Results 51 to 60 of about 2,490,685 (297)

Selected issues of oral diseases in the work of a district nurse and primary care nurse

Pielęgniarstwo XXI Wieku, 2018
SELECTED ISSUES OF ORAL DISEASES IN THE WORK OF A DISTRICT NURSE AND PRIMARY CARE NURSE Introduction. Oral health condition and its influence on general health is widely known and does not raise any doubts.  Aim.
Małgorzata Migut, Bogumił Lewandowski
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Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Severe Infections after Tooth Removal: a Retrospective Cohort Study

eJournal of Oral Maxillofacial Research
Objectives: The purpose of this retrospective cohort study was to determine the characteristics of patients hospitalized with severe infections after tooth removal.
Klara Grønhøj, Rasmus Søndenbroe, Merete Markvart, Simon Storgård Jensen   +3 more
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Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Factors Contributing to the Spread of Odontogenic Infections : A prospective pilot study

Sultan Qaboos University Medical Journal, 2009
Objectives: Spreading odontogenic infections (SOI) are the commonest type of serious infections encountered in the orofacial region. A prospective multi-centre study was conducted in the West of Scotland to investigate the contributing role of social ...
Abdulaziz A Bakathir, Khursheed F Moos, Ashraf F Ayoub, Jeremy Bagg   +3 more
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Airway management and outcomes in surgical drainage of severe odontogenic infections: a retrospective cohort study

Brazilian Journal of Anesthesiology
Background: Severe odontogenic infections requiring surgical drainage pose significant airway management challenges. This study aimed to compare perioperative characteristics and clinical outcomes between patients managed with conventional laryngoscopy ...
Karam Azem, Adham Kashkush, Benjamin Zribi, Eitan Mangoubi, Shai Fein, Roussana Aranbitski, Sharon Orbach-Zinger, Esmat Najjar, Philip Heesen, Gal Avishai, Dror Bar Hai, Gavriel Chaushu, Daya Masri   +12 more
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Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

Morphofunctional and etiopathogenic connections in the pathology of endodontic and periodontal tissues

Эндодонтия Today, 2020
In this article described the current understanding of morphological and functional relationship between endodontics and periodontium. It is noted that the relationship between endodontics and periodontal performed by vascular and tubular ways.

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