Results 111 to 120 of about 25,023 (254)

A Single Centre Feasibility Study of Vacuum Assisted Breast Biopsy Excision as a Non‐Surgical Alternative for Selected Women With Borderline Breast Lesions

ANZ Journal of Surgery, EarlyView.
In a feasibility study at an Australian teaching hospital, women showed a clear preference for VAB Ex over surgical breast biopsy. The clinical outcomes confirm the safety and effectiveness of this approach. Overall, 90% of women had benign VAB Ex findings and did not require SBB, creating capacity in the healthcare system.
Gelareh Farshid, Suzanna Saloniklis, Kohei Funahashi, Amardeep Sidhu, Janne Bingham, Leong Tiong, Robert Whitfield, Melissa Bochner   +7 more
wiley   +1 more source

Therapeutic potential of a Bax inhibitor‐1/TMBIM6 antagonist (BIA) and its analogues in Aspergillus fumigatus‐induced asthma via dual targeting of AKT and epithelial‐derived inflammatory cytokines

British Journal of Pharmacology, EarlyView.
Background and Purpose Aspergillus fumigatus (A. fumigatus) exposure causes of severe allergic asthma, characterized by airway inflammation and epithelial dysfunction. TMBIM6 (Bax inhibitor‐1) has been implicated in airway epithelial stress responses and AKT signalling.
Young‐Jin Yu, Ahsan Ullah, Jisun Kim, Mehedi Hasan Bappi, Yerim Heo, Jin Hee Ahn, Hyun‐Kyoung Kim, Han‐Jung Chae   +7 more
wiley   +1 more source

MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10‐Mediated Angiogenesis

Cancer Science, EarlyView.
MEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Chengyu Wei, Xiangyu Liu, Shimin Hu, Xiaodie Shen, Yingli Liu, Xinxin Qin, Ye Zhou, Jianqi Zheng, Bingke Tian, Jingfang Hong, Yongxia Song, Di Wang, Linlin Peng, Jinxia Ding, Fang Wang, Hui Zhang, Shihao Zhang, Huan Qiu   +17 more
wiley   +1 more source

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

Long-Term Control of Human Papillomavirus-Related Focal Epithelial Hyperplasia in an Human Immunodeficiency Virus-Positive Patient Using Methylene Blue-Mediated Photodynamic Therapy. A Case Report. [PDF]

Lasers Surg Med
Araújo JCO, Paiva HC, Faara PMM, Junior OF, Ribeiro MS.   +4 more
europepmc   +1 more source

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Focal epithelial hyperplasia arising after delivery of metal-ceramic fixed dental prosthesis. [PDF]

J Adv Prosthodont, 2014
Park MW, Cho YA, Kim SM, Myoung H, Lee JH, Lee SK.   +5 more
europepmc   +1 more source

Discoid Lupus Erythematosus in Genital Skin: A Case Report and Review of the Literature

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Discoid lupus erythematosus (DLE) represents the most common variant of chronic cutaneous lupus erythematosus, a skin‐specific autoimmune disorder within the broader lupus erythematosus spectrum Clinically, DLE is characterized by erythematous, scaly plaques with areas of hyperpigmentation.
Ala' Abu‐Dayeh, Daniel Miller, Alessio Giubellino   +2 more
wiley   +1 more source

Transverse Histological Analysis of Scalp Seborrheic Dermatitis: A Novel Perspective

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Seborrheic dermatitis is a chronic inflammatory disease affecting seborrheic areas of the skin, including the scalp. It is often confused with scalp psoriasis due to similar clinical and histopathological features. Objective This study described microscopic changes in the pilosebaceous unit in seborrheic dermatitis (SDS) using cross‐
Tatiane Elen de Souza, Almut Böer‐Auer, Betina Werner   +2 more
wiley   +1 more source

Diagnostic Utility of the Milan System for Reporting Salivary Gland Cytopathology With Cytohistological Correlation

Cytopathology, EarlyView.
This retrospective study reviews 111 salivary gland fine‐needle aspiration cytology (FNAC) cases collected over an 11‐year period and reclassifies them according to the Milan System for Reporting Salivary Gland Cytopathology. Cytology‐histopathology correlation was performed for excision specimens, confirming the system's accuracy in distinguishing non‐
Shifa F. Khan, Raji T. Naidu, Susan Cherian, Uma P. Chaturvedi, Prachi R. Gaddam   +4 more
wiley   +1 more source