Results 81 to 90 of about 511,553 (294)
Epilepsia OpenObjective Amount of seizure‐free days is a critical determinant of quality of life (QoL) in patients with drug‐resistant epilepsy (DRE). The fractions of patients experiencing prolonged periods of seizure freedom with adjunctive vagus nerve stimulation ...
Naoki Tani +6 more
doaj +1 more source
Unusual seizure evolution: Focal-general-focal-general
Epilepsy & Behavior Case Reports, 2018 Seizure types have been described that do not conform to traditional classification schemes. We present another unusual type characterized by focal onset with secondary generalization, that is followed immediately by continued focal activity that generalizes again without an intervening break.
Christopher Smelick +3 more
openaire +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
May focal epileptic seizures be considered a marker of TIAs?
, 1986 Late-onset focal epileptic seizures occurred in 8 patients with ischemic cerebro-vascular disease (ICVD) and were associated with TIAs in 6 of them. History, physical, laboratory, ancillary examinations and follow-up revealed no other disease which might
COCITO, LEONARDO, LOEB, CHARLES WALTER
core +1 more source
Hyperglycemia-induced Focal Seizures: A Case Report
Medical Journal of Dr. D.Y. Patil VidyapeethWe report a 52-year-old male with a 3-year history of seizure disorder presenting with increased frequency of focal seizures over one week. Despite compliance with multiple antiepileptic drugs, seizures persisted.
Khushboo Hatekar +4 more
doaj +1 more source
Febrile Seizures in Idiopathic/Genetic Generalized and Self-Limited Focal Epilepsies
, 2020 Objectives: Febrile seizure (FS) is the most common form of childhood seizures. Furthermore, idiopathic/generalized and focal/self-limited epilepsies present at the similar age-range. They usually have a favorable outcome.
Veysi DEMİRBİLEK +9 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Acute Striato-Cortical Synchronization Induces Focal Motor Seizures in Primates
, 2020 International audienceObjective: Whether the basal ganglia are involved in the cortical synchronization during focal seizures is still an open question.
Aupy, Jerome +8 more
core +1 more source