Results 71 to 80 of about 350,975 (342)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Recent advances in nonlinear optics for bio-imaging applications
Opto-Electronic Advances, 2020 Nonlinear optics, which is a subject for studying the interaction between intense light and materials, has great impact on various research fields. Since many structures in biological tissues exhibit strong nonlinear optical effects, nonlinear optics has
Zhang Silu +7 more
doaj +1 more source
Grazing-Incidence Neutron Optics based on Wolter Geometries [PDF]
, 2008 The feasibility of grazing-incidence neutron imaging optics based on the Wolter geometries have been successfully demonstrated. Biological microscopy, neutron radiography, medical imaging, neutron crystallography and boron neutron capture therapy would ...
Gubarev, M. V. +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Meta-optical imaging at thermal wavelengths
JPhys PhotonicsThe field of meta-optics has grown to include metalenses spanning the ultraviolet to terahertz regimes. Imaging is a key application of meta-optics, with recent works demonstrating meta-optical imaging with advanced functionalities including wide field ...
Anna Wirth-Singh +4 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A review of dielectric optical metasurfaces for wavefront control
Nanophotonics, 2018 During the past few years, metasurfaces have been used to demonstrate optical elements and systems with capabilities that surpass those of conventional diffractive optics.
Kamali Seyedeh Mahsa +3 more
doaj +1 more source
Multiwavelength active optics Shack-Hartmann sensor for seeing and turbulence outer scale monitoring
, 2014 Real-time seeing and outer scale estimation at the location of the focus of a telescope is fundamental for the adaptive optics systems dimensioning and performance prediction, as well as for the operational aspects of instruments.
Martinez, Patrice
core +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Development of Focusing Plasma Mirrors for Ultraintense Laser-Driven Particle and Radiation Sources
Quantum Beam Science, 2018 Increasing the peak intensity to which high power laser pulses are focused can open up new regimes of laser-plasma interactions, resulting in the acceleration of ions to higher energies and more efficient generation of energetic photons.
Robbie Wilson +12 more
doaj +1 more source