Results 11 to 20 of about 11,077,430 (333)
A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B. [PDF]
ChemMedChem, 2013 Zeng LF +6 more
europepmc +2 more sources
Molecules, 2022 Inhibitors of epigenetic writers such as DNA methyltransferases (DNMTs) are attractive compounds for epigenetic drug and probe discovery. To advance epigenetic probes and drug discovery, chemical companies are developing focused libraries for epigenetic ...
José L. Medina-Franco +2 more
doaj +1 more source
Journal of Medicinal Chemistry, 2022 We here describe a computational approach (POEM: Pocket Oriented Elaboration of Molecules) to drive the generation of target-focused libraries while taking advantage of all publicly available structural information on protein-ligand complexes.
Merveille Eguida +4 more
semanticscholar +1 more source
Frontiers in Microbiology, 2022 Synthetic antibodies have been engineered against a wide variety of antigens with desirable biophysical, biochemical, and pharmacological properties.
Bharathikumar Vellalore Maruthachalam +4 more
doaj +1 more source
Phenotypic screening of a focused nucleoside library [PDF]
, 2016 Hulpia, Fabian, Van Calenbergh, Serge
core +2 more sources
Designing focused libraries using MoSELECT [PDF]
Journal of Molecular Graphics and Modelling, 2002 When designing a combinatorial library it is usually desirable to optimise multiple properties of the library simultaneously and often the properties are in competition with one another. For example, a library that is designed to be focused around a given target molecule should ideally have minimum cost and also contain molecules that are bioavailable.
Gillet, V.J. +3 more
openaire +2 more sources
Computational and Structural Biotechnology Journal, 2012 The combination of computational and directed evolution methods has proven a winning strategy for protein engineering. We refer to this approach as computer-aided protein directed evolution (CAPDE) and the review summarizes the recent developments in ...
Rajni Verma +2 more
doaj +3 more sources
Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. [PDF]
J Am Chem Soc, 2010 Werneburg M +8 more
europepmc +2 more sources
The Specialized RF Elements Library for Trusted Transceiver VLSI Design
Безопасность информационных технологий, 2023 Results of designing the specialized RF elements library intended for use in the CMOS 180 nm process are presented. The RF library includes a set of RF MOSFETs for amplifiers and switches design, three types of varactors based on the MOS-structure ...
Denis I. Sotskov +6 more
doaj +1 more source
Synthetic Antibody Libraries Focused Towards Peptide Ligands [PDF]
Journal of Molecular Biology, 2008 Synthetic antibody libraries have proven immensely useful for the de novo isolation of antibodies without the need for animal immunization. Recently, focused libraries designed to recognize particular classes of ligands, such as haptens or proteins, have been employed to facilitate the selection of high-affinity antibodies.
Christian W, Cobaugh +4 more
openaire +2 more sources