Results 151 to 160 of about 10,642 (179)

Immunocytochemical and Biochemical Characterization of FMRP, FXR1P, and FXR2P in the Mouse

Experimental Cell Research, 2000
Fragile X syndrome is caused by the absence of expression of the FMR1 gene. Both FXR1 and FXR2 are autosomal gene homologues of FMR1. The products of the three genes are belonging to a family of RNA-binding proteins, called FMRP, FXR1P, and FXR2P, respectively, and are associated with polyribosomes as cytoplasmic mRNP particles.
Bakker, CE, de Diego Otero, MY (Yolanda), Bontekoe, CJM (Carola), Raghoe, P, Luteijn, TK, Hoogeveen, Andre, Oostra, Ben, Willemsen, Rob   +7 more
openaire   +2 more sources

Abstract PR009: FMRP upregulation in cancer: Implicating FMRP-expressing cancer-associated fibroblasts in immune evasion

Cancer Research
Abstract Our research has uncovered a novel and significant role for Fragile-X-mental-retardation-protein (FMRP) in cancer biology, extending its well-established functions beyond neuronal development. In a recent Science publication (Zeng et al., 2022), we demonstrated that elevated FMRP levels drive immune evasion in various murine and
Simge Yucel, Nadine Fournier, Mireia Blanco Gomez, Douglas Hanahan   +3 more
openaire   +1 more source

FMRP and MicroRNAs in Neuronal Protein Synthesis

2018
Abstract New protein synthesis is critical for learning and memory. The discovery of ribosomes at synapses indicated the potential for local protein synthesis in response to stimulation. miRNAs play a key role in this process as evidenced by their role in normal neuronal development and function and in neurological disease.
Monica C. Lannom, Stephanie Ceman
openaire   +1 more source

The Role of FMRP in Stalled Ribosomes

Sossin, Wayne Steven (Supervisor)
openaire   +1 more source

FMRP phosphorylation modulates neuronal translation through YTHDF1

Molecular Cell, 2023
Yantao Chen
exaly  

Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development

Neuron, 2023
Xinyu Zhao
exaly  

Novel FMRP interaction networks linked to cellular stress

FEBS Journal, 2021
M -Reza Ahmadian, Mohamed Taha, Boris Gorg   +2 more
exaly  

Integrative omics indicate FMRP sequesters mRNA from translation and deadenylation in human neuronal cells

Molecular Cell, 2022
Lynne Maquat, Nobuyoshi Akimitsu, Tatsuaki Kurosaki   +2 more
exaly  

FMRP-dependent production of large dosage-sensitive proteins is highly conserved

Genetics, 2022
Qi Yin, Ethan Joseph Greenblatt, Allan Spradling   +2 more
exaly  

FMRP gains mitochondrial fission control

Nature Cell Biology
Carissa L. Sirois, Soraya O. Sandoval, Xinyu Zhao   +2 more
openaire   +2 more sources