Results 11 to 20 of about 109,018 (245)
High throughput screening of small molecule libraries for modifiers of radiation responses [PDF]
International Journal of Radiation Biology, 2011 William Mcbride +2 more
exaly +2 more sources
Highly multiplexed selection of RNA aptamers against a small molecule library
PLoS ONE, 2022 Applications of synthetic biology spanning human health, industrial bioproduction, and ecosystem monitoring often require small molecule sensing capabilities, typically in the form of genetically encoded small molecule biosensors.
Brent Townshend +2 more
doaj +2 more sources
Recent Advances in Divergent Synthetic Strategies for Indole-Based Natural Product Libraries
Molecules, 2022 Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-molecule libraries for high-throughput screening (HTS) and high-content ...
Taegwan Kim, Min Woo Ha, Jonghoon Kim
doaj +1 more source
Highly parallel translation of DNA sequences into small molecules. [PDF]
PLoS ONE, 2012 A large body of in vitro evolution work establishes the utility of biopolymer libraries comprising 10(10) to 10(15) distinct molecules for the discovery of nanomolar-affinity ligands to proteins.
Rebecca M Weisinger +2 more
doaj +1 more source
Journal of Cheminformatics, 2023 Ultra-large chemical libraries are reaching 10s to 100s of billions of molecules. A challenge for these libraries is to efficiently check if a proposed molecule is present. Here we propose and study Bloom filters for testing if a molecule is present in a
Jorge Medina, Andrew D. White
doaj +1 more source
Directed Chemical Evolution with an Outsized Genetic Code. [PDF]
PLoS ONE, 2016 The first demonstration that macromolecules could be evolved in a test tube was reported twenty-five years ago. That breakthrough meant that billions of years of chance discovery and refinement could be compressed into a few weeks, and provided a ...
Casey J Krusemark +3 more
doaj +1 more source
Nature Communications, 2022 Chemical libraries with skeleton diversity are important for drug discovery. Here, the authors establish a synthetic methodology-based compound library (SMBL), and apply it to identify a small-molecule inhibitor to interrupt a challenging target: the ...
Jing Gu +10 more
doaj +1 more source
Completion of a programmable DNA-binding small molecule library [PDF]
Tetrahedron, 2007 Hairpin pyrrole-imidazole (Py-Im) polyamides are programmable oligomers that bind the DNA minor groove in a sequence-specific manner with affinities comparable to those of natural DNA-binding proteins. These cell-permeable small molecules have been shown to enter the nuclei of live cells and downregulate endogenous gene expression.
Hsu, Carey F. +9 more
openaire +3 more sources
Química Nova, 2001 Combinatorial Chemistry has become a very efficient methodology in drug research. Recent progress in combinatorial synthesis performed both in solid and solution phase have led to a change in the paradigm for the identification and optimization of lead ...
Ricardo L. Araújo Dias +1 more
doaj +1 more source
Impact of DNA-Encoded Chemical Library Technology on Drug Discovery
CHIMIA, 2022 DNA-Encoded Chemical Libraries (DELs) have gained momentum over the recent years for the discovery of small-molecule ligands and the technology has been integrated in most of the larger pharmaceutical companies.
Michelle Keller +2 more
doaj +1 more source