Results 51 to 60 of about 89,265 (271)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Monro-Kellie 2.0: The dynamic vascular and venous pathophysiological components of intracranial pressure [PDF]
, 2016 For 200 years, the ‘closed box’ analogy of intracranial pressure (ICP) has underpinned neurosurgery and neuro-critical care. Cushing conceptualised the Monro-Kellie doctrine stating that a change in blood, brain or CSF volume resulted in reciprocal ...
Wilson, MH
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Vertical and horizontal transmission of plant viruses: two extremes of a continuum?
npj VirusesParasites have a variety of mechanisms to be transmitted to new susceptible hosts, which can be largely grouped in two main modes: vertical (i.e., from parents to the offspring) and horizontal (i.e., between hosts regardless of descent).
Lucía García-Ordóñez, Israel Pagán
doaj +1 more source
Non-midical control of parasitic worms in pigs [PDF]
, 2003 Generally there is a higher prevalence of intestinal parasites in organic pigs compared to conventional indoor pigs. It may be possible to reduce infection levels by ensuring that new animals are parasite free, using a moderate stocking rate, co-grazing ...
Mejer, Helena, Roepstroff, Allan
core
One Health – an Ecological and Evolutionary Framework for tackling Neglected Zoonotic Diseases [PDF]
, 2015 Understanding the complex population biology and transmission ecology of multihost parasites has been declared as one of the major challenges of biomedical sciences for the 21st century and the Neglected Zoonotic Diseases (NZDs) are perhaps the most ...
Adamo +135 more
core +5 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Textual Mediation in Simulated Nursing Handoffs: Examining How Student Writing Coordinates Action [PDF]
, 2019 In clinical nursing simulations, a group of students provide care for a robotic patient during a structured scenario. As care is transferred from one group to another, they participate in a patient handoff, with outgoing students passing key information ...
Campbell, Lillian
core +1 more source
Studies on the rejection of the transplanted homologous dog liver. [PDF]
, 1961 Dogs in which livers have been replaced with hepatic homografts usually die in 5 to 10 days. Liver metabolism is not detectably abnormal at first, but gradual deterioration of function commences on the fourth or fifth day.
BROCK, DR +3 more
core +1 more source