Results 21 to 30 of about 11,077,430 (333)

Expanding the Structural Diversity of DNA Methyltransferase Inhibitors

Pharmaceuticals, 2020
Inhibitors of DNA methyltransferases (DNMTs) are attractive compounds for epigenetic drug discovery. They are also chemical tools to understand the biochemistry of epigenetic processes. Herein, we report five distinct inhibitors of DNMT1 characterized in
K. Eurídice Juárez-Mercado, Fernando D. Prieto-Martínez, Norberto Sánchez-Cruz, Andrea Peña-Castillo, Diego Prada-Gracia, José L. Medina-Franco   +5 more
doaj   +1 more source

Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins

Molecules, 2020
Chromatin structure and function, and consequently cellular phenotype, is regulated in part by a network of chromatin-modifying enzymes that place post-translational modifications (PTMs) on histone tails.
Justin M. Rectenwald, Shiva Krishna Reddy Guduru, Zhao Dang, Leonard B. Collins, Yi-En Liao, Jacqueline L. Norris-Drouin, Stephanie H. Cholensky, Kyle W. Kaufmann, Scott M. Hammond, Dmitri B. Kireev, Stephen V. Frye, Kenneth H. Pearce   +11 more
doaj   +1 more source

Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library [PDF]

Cell Chemical Biology, 2020
Pharmacophore-focused chemical libraries are continuously being created in drug discovery programs, yet screening assays to maximize the usage of such libraries are not fully explored. Here, we report a chemical proteomics approach to reutilizing a focused chemical library of 1,800 indole-containing molecules for discovering uncharacterized ligand ...
Louvy Lynn, Punzalan, Lulu, Jiang, Di, Mao, Amarjyoti Das, Mahapatra, Shinichi, Sato, Yasushi, Takemoto, Mari, Tsujimura, Kosuke, Kusamori, Makiya, Nishikawa, Lu, Zhou, Motonari, Uesugi   +10 more
openaire   +2 more sources

Combination of 2D/3D Ligand-Based Similarity Search in Rapid Virtual Screening from Multimillion Compound Repositories. Selection and Biological Evaluation of Potential PDE4 and PDE5 Inhibitors

Molecules, 2014
Rapid in silico selection of target focused libraries from commercial repositories is an attractive and cost effective approach. If structures of active compounds are available rapid 2D similarity search can be performed on multimillion compound ...
Krisztina Dobi, István Hajdú, Beáta Flachner, Gabriella Fabó, Mária Szaszkó, Melinda Bognár, Csaba Magyar, István Simon, Dániel Szisz, Zsolt Lőrincz, Sándor Cseh, György Dormán   +11 more
doaj   +1 more source

Teaching about teaching and instruction on instruction: A challenge for health sciences library education [PDF]

, 2012
Objective: This is a review of the master's-level curricula of the fifty-eight America Library Association-accredited library and information science programs and iSchools for evidence of coursework and content related to library instruction.
Detlefsen, EG
core   +1 more source

Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library.

ACS Chemical Biology, 2020
Cereblon (CRBN) is an E3 ligase adapter protein that can be reprogrammed by imide-class compounds such as thalidomide, lenalidomide, and pomalidomide to induce the degradation of neo-substrate proteins. In order to identify additional small molecule CRBN
Chelsea E. Powell, Guangyan Du, Jianwei Che, Zhixiang He, K. Donovan, Hong Yue, Eric S. Wang, R. Nowak, Tinghu Zhang, E. Fischer, N. Gray   +10 more
semanticscholar   +1 more source

Composition and applications of focus libraries to phenotypic assays

Frontiers in Pharmacology, 2014
The wealth of bioactivity information now available on low-molecular weight compounds has enabled a paradigm shift in chemical biology and early phase drug discovery efforts.
Anne Mai eWassermann, Luiz Miguel Camargo, Douglas S. Auld   +2 more
doaj   +1 more source

Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance To rapidly identify small-molecule lead compounds to target healthcare-associated proteases, we constructed a unique 9.8-million-membered protease-focused DNA-encoded chemical library.
Surendra Dawadi, Nicholas Simmons, Gabriella Miklóssy, K. Bohren, J. Faver, M. N. Ucisik, Pranavanand Nyshadham, Zhifeng Yu, M. Matzuk   +8 more
semanticscholar   +1 more source

Service Quality Assessment with LibQUAL+® in Challenging Times: LibQUAL+® at Cranfield University [PDF]

, 2010
Cranfield University is the UK’s only wholly postgraduate university focused on science, technology, engineering, and management. The University Library first implemented the LibQUAL+® survey methodology in 2003 as a member of the Society of College ...
Killick, Selena
core   +1 more source

Focusing the library on the reader

IASL Annual Conference Proceedings, 2021
This study examined the effect of orientating library programming around the reading of manga by special education students in a secondary school. Data was collected through observation, student and teacher interviews, and videotaping student discussions of two novels.
openaire   +2 more sources