Results 91 to 100 of about 511,553 (294)

A study on the epidemiology of incident seizures in patients with neuropsychiatric disorders [PDF]

, 2015
Pharmacoepidemiology studies use and effects of drugs in large numbers of people. It thus allows the investigation and quantification of rare beneficial or adverse events of drugs used by the general population under “real-world” conditions ...
Blöchliger, Marlene Susanne
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Myelin oligodendrocyte glycoprotein antibody-associated isolated seizures in children: a retrospective single-center case series

Frontiers in Immunology
Background and purposeIsolated seizures represent a distinct, rare, and underrecognized phenotype of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD).
Kang Liu, Kang Liu, Kang Liu, Panhui Yu, Panhui Yu, Panhui Yu, Liyao Ma, Liyao Ma, Liyao Ma, Yubing Gong, Yubing Gong, Yubing Gong, Hongru Lu, Hongru Lu, Hongru Lu, Wei Wang, Wei Wang, Wei Wang, Fang Chen, Fang Chen, Fang Chen   +20 more
doaj   +1 more source

A unique case of nontraumatic femoral neck fracture following epilepsia partialis continua

Epilepsy and Behavior Case Reports, 2015
People with epilepsy are more accident prone than the non-epilepsy population. Bone fractures are most often due to seizure-related falls. However, seizures themselves, in particular generalized tonic-clonic seizures, may also cause fractures, e.g.
Karl O. Nakken
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Mechanisms underlying different onset patterns of focal seizures. [PDF]

, 2017
Focal seizures are episodes of pathological brain activity that appear to arise from a localised area of the brain. The onset patterns of focal seizure activity have been studied intensively, and they have largely been distinguished into two types-low ...
Wang, Yujiang, Valentin, Antonio, Yujiang Wang, Gonzalo Alarcon, Marcus Kaiser, Andrew J Trevelyan, Antonio Valentin, Peter N Taylor, Kaiser, Marcus, Trevelyan, Andrew J, Alarcon, Gonzalo, Taylor, Peter N   +11 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Seizures in the prehospital setting

, 2010
Seizures are a common occurrence in the prehospital arena, however, with numerous conditions causing seizures, prehospital clinicians can be left with a dilemma in the treatment of these patients. Patients who are actively seizing will predominately have
Cashmore, Jamie
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source