Results 131 to 140 of about 37,634 (351)

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

Prophylactic third molar removal: are oral surgeons and orthodontists aligned in preventive approaches?

BMC Oral Health
Background There is a general consensus among dental professionals regarding the extraction of impacted third molars in the presence of clinical symptoms. However, there is less agreement on the management of asymptomatic third molars.
Ipek Necla Guldiken, Serap Gulsever, Yagmur Malkoc, Zeynep Cukurova Yilmaz, Mutlu Ozcan   +4 more
doaj   +1 more source

Dental Focal Infection Associated with Skin Diseases. A Specific Reference to .ALPHA.-Hemolytic Cocci.

, 2001
Chikara Iwai, Shinichi Tsurusako, Yoshiro Ohara, Masatsugu Obuchi, Natsuki Segami   +4 more
openalex   +2 more sources

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Role of Dentists in Prescribing Opioid Analgesics and Antibiotics: An Overview [PDF]

, 2018
Ackerman, Al-Huwayrini, Aldous, Aminoshariae, Amir Azarpazhooh, Ashrafioun, Baker, Baur, Bax, Birrenbach, Bohnert, Budnitz, Cabana, Cadieux, Center for Disease Control and Prevention, Christopher Okunseri, Conly, Cooper, Crane, Cunha, Dar-Odeh, De-Bem, Denisco, Dionne, Dirks, Dodd, Dowell, Drekonja, Ellison, European Centre for Disease Prevention and Control (CDC), Fazakerley, Fleming-Dutra, Forbes, Gonzales, Gordon, Grimshaw, Grol, Guy, Haas, Hasegawa, Hicks, Irvine, John, Kakoei, Katie J. Suda, Katz, Kumar, Lam, Levy, Lewis, Little, Logan, Longman, Ma, Martin, McCauley, Mutlu, Nima Laghapour, Ong, Ostini, Pallasch, Pallasch, Pallasch, Palmer, Palmer, Paluck, Paulozzi, Porucznik, Pynn, Ralph Dana, Rasubala, Rigoni, Rodriguez-Nunez, Runciman, Saadat, Samaranayake, Sawair, Schumock, Seager, Segura-Egea, Shehab, Smith, Spurling, Steed, Steinmetz, Substance Abuse and Mental Health Services Administration, Suda, Sweeney, Thornhill, Thornhill, Tufts Health Care Institute, Van der Sanden, Vanderweil, Vessal, Volkow, Wall, Wang, Wright, Yingling, Zimmerman   +99 more
core   +2 more sources

Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays

Advanced Science, EarlyView.
ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen, Yuman Li, Chenyu Deng, Leran Li, Zhewen Hu, Boon Chin Heng, Yuting Niu, Shiyu Sun, Min Gao, Xiaopei Chi, Ying He, Mingming Xu, Ying Huang, Xuliang Deng   +13 more
wiley   +1 more source

STUDY OF THE COMPOSITION OF MICROFLORA OF ROOT CANALS IN PRIMARY AND CHRONIC PERIODONTITIS

Український стоматологічний альманах
The problem of chronic focal infection of the pulp and periodontal tissues is relevant for both therapeutic and surgical dentistry. It has been proven that the long-term effect of microbial flora on the filling material, root dentin, periodontium and ...
S.O. Priadko, I.P. Koshova, A.V. Samoilenko   +2 more
doaj   +1 more source

Ogniska Zakażenia Pochodzenia Zębowego U Chorych Kardiologicznych = Dental Focal Infections In Patients With Cardiac Issues

, 2015
Anna Janas‐Naze, Adam Chiżyński, Aleksandra Szczepkowska, Anna Olborska, Piotr Osica   +4 more
openalex   +2 more sources

Dental focal infection-induced ventricular and spinal canal empyema: A case report

, 2020
Hang Xue, Xiaohui Wang, Lin Shi, Qiang Wei, Yiming Zhang, Hongfa Yang   +5 more
openalex   +1 more source