Differential Expression of FMR1, FXR1 and FXR2 Proteins in Human Brain and Testis. [PDF]
Human Molecular Genetics, 1997 Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as the major pathological symptoms in fragile X patients. FMRP is a cytoplasmic RNA-binding protein which cosediments with the 60S ribosomal subunit. Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2. These
Rob Willemsen +2 more
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RNA-Binding Protein FXR2 Regulates Adult Hippocampal Neurogenesis by Reducing Noggin Expression [PDF]
Neuron, 2011 In adult mammalian brains, neurogenesis persists in the subventricular zone of the lateral ventricles (SVZ) and the dentate gyrus (DG) of the hippocampus. Although evidence suggest that adult neurogenesis in these two regions is subjected to differential regulation, the underlying mechanism is unclear.
Peng Jin, Weixiang Guo, Xinyu Zhao
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Functional amyloid protein FXR1 is recruited into neuronal stress granules [PDF]
PrionThe FXR1 protein regulates the stability and translation of a number of RNA molecules and plays an important role in the regulation of cellular processes under normal conditions and stress.
Anna A. Valina +7 more
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Deficient Sleep in Mouse Models of Fragile X Syndrome [PDF]
Frontiers in Molecular Neuroscience, 2017 In patients with fragile X syndrome (FXS), sleep problems are commonly observed but are not well characterized. In animal models of FXS (dfmr1 and Fmr1 knockout (KO)/Fxr2 heterozygote) circadian rhythmicity is affected, but sleep per se has not been ...
R. Michelle Saré +5 more
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Anti-ferroptosis exosomes engineered for targeting M2 microglia to improve neurological function in ischemic stroke [PDF]
Journal of NanobiotechnologyBackground Stroke is a devastating disease affecting populations worldwide and is the primary cause of long-term disability. The inflammatory storm plays a crucial role in the progression of stroke.
Yong Wang +10 more
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Delayed Development of Dendritic Spines in Fxr2 Knockout Mouse [PDF]
The Open Neuroscience Journal, 2009 Fragile X syndrome, the most common form of inherited mental retardation is caused by silencing of the Fmr1 (fragile x mental retardation-1) gene. Two mammalian homologues of Fmr1 have been identified: fragile X-related Pro- tein 1 (Fxr1) and Protein 2Fxr2.
Jinbo Deng, Anna Dunaevsky
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Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile [PDF]
Frontiers in Pharmacology, 2019 AimBile salt export pump (BSEP) have been confirmed to play an important role for bile acid canalicular export in the treatment of cholestasis. In this study, we investigated the stimulatory effect of emodin on BSEP signaling pathway in cholestasis ...
Xiao-Li Xiong +9 more
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Collateral metabolic vulnerabilities unveiled by loss of isozyme diversity in breast cancer [PDF]
Genome MedicineBackground Loss of isozyme diversity (LID) refers to the selective dependency on a single isozyme following the functional collapse of its redundant counterparts, uncovering a metabolic vulnerability.
Rui Ding +4 more
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The Use of “Retardation” in FRAXA, FMRP, FMR1 and Other Designations
Cells, 2022 The European Fragile X Network met in Wroclaw, Poland, November 2021, and agreed to work towards the eradication of the word “retardation” in regard to the naming of the fragile X gene (FRAXA) and protein (FMRP).
Jonathan Herring +2 more
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RNA-binding protein signaling in adult neurogenesis [PDF]
Frontiers in Cell and Developmental Biology, 2022 The process of neurogenesis in the brain, including cell proliferation, differentiation, survival, and maturation, results in the formation of new functional neurons.
Jackie Ngai-Man Chan +6 more
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