muscular dystrophy in zebrafish

, 2009
Lack of the FMR1 gene product causes fragile X syndrome, the commonest inherited cause of mental impairment. We know little of the roles that fragile X related (FXR) gene family members (FMR1, FXR2 and FXR1) play during embryonic development.
Zondervan - van der Linde, Herma, Chaudhry, B, van 't Padje, S, Mientjes, Edwin; id_orcid, Willemsen, Rob, Oostra, Ben, Severijnen, Lies-anne, Ben A. Oostra, Rob Willemsen, Lies-Anne Severijnen, Herma C. van der Linde, Sandra van't Padje, Bill Chaudhry, Edwin J. Mientjes   +13 more
core   +1 more source

Molecular mechanisms of fragile X syndrome [PDF]

, 2000
Fragile X syndrome is the most common form of inherited mental retardation. Mutations which abolish expression of an X-linked gene, FMR1, result in pathogenesis of the disease.
シオミ, ハルヒコ, Siomi, Mikiko C., Inoue, Shunsuke B., イノウエ, シュンスケ, シオミ, ミキコ, Siomi, Haruhiko   +5 more
core  

Potential miRNA Target Sites in the 3′ UTRs of Selected Genes

, 2013
Nucleotide sequence conservation between the 3′ UTRs of human and the closest mouse or rat orthologous genes is averaged for each block of 40 base pairs (long rectangles; white indicates 0% identical nucleotides, black indicates 100% identical ...
Thomas Tuschl (3155), Anton J Enright (514), Chris Sander (1345), Alexei Aravin (8265), Debora S Marks (3156), Bino John (3153)   +5 more
core   +1 more source

Reduction in fragile X related 1 protein causes cardiomyopathy and muscular dystrophy in zebrafish

Lack of the FMR1 gene product causes fragile X syndrome, the commonest inherited cause of mental impairment. We know little of the roles that fragile X related (FXR) gene family members (FMR1, FXR2 and FXR1) play during embryonic development.
Severijnen L, van der Linde H, Chaudhry B, Oostra B, Mientjes E, Willemsen R, van't Padje S   +6 more
core   +3 more sources

FMRP targets distinct mRNA sequence elements to regulate protein expression

, 2012
Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-orchidism in males and premature ovarian insufficiency in female carriers. FXS is also a prominent monogenic disease associated with autism spectrum disorders (ASDs)
Ohler, U., Thomas Tuschl, Miller, J.B., David L. Corcoran, Nusbaum, J.D., Dewell, S., Neelanjan Mukherjee, Tuschl, T., Mukherjee, N., Munschauer, M., Jason B. Miller, Markus Hafner, Zev Williams, Uwe Ohler, Langlois, C., Jeffrey D. Nusbaum, Hafner, M., Manuel Ascano, Christine Langlois, Bandaru, P., Williams, Z., Scott Dewell, Ascano, M., Corcoran, D.L., Pradeep Bandaru, Mathias Munschauer   +25 more
core   +1 more source

Novel methods for the quantitative determination of RNA folding on a genome-wide scale and in a targeted manner [PDF]

, 2016
The coupling of structure-specific in vivo chemical modification to next-generation sequencing has revolutionized the study of RNA secondary structure in living cells. Nonetheless, current approaches are limited by the detection of structural information
Zubradt, Meghan
core  

The Fragile X Protein Family in Amyotrophic Lateral Sclerosis. [PDF]

Mol Neurobiol, 2023
Mueller S, Decker L, Menge S, Ludolph AC, Freischmidt A.   +4 more
europepmc   +1 more source