Results 131 to 140 of about 80,952 (305)

A standard gamble study to determine health state utilities associated with seizures in glioma in the UK

Health and Quality of Life Outcomes
Background Glioma are infiltrative primary brain tumours, which despite treatment, lead to a substantial reduction in life expectancy. Seizures are a common symptom of glioma, and have a serious impact on patient health related quality of life (HRQoL ...
Tomos Robinson, Matthew Breckons, Helen Bulbeck, Michael D. Jenkinson, Robin Grant, Luke Vale   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Atonic phenomena in focal seizures: Nomenclature, clinical findings and pathophysiological concepts

, 2012
Atonic seizures have traditionally been described in patients with generalized epilepsies; however, ictal atonia is increasingly recognized as a phenomenon of focal seizures.
Diehl, Beate, Kovac, Stjepana
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Epilepsy with migrating focal seizures

, 2021
To report new sporadic cases and 1 family with epilepsy of infancy with migrating focal seizures (EIMFSs) due to KCNT1 gain-of-function and to assess therapies' efficacy including quinidine.
VHIR Vall d'Hebron Institut de Recerca, Billette de Villemeur, Thierry, Barcia, Giulia, Kuchenbuch, Mathieu, Ciorna, Viorica, Macaya Ruiz, Alfons, Eisermann, Monika, Kaminska, Anna, Bonnefont, Jean-Paul, Dubois, Fanny, Gobin-Limballe, Stéphanie, Nava, Caroline, Chemaly, Nicole, Barthez, Marie-Anne, Nabbout, Rima, Villeneuve, Nathalie, Doummar, Diane, Bahi-Buisson, Nadia, Milh, Mathieu, Auvin, Stéphane, Lambert, Laetitia, Boddaert, Nathalie   +21 more
core  

Spotlight on perampanel in the management of seizures: design, development and an update on place in therapy

Drug Design, Development and Therapy, 2017
Michele A Faulkner1,2 1Department of Pharmacy Practice, 2Department of Neurology, Creighton University Schools of Pharmacy and Medicine, Omaha, NE, USA Purpose: Perampanel is a first-in-class antiepileptic medication approved for the treatment of partial
Faulkner MA
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Investigação de alterações no nível e na ativação de proteínas cinases no neocórtex e no hipocampo de camundongos submetidos ao modelo de kindling por pentilenotetrazol [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2014.A epileptogênese é um processo que envolve a sinalização celular e a neuroplasticidade. As proteínas
Ben, Juliana
core