Results 261 to 270 of about 11,077,430 (333)

Multifunctional multivalency: a focused library of polymeric cholera toxin antagonists.

Organic & Biomolecular Chemistry, 2011
Structural pre-organization of the multivalent ligands is important for successful interaction with multimeric proteins. Polymer-based heterobifunctional ligands that contain pendant groups prearranged into heterodimers can be used to probe the active site and surrounding area of the receptor.
Huu-Anh Tran, P. Kitov, E. Paszkiewicz, J. Sadowska, D. Bundle   +4 more
semanticscholar   +3 more sources

Building a Focused Library

Genetic Engineering & Biotechnology News, 2012
M. Slater, Katriona Scoffin
semanticscholar   +2 more sources

Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation.

Journal of Medicinal Chemistry, 2023
Histone deacetylase 1 and 2 (HDAC1/2) inhibitors are potentially useful as tools for probing the biological functions of the isoforms and as therapeutic agents for cancer and neurodegenerative disorders.
Yukihiro Itoh, Peng Zhan, Toshifumi Tojo, Pattaporn Jaikhan, Yosuke Ota, Miki Suzuki, Ying Li, Zi Hui, Yukiko Moriyama, Yuri Takada, Yasunobu Yamashita, Makoto Oba, Shusaku Uchida, Mitsuharu Masuda, Shinji Ito, Yoshihiro Sowa, Toshiyuki Sakai, Takayoshi Suzuki   +17 more
semanticscholar   +1 more source

Photochemical synthesis of an epigenetic focused tetrahydroquinoline library

RSC Medicinal Chemistry, 2021
This work describes the photochemical synthesis of a tetrahydroquinoline library enriched with chemotypes privileged for epigenetic targets and exploring new regions of chemical space.
Adam I. Green, George M. Burslem
openaire   +2 more sources

Focused chemistry from annotated libraries

Drug Discovery Today: Technologies, 2006
Annotated compound libraries have emerged as an interesting phenomenon in drug discovery in the post-genomic era. The underlying strategy behind selection of these biased libraries is to bring together information pertaining to the relationships between biological targets, respective small-molecule ligands and their biological functions in a single ...
Konstantin V. Balakin, Sergey E. Tkachenko, Alexander S. Kiselyov, Nikolay P. Savchuk   +3 more
openaire   +1 more source

A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential.

ACS Chemical Neuroscience, 2018
Overcoming the lack of effective treatments and the continuous clinical trial failures in neurodegenerative drug discovery might require a shift from the prevailing paradigm targeting pathogenesis to the one targeting simultaneously neuroprotection and ...
Elisa Uliassi, Luis Emiliano Peña-Altamira, A. V. Morales, F. Massenzio, Sabrina Petralla, Michele Rossi, M. Roberti, Loreto Martínez González, Ana Martínez, Barbara Monti, M. Bolognesi   +10 more
semanticscholar   +1 more source

A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes.

Journal of the American Chemical Society, 2019
DNA-encoded chemical libraries are increasingly used in pharmaceutical research because they enable the rapid discovery of synthetic protein ligands. Here we explored whether target-class focused DNA-encoded chemical libraries can be cost-effective tools
Lik Hang Yuen, Srikanta Dana, Yu Liu, Samuel I. Bloom, A. Thorsell, D. Neri, A. Donato, D. Kireev, H. Schüler, R. Franzini   +9 more
semanticscholar   +1 more source

Critical success factors for digital library implementation in Africa: Solution focused rather than problem focused

Information Development, 2020
Digital libraries continue to be an important source for indigenous content and research output in developing countries, especially in the context where traditional distribution mechanisms failed. It is therefore useful for continual research to maintain
Feria Wirba Singeh, A. Abdullah, K. Kaur
semanticscholar   +1 more source

Public Libraries: Focusing on the 1990s

Library Review, 1989
The literature is reviewed to show likely future trends of public library services in the USA. The role of libraries, the nature of users, library buildings and charges for library services are all examined and general conclusions drawn.
L.B. Woods, Jennifer Greenstreet, Janet Lee, Donna Hogan, Travis Rickman   +4 more
openaire   +1 more source

Adaptive Combinatorial Design of Focused Compound Libraries

2009
Low-throughput screening for bioactive substances often represents the only way to discover new ligands of a drug target. This limits the number of compounds that can be tested for bioactivity. In such a situation, the design of small, focused compound libraries provides an alternative to the concept of large, maximally diverse screening collections ...
Gisbert, Schneider, Andreas, Schüller
openaire   +2 more sources