Results 41 to 50 of about 1,143 (122)

Comprehensive Analysis of Differentially Expressed Profiles of mRNA N6-Methyladenosine in Colorectal Cancer

Frontiers in Cell and Developmental Biology, 2022
Aim: To comprehensively profile the landscape of the mRNA N6-methyladenosine (m6A) modification in human colorectal cancer (CRC).Methods: Methylated RNA immunoprecipitation sequencing (MeRIP-seq) was explored to compare the difference in mRNA N6 ...
Na Li, Qin Guo, Qiao Zhang, Bai-Jun Chen, Xiao-An Li, Yan Zhou   +5 more
doaj   +1 more source

CircTmeff1 Promotes Muscle Atrophy by Interacting with TDP‐43 and Encoding A Novel TMEFF1‐339aa Protein

Advanced Science, Volume 10, Issue 17, June 13, 2023., 2023
circTmeff1 is elevated in various types of muscle atrophy models. Overexpressing circTmeff1 promotes muscle atrophy, while the knockdown of that rescues the muscle atrophy at both animal and cellular levels. circTmeff1 promotes muscle atrophy by directly interacting with TDP‐43 and encoding a protein TMEFF1‐339aa.
Rui Chen, Tingting Yang, Bing Jin, Wanru Xu, Yuwei Yan, Nathanael Wood, H. Immo Lehmann, Siqi Wang, Xiaolan Zhu, Weilin Yuan, Hongjian Chen, Zhengyu Liu, Guoping Li, T. Scott Bowen, Jin Li, Junjie Xiao   +15 more
wiley   +1 more source

Short-term oral pre-exposure prophylaxis against HIV-1 modulates the transcriptome of foreskin tissue in young men in Africa

Frontiers in Immunology, 2022
Whilst short-term oral pre-exposure prophylaxis (PrEP) with antiretroviral drugs in men who have sex with men has shown protection against HIV-1 infection, the impact of this regimen on the in vivo foreskin transcriptome is unknown. We collected foreskin
Stefan Petkov, Carolina Herrera, Laura Else, Limakatso Lebina, Daniel Opoka, Daniel Opoka, Thabiso B. Seiphetlo, Azure-Dee AP. Pillay, Susan Mugaba, Susan Mugaba, Patricia Namubiru, Patricia Namubiru, Geoffrey Odoch, Geoffrey Odoch, Andrew S. Ssemata, Andrew S. Ssemata, Jennifer Serwanga, Jennifer Serwanga, Pontiano Kaleebu, Pontiano Kaleebu, Emily L. Webb, Saye Khoo, Neil Martinson, Clive M. Gray, Julie Fox, Francesca Chiodi   +25 more
doaj   +1 more source

CircNFIX stimulates the proliferation, invasion, and stemness properties of ovarian cancer cells by enhancing SH3RF3 mRNA stability via binding LIN28B

The Kaohsiung Journal of Medical Sciences, Volume 39, Issue 3, Page 234-243, March 2023., 2023
Abstract We aimed to study the regulatory roles and mechanism of circular nuclear factor IX (circNFIX) in cancer growth and stemness properties of ovarian cancer (OC). CircNFIX and SH3RF3 levels in OC tissues and cells were tested by quantitative real‐time PCR. RNase R treatment quantified circNFIX RNA stability.
Xiu‐Zhang Yu, Bo‐Wen Yang, Meng‐Yin Ao, Yu‐Ke Wu, Hui Ye, Rui‐Yu Wang, Ming‐Rong Xi, Min‐Min Hou   +7 more
wiley   +1 more source

Fragile X-Related Proteins Regulate Mammalian Circadian Behavioral Rhythms [PDF]

, 2008
Fragile X syndrome results from the absence of the fragile X mental retardation 1 (FMR1) gene product (FMRP). FMR1 has two paralogs in vertebrates: fragile X related gene 1 and 2 (FXR1 and FXR2).
Vansteensel, MJ, Ben A. Oostra, Lee, C.C., Johanna H. Meijer, Meijer, JH, Meijer, Johanna H., Albrecht, U, Oostra, Ben A., Mariska J. Vansteensel, Kaasik, K. (Krista), Jud, Corinne, Filippo Tamanini, Kaasik, Krista, Zhang, Jing, Tamanini, F. (Filippo), Zhe Fang, Urs Albrecht, Tamanini, Filippo, Lee, CC, Cheng Chi Lee, Nelson, David L., Nelson, D.L. (David), Kaasik, K, Vansteensel, Mariska J., Oostra, Ben, Fang, Z., Nelson, DL, Fang, Z, Zhang, J. (Jing), Meijer, J.H. (Johanna), Krista Kaasik, Jing Zhang, Vansteensel, M.J. (M. J.), David L. Nelson, Jud, C. (Corinne), Albrecht, U. (Urs), Corinne Jud, Jud, C, Oostra, B.A. (Ben), Lee, Cheng Chi, Fang, Zhe, Albrecht, Urs, Zhang, J   +42 more
core   +1 more source

Fragile X family members have important and non-overlapping functions

Biomolecular Concepts, 2011
The fragile X family of genes encodes a small family of RNA binding proteins including FMRP, FXR1P and FXR2P that were identified in the 1990s. All three members are encoded by 17 exons and show alternative splicing at the 3′ ends of their respective ...
Winograd Claudia, Ceman Stephanie
doaj   +1 more source

A computational map of the human-SARS-CoV-2 protein-RNA interactome predicted at single-nucleotide resolution. [PDF]

NAR Genom Bioinform, 2023
RNA-binding proteins (RBPs) are critical host factors for viral infection, however, large scale experimental investigation of the binding landscape of human RBPs to viral RNAs is costly and further complicated due to sequence variation between viral ...
Horlacher M, Oleshko S, Hu Y, Ghanbari M, Cantini G, Schinke P, Vergara EE, Bittner F, Mueller NS, Ohler U, Moyon L, Marsico A.   +11 more
europepmc   +2 more sources

Kh Domains on Brain Polyribosomes: FMRP and Nova in Translational Regulation [PDF]

, 2007
The regulation of protein synthesis is an important aspect of the control of gene expression in neurons and is thought to contribute to neurologic diseases such as Fragile X mental retardation syndrome.
Fraser, Claire Elizabeth
core   +1 more source

A serum microRNA sequence reveals fragile X protein pathology in amyotrophic lateral sclerosis

, 2021
Knowledge about converging disease mechanisms in the heterogeneous syndrome amyotrophic lateral sclerosis (ALS) is rare, but may lead to therapies effective in most ALS cases.
Böckers, Tobias M., Andersen, Peter M.,, Ludolph, Albert C., Yamoah, A., Ludolph, A., Weis, Joachim, Danzer, Karin M.,, Demestre, M., Freischmidt, Axel, Böckers, Tobias M.,, Aronica, Eleonora,, Goswami, A., Zimyanin, Vitaly L.,, Freischmidt, A., Weis, Joachim,, Tripathi, P., Oefner, Peter J.,, Poser, Ina, Zimyanin, Vitaly L., Brockmann, S., Demestre, Maria,, Holzmann, K., Yamoah, Alfred, Holzmann, Karlheinz,, Hermann, Andreas, Helferich, Anika M.,, Goswami, Anand, Oefner, Peter J., Andersen, P., Zimyanin, V., Reinders, J., Böckers, T., Oefner, P., Ludolph, Albert C.,, Weis, J., Reinders, Jörg,, Tripathi, Priyanka,, Andersen, Peter M., Glaß, H., Tripathi, Priyanka, Holzmann, Karlheinz, Glaß, Hannes, Freischmidt, Axel,, Goswami, Anand,, Danzer, K., Glaß, Hannes,, Hermann, Andreas,, Danzer, Karin M., Weishaupt, Jochen H.,, Poser, Ina,, Demestre, Maria, Limm, K., Aronica, E., Limm, Katharina, Aronica, Eleonora, Brockmann, Sarah J.,, Yamoah, Alfred,, Helferich, A., Weishaupt, Jochen H., Reinders, Jörg, Hermann, A., Weishaupt, J., Limm, Katharina,, Helferich, Anika M., Brockmann, Sarah J., Poser, I., Tobias M Böckers, Axel Freischmidt, Karin M Danzer, Anand Goswami, Hannes Glaß, Eleonora Aronica, Alfred Yamoah, Karlheinz Holzmann, Jörg Reinders, Ina Poser, Maria Demestre, Jochen H Weishaupt, Joachim Weis, Katharina Limm, Andreas Hermann, Priyanka Tripathi, Peter J Oefner, Albert C Ludolph, Sarah J Brockmann, Vitaly L Zimyanin, Peter M Andersen, Anika M Helferich   +87 more
core   +1 more source

Spatial control of nucleoporin condensation by fragile X‐related proteins [PDF]

, 2020
Nucleoporins (Nups) build highly organized nuclear pore complexes (NPCs) at the nuclear envelope (NE). Several Nups assemble into a sieve-like hydrogel within the central channel of the NPCs.
Schmucker, S., Sumara, Izabela, Moine, H., Stephane Schmucker, Kleiss, C., Charlotte Kleiss, Bagni, C., Schwab, Y., Hervé Moine, Ronchi, Paolo, Jmel Boyer, I., Berto, A., Claudia Bagni, Guerard, L., Laura Pacini, Berto, Alessandro, Jerabkova, K., Inès Jmel Boyer, Pacini, Laura, Guerard, Laurent, Jmel Boyer, Inès, Sumara, I., Mandel, J.L., Paolo Ronchi, Moine, Herve, Bagni, Claudia, Agote-Aran, A., Schwab, Yannick, Jean‐Louis Mandel, Sebastien Jacquemont, Agote‐aran, Arantxa, Katerina Jerabkova, Yannick Schwab, Arantxa Agote‐Aran, Laurent Guerard, Jerabkova, Katerina, Boyer, Ines Jmel, Mandel, Jean‐louis, Mandel, Jean-Louis, Agote-Aran, Arantxa, Jacquemont, S., Jacquemont, Sebastien, Ronchi, P., Alessandro Berto, Kleiss, Charlotte, Pacini, L., Izabela Sumara, Schmucker, Stephane, Mandel JL, Ronchi P, Kleiss C, Jacquemont S, Moine H, Schwab Y, Guerard L, Jmel Boyer I, Jerabkova K, Bagni C, Agote-Aran A, Pacini L, Schmucker S, Sumara I, Berto A   +62 more
core   +1 more source