Comparative Behavioral Phenotypes of Fmr1 KO, Fxr2 Het, and Fmr1 KO/Fxr2 Het Mice [PDF]
Brain Sciences, 2019 Fragile X syndrome (FXS) is caused by silencing of the FMR1 gene leading to loss of the protein product fragile X mental retardation protein (FMRP). FXS is the most common monogenic cause of intellectual disability. There are two known mammalian paralogs
Rachel Michelle Sare +2 more
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Clinical Significance of Fragile X Syndrome 2 (FXR2) in Breast Cancer [PDF]
GenesBackground: The fragile X protein family comprises three members: the fragile X syndrome protein (FMRP) and its structural homologs, fragile X syndrome 1 and 2 (FXR1 and FXR2). FMRP has a significant role in controlling the genesis and progression of various forms of human cancer.
Abrar I Aljohani +2 more
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Genes and pathways differentially expressed in the brains of Fxr2 knockout mice
Neurobiology of Disease, 2008 Fragile X syndrome is a common inherited form of mental retardation and originates from the absence of expression of the FMR1 gene. This gene and its two homologues, FXR1 and FXR2, encode for a family of fragile X related (FXR) proteins with similar ...
Sebastiano Cavallaro +2 more
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PLoS ONE, 2010 BackgroundExpansion of the CGG trinucleotide repeat in the 5'-untranslated region of the FMR1, fragile X mental retardation 1, gene results in suppression of protein expression for this gene and is the underlying cause of Fragile X syndrome.
Yahong Guo +2 more
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Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation [PDF]
Advanced ScienceN6‐methyladenosine (m6A) modification constitutes a crucial layer of post‐transcriptional regulations, but the landscape of its downstream readout effects remains less comprehensively understood. Therefore, we systematically assess the readout effects of
Zhou Huang +11 more
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Knockout mouse model for Fxr2: a model for mental retardation [PDF]
Human Molecular Genetics, 2002 Fragile X syndrome is a common form of mental retardation caused by the absence of the FMR1 protein, FMRP. Fmr1 knockout mice exhibit a phenotype with some similarities to humans, such as macro-orchidism and behavioral abnormalities. Two homologs of FMRP have been identified, FXR1P and FXR2P.
Lisa A Yuva-Paylor +2 more
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RNA-Binding Protein FXR2 Regulates Adult Hippocampal Neurogenesis by Reducing Noggin Expression [PDF]
Neuron, 2011 In adult mammalian brains, neurogenesis persists in the subventricular zone of the lateral ventricles (SVZ) and the dentate gyrus (DG) of the hippocampus. Although evidence suggest that adult neurogenesis in these two regions is subjected to differential regulation, the underlying mechanism is unclear.
Weixiang Guo +2 more
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Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis [PDF]
Human Molecular Genetics, 1997 Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as the major pathological symptoms in fragile X patients. FMRP is a cytoplasmic RNA-binding protein which cosediments with the 60S ribosomal subunit. Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2. These
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Comparing loss of individual fragile X proteins suggests strong links to cellular senescence and aging [PDF]
Cellular and Molecular Life SciencesMembers of the fragile X protein (FXP) family (FMR1, FXR1 and FXR2) are differentially expressed in most types of cancer and major neurodegenerative diseases.
Sonja Menge +9 more
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Functional amyloid protein FXR1 is recruited into neuronal stress granules [PDF]
PrionThe FXR1 protein regulates the stability and translation of a number of RNA molecules and plays an important role in the regulation of cellular processes under normal conditions and stress.
Anna A. Valina +7 more
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