Results 151 to 160 of about 80,952 (305)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

CLINICAL FEATURES OF FOCAL EPILEPSY WITH SECONDARY BILATERAL SYNCHRONIZATION ON EEG AMONG ADOLESCENTS

Эпилепсия и пароксизмальные состояния, 2016
: current work is dedicated to analysis of features of clinical and encephalographic manifestations of focal epilepsy with secondary bilateral synchronization on EEG and onset in adolescence.
T. R. Sadykov, A. G. Rumyantsev, V. O. Generalov, Yu. V. Kazakova   +3 more
doaj  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Noncanonical spike-related BOLD responses in focal epilepsy

, 2008
Till now, most studies of the Blood Oxygen Level-Dependent (BOLD) response to interictal epileptic discharges (IED) have assumed that its time course matches closely to that of brief physiological stimuli, commonly called the canonical event-related ...
Lemieux, L., Walker, M.C., Duncan, J.S., Laufs, H., David Carmichael, Louis Lemieux, John S. Duncan, Carmichael, D., Joseph Suresh, Paul, J.S., Matthew C. Walker, Helmut Laufs   +11 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

May focal epileptic seizures be considered a marker of TIAs?

, 1986
Late-onset focal epileptic seizures occurred in 8 patients with ischemic cerebro-vascular disease (ICVD) and were associated with TIAs in 6 of them. History, physical, laboratory, ancillary examinations and follow-up revealed no other disease which might
COCITO, LEONARDO, LOEB, CHARLES WALTER
core  

Focal to Bilateral Tonic–Clonic Seizures in Newly Diagnosed Focal Epilepsy

Presence of focal to bilateral tonic–clonic seizures (FBTCS) in focal epilepsy is associated with increased morbidity and mortality. Risk factors for FBTCS are poorly understood, and little is known regarding FBTCS recurrence after treatment initiation ...
Agashe, Shruti, French, Jacqueline A., Gidal, Barry, Cascino, Gregory D., Devinsky, Orrin, Klein, Pavel, Barnard, Sarah, Holmes, Manisha G., Pellinen, Jacob, Abou-Khalil, Bassel, Fox, Jonah   +10 more
core   +1 more source

Focal seizures during simulated driving: A pilot study. [PDF]

Epilepsia
Nilsson E, Zelenika Zeba M, Strandberg J, Lundgren P, Zelano J.   +4 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Refractory focal seizures occurred in clusters in a girl with a de novo mutation of the ATP6V0A1 gene: a case report. [PDF]

J Med Case Rep
Peng L, Wei C, Zhang Y, Zhang Q, Wang W, Bao X.   +5 more
europepmc   +1 more source