Results 81 to 90 of about 350,383 (340)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Keldysh Field Theory for Driven Open Quantum Systems

, 2016
Recent experimental developments in diverse areas - ranging from cold atomic gases over light-driven semiconductors to microcavity arrays - move systems into the focus, which are located on the interface of quantum optics, many-body physics and ...
Buchhold, M., Diehl, S., Sieberer, L. M.
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Quantum superiority for verifying NP-complete problems with linear optics

, 2017
Demonstrating quantum superiority for some computational task will be a milestone for quantum technologies and would show that computational advantages are possible not only with a universal quantum computer but with simpler physical devices.
Arrazola, Juan Miguel, Diamanti, Eleni, Kerenidis, Iordanis   +2 more
core   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Holographic optical trapping

, 2005
Holographic optical tweezers use computer-generated holograms to create arbitrary three-dimensional configurations of single-beam optical traps useful for capturing, moving and transforming mesoscopic objects.
Allen, Alonzo, Arlt, Ashkin, Ashkin, Crocker, Curtis, Curtis, Dufresne, Dufresne, Gahagan, Garces-Chavez, Grier, Guo, He, He, Hughes, Jesacher, Jordan, Korda, Koss, Ladavac, Ladavac, Leach, Liesener, MacDonald, Meister, Melville, Mogensen, Neto, O'Neil, Polin, Reicherter, Reimann, Roichman, Sacks, Sasaki, Simpson, Sinclair, Soskin, Sundbeck   +40 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Wavefront correction with image-based interferometric focus sensing in two-photon microscopy

Nanophotonics
Adaptive optics is a technology that corrects wavefront distortions to enhance image quality. Interferometric focus sensing (IFS), a relatively recently proposed method within the field of adaptive optics, has demonstrated effectiveness in correcting ...
Yang Ruiwen, Yang Yanlong, Wu Tengfei, Zhang Yang, Dan Dan, Min Junwei, Yu Xianghua, Dai Taiqiang, Kong Liang, Li Li, Yao Baoli   +10 more
doaj   +1 more source

Through-focus scanning optical microscopy (TSOM) considering optical aberrations: practical implementation

Optics Express, 2015
Through-focus scanning optical microscopy (TSOM) method based on use of a library, which is composed of simulated defocused images of nanosized silicon lines on the top of a monocrystalline silicon substrate, is demonstrated. The images are simulated using Finite-Differences in Time-Domain (FDTD) method taking into account optical aberrations of the ...
Maxim, Ryabko, Alexey, Shchekin, Sergey, Koptyaev, Alexey, Lantsov, Anton, Medvedev, Alexander, Shcherbakov, Sang Yoon, Oh   +6 more
openaire   +2 more sources