Results 151 to 160 of about 14,329 (173)

Gene Therapy for Fragile X Syndrome, Challenges, and Promises. [PDF]

J Gene Med
Velinov M.
europepmc   +1 more source

A prospective cohort study of dietary intake and clinical-nutritional biomarkers in patients with periampullary malignancies undergoing pancreatoduodenectomy in Southeast Brazil. [PDF]

Support Care Cancer
Ribeiro MA, Dos Santos JS, da Silva Castro Perdoná G, Navarro AM.   +3 more
europepmc   +1 more source

Genetic Reduction of the Translational Repressors FMRP and 4E-BP2 Preserves Memory in Mouse Models of Alzheimer's Disease. [PDF]

Aging Cell
Ribeiro FC, Cozachenco D, Parkhill M, Rodrigue B, Borges C, Lacaille JC, Nader K, De Felice FG, Lourenco MV, Aguilar-Valles A, Sonenberg N, Ferreira ST.   +11 more
europepmc   +1 more source

FMR1 reduction alters cellular and circuit properties in human cortex

Singh A, Abbaspoor S, Chung L, Heinrich MJ, Stone S, Lidov H, Maio B, Phuoc-Tran T, Yoon J, Teng J, Martinez-Reyes C, Hammarlund E, Xu X, Rotenberg A, Gavornik J, Ferguson B, Farrell JS, Osterweil EK.   +17 more
europepmc   +1 more source

Ablation of Fmrp in Adult Neural Stem Cells Disrupts Hippocampus-Dependent Learning

Nature Medicine, 2011
Deficiency in fragile X mental retardation protein (FMRP) results in fragile X syndrome (FXS), an inherited form of intellectual disability. Despite extensive research, it is unclear how FMRP deficiency contributes to the cognitive deficits in FXS.
Peng Jin, Amelia J Eisch, Weixiang Guo
exaly   +2 more sources

FMRP Drives mRNP Targets Into Translationally Silenced Complexes

Molecular Cell
Fragile X Syndrome (FXS) is due to a deficiency in the ubiquitously expressed RNA-binding protein FMRP. While the mechanism of FMRP-mediated translational repression has been attributed primarily to ribosome stalling, we show using immunoprecipitations ...
Eric A J Simko, Christopher S Fraser, Elizabeth T Abshire   +2 more
exaly   +3 more sources

Fragile X Mental Retardation Protein (FMRP) Controls Diacylglycerol Kinase Activity in Neurons [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2016
Fragile X syndrome (FXS) is caused by the absence of the Fragile X Mental Retardation Protein (FMRP) in neurons. In the mouse, the lack of FMRP is associated with an excessive translation of hundreds of neuronal proteins, notably including postsynaptic ...
Barbara Bardoni, Jerome A.J. Becker, Jean-Louis Mandel   +2 more
exaly   +2 more sources

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FMRP Phosphorylation Modulates Neuronal Translation Through YTHDF1

Molecular Cell, 2023
Yantao Chen
exaly