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User-focused strategic services for technological university libraries
, 2012 openaire +1 more source
Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library
Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Libraryopenaire
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LoFT: Similarity-Driven Multiobjective Focused Library Design
Journal of Chemical Information and Modeling, 2010We present LoFT, a tool for focused combinatorial library design. LoFT provides a set of algorithms, constructing a focused library from a chemical fragment space under optimization of multiple design criteria. A weighted multiobjective scoring function based on physicochemical descriptors is employed for traversing the chemical search space.
J. Fischer, U. Lessel, M. Rarey
semanticscholar +3 more sources
A focused library of protein tyrosine phosphatase inhibitors.
Journal of Medicinal Chemistry, 2010Protein tyrosine phosphatases such as PTP1B and YopH are potential targets for the development of therapeutic agents against a variety of pathological conditions including diabetes, obesity, and infection by the bacterium Yersinia pestis. A focused library of bidentate α-ketoacid-based inhibitors has been screened against several tyrosine phosphatases.
Anthony B. Comeau +3 more
semanticscholar +3 more sources
, 2009
A top library consultant offers specific recommendations for helping libraries adapt to their changing role in the community. What is the future of the public library?
Joseph R. Matthews
semanticscholar +2 more sources
A top library consultant offers specific recommendations for helping libraries adapt to their changing role in the community. What is the future of the public library?
Joseph R. Matthews
semanticscholar +2 more sources
Ratiometric fluorescent probes for hydrogen peroxide from a focused library.
Chemistry – A European Journal, 201310.1002/chem.201302523 ; Chemistry - A European Journal ; 19 ; 44 ; 14791-14794 ...
Sang Wook Lee +3 more
semanticscholar +4 more sources
Targeting tuberculosis through a small focused library of 1,2,3-triazoles
Molecular Diversity, 2011Looking for new active molecules against Mycobacterium tuberculosis, a small focused library of 1,2,3-triazoles was efficiently prepared by click chemistry. Compounds were subsequently tested against different pathogenic and opportunistic mycobacteria including M. avium and M. tuberculosis.
G. Labadié +2 more
semanticscholar +3 more sources