Results 231 to 240 of about 2,268,232 (304)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Artificial Intelligence in Eating Disorder Treatment: A Qualitative Analysis of Clinical Opportunities, Barriers, and Ethical Considerations From Multi-Disciplinary Focus Groups. [PDF]

Int J Eat Disord
Maas J, Franssen S, Petkovic M, Cardona Cano S, Dingemans AE, van Oosterzee AM, Slof-Op 't Landt MCT, Talavera Martinez E, Vreeswijk CMJM, Simeunovic-Ostojic M.   +9 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Types of Challenges and Barriers in Accessing Paediatric Palliative Care in Romania: A Qualitative Study Based on Focus Groups Guided by a Semi-Structured Discussion Guide. [PDF]

Medicina (Kaunas)
Hizanu Dumitrache M, Stafie L, Plesea-Condratovici A, Mindru DE, Salim C, Elkan EM, Duceac Covrig M, Matei MN, Dinu CA, Duceac LD.   +9 more
europepmc   +1 more source

Nurses' Perspectives on Evidence Dissemination Barriers and Large Language Model-Based Support: Qualitative Study Using Focus Groups and Nominal Group Technique. [PDF]

J Med Internet Res
Ruan J, Tang Y, Wei Z, Xing W, Hu Y.
europepmc   +1 more source

Understanding Behavioral Influences on Eating Disorders and App Engagement to Inform Eating Disorder App Development: Qualitative Online Focus Groups With Adults With Lived Experience. [PDF]

JMIR Form Res
Thomas PC, Rowe S, Curtis K, Perowne R, Bark P.   +4 more
europepmc   +1 more source

Advancing soundscape assessment in open-plan offices: Insights from expert focus groups. [PDF]

Build Acoust
Rachman Z, Aletta F, Kang J.
europepmc   +1 more source