Results 111 to 120 of about 6,812,052 (298)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Journal of Aceh Physics Society, 2018 Salah satu gempa bumi yang berdampak pada kerusakan rumah penduduk telah terjadi di Sumatra tepatnya adalah daerah Pidie Jaya pada tanggal 7 Desember 2016, sebesar Mw 6.5.
Qadariyah Qadariah +2 more
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Comparison of solutions for microseismic focal mechanism estimation [abstract]. [PDF]
Geology, Geophysics & Environment, 2016 Paweł Wandycz +2 more
openaire +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2020 This dataset contains the seismic data and the velocity model used in the manuscript entitled "General Dislocation Source Model and its Application to Microseismic Focal Mechanism Inversion" submitted to Journal of Geophysical Research-Solid ...
Jinlai Hao, Han Li, Xu Chang
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Focal mechanisms of the Southeastern Alps and surroundings
, 2020 This is a focal mechanism dataset of 772 earthquakes that occurred in the southeastern Alps and surrounding areas ( latitude 45°N-47.5°N and longitude 10°E-15°E) from 1928 to 2019 with 1.8 ≤ M ≤ 6.5. To provide a comprehensive set of revised information,
Bressan Gianni +4 more
core +1 more source