Results 61 to 70 of about 80,952 (305)

EEG–fMRI mapping of asymmetrical delta activity in a patient with refractory epilepsy is concordant with the epileptogenic region determined by intracranial EEG

, 2006
We studied a patient with refractory focal epilepsy using continuous EEG-correlated fMRI. Seizures were characterized by head turning to the left and clonic jerking of the left arm, suggesting a right frontal epileptogenic region.
Walker, M.C., Lemieux, L., Hamandi, Khalid, Smith, Shelagh, Laufs, Helmut, Walker, Matthew C., Smith, S., Lemieux, Louis, Duncan, John S., Duncan, J.S., Laufs, H., Hamandi, K., Scott, Catherine, Scott, C.   +13 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Movement disorders phenomenology in focal motor seizures

, 2018
Introduction: Although focal motor seizures may resemble one or more movement disorders their phenomenology and prevalence remain uncertain. Methods: To examine the extent to which focal motor seizures can present with a phenomenology fulfilling ...
Di Gennaro, Giancarlo, Defazio G, Fabbrini G., Iorio, Raffaele, Fabbrini, Giovanni, Borlot, Felipe, Di Bonaventura C, Fasano, Alfonso, Andrade D, Striano P., Espay, Alberto J., Fasano A, Bove F., Andrade, Danielle, Di Bonaventura, Carlo, Bui E, Espay AJ, Fabbrini G, Luigetti M., Di Gennaro G., Munhoz R. P., Defazio, Giovanni, Andrade D., Borlot F, Fasano A., Defazio G., Luigetti, Marco, Morgante, Francesca, Katzberg H., Morgante F, BOVE, FRANCESCO, Bui E., Di Bonaventura C., Borlot F., Luigetti M, Katzberg, Hans, Striano, Pasquale, Iorio R3, Bui, Esther, Morgante F., Iorio R., Di Gennaro G, Munhoz RP, Berardelli, Alfredo, Espay A. J., Striano P, Katzberg H, Bove F, Munhoz, Renato P., Berardelli A.   +49 more
core   +1 more source

Anticonvulsant effects of cenobamate in chemically and electrically induced seizure models in rodents

Heliyon, 2023
Background: Cenobamate is an antiseizure medication used to treat partial-onset (focal) seizures. It is a molecule with one chiral center and a unique dual mechanism of action: enhancement of fast and slow inactivation of sodium channels with ...
Susan M. Melnick, Yujin Shin, Kelli J. Glenn   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A Study of Clinical and Etiological Profile of Focal Seizures [PDF]

, 2016
BACKGROUND: The etiology of seizures is directly linked to the type of seizure. In focal seizures, localisation of abnormalities ranges from 28 to 80%. as observed in various studies.
Revathy, V
core  

Neonatal focal seizures and hypomagnesemia : a case report

, 2016
Background In seizures caused by electrolytes disorders, a prompt diagnosis allows an appropriate treatment and reduces the risk of neurological complications.
M.B.M. Mazzoni, A. M. Cappellari, M. Belli, G.P. Milani, G. Tardini, E.F. Fossali   +5 more
core   +1 more source

‐epilepsy in infancy with migrating focal seizures

, 2021
International audienceOBJECTIVE: This study was undertaken to investigate how gain of function (GOF) of slack channel due to a KCNT1 pathogenic variant induces abnormal neuronal cortical network activity and generates specific electroencephalographic ...
Maxime Yochum, Kuchenbuch, Mathieu, Sauleau, Paul, Pascal Benquet, Rima Nabbout, Benquet, Pascal, Yochum, Maxime, Wendling, Fabrice, Paul Sauleau, Modolo, Julien, Nabbout, Rima, Mathieu Kuchenbuch, Fabrice Wendling, Julien Modolo   +13 more
core   +1 more source