Synthesis of Diazacyclic and Triazacyclic Small-Molecule Libraries Using Vicinal Chiral Diamines Generated from Modified Short Peptides and Their Application for Drug Discovery [PDF]
PharmaceuticalsSmall-molecule probes are powerful tools for studying biological systems and can serve as lead compounds for developing new therapeutics. Especially, nitrogen heterocycles are of considerable importance in the pharmaceutical field.
Mukund P. Tantak +4 more
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Application of temperature-responsive HIS-tag fluorophores to differential scanning fluorimetry screening of small molecule libraries [PDF]
Frontiers in Pharmacology, 2022 Differential scanning fluorimetry is a rapid and economical biophysical technique used to monitor perturbations to protein structure during a thermal gradient, most often by detecting protein unfolding events through an environment-sensitive fluorophore.
Michael H. Ronzetti +8 more
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Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries [PDF]
JHEP Reports, 2023 Background & Aims: Chronic hepatitis delta is the most severe form of chronic viral hepatitis and is associated with faster progression towards cirrhosis, liver decompensation, and hepatocellular carcinoma.
Eirini D. Tseligka +5 more
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The evolution and application of RNA-focused small molecule libraries. [PDF]
RSC Chem BiolHits identified from screening diverse compound libraries against RNA targets can be used to inform design of RNA-focused libraries via computational techniques to calculate chemical similarity and physicochemical properties.
Taghavi A +6 more
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Gypsum-DL: an open-source program for preparing small-molecule libraries for structure-based virtual screening [PDF]
Journal of Cheminformatics, 2019 Computational techniques such as structure-based virtual screening require carefully prepared 3D models of potential small-molecule ligands. Though powerful, existing commercial programs for virtual-library preparation have restrictive and/or expensive ...
Patrick J. Ropp +7 more
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PLoS Biology, 2004 Biological in vitro selection techniques, such as RNA aptamer methods and mRNA display, have proven to be powerful approaches for engineering molecules with novel functions.
David R Halpin, Pehr B Harbury
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Small-molecule discovery from DNA-encoded chemical libraries [PDF]
Chemical Society Reviews, 2011 Researchers seeking to improve the efficiency and cost effectiveness of the bioactive small-molecule discovery process have recently embraced selection-based approaches, which in principle offer much higher throughput and simpler infrastructure requirements compared with traditional small-molecule screening methods.
David Liu, Christoph E Dumelin
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Inkjet Bioprinting on Parchment Paper for Hit Identification from Small Molecule Libraries [PDF]
ACS Omega, 2019 Jungmi Lee +2 more
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AI‐Augmented Iterative Screening of Libraries Against RNA Targets (AISLAR) Boosts Discovery of SAR‐Tractable RNA Binders and Rational Analog Design [PDF]
Small ScienceSmall molecules that target RNA are emerging as a powerful therapeutic modality, although deriving structure–activity relationships (SARs) remains a major challenge.
Haruhiko Hattori +6 more
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Selecting, Acquiring, and Using Small Molecule Libraries for High‐Throughput Screening [PDF]
Current Protocols in Chemical Biology, 2012 Noel Southall
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