Results 291 to 300 of about 11,077,430 (333)

Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach.

Journal of Medicinal Chemistry, 2012
Tomomi Kosugi, D. R. Mitchell, A. Fujino, M. Imai, M. Kambe, Shinji Kobayashi, Hiroaki Makino, Yohei Matsueda, Y. Oue, Kanji Komatsu, Kei Imaizumi, Yuri Sakai, S. Sugiura, Osami Takenouchi, Gen Unoki, Y. Yamakoshi, Vicky Cunliffe, J. Frearson, Richard Gordon, C. Harris, H. Kalloo-Hosein, Joelle Le, G. Patel, D. J. Simpson, B. Sherborne, Peter S. Thomas, N. Suzuki, M. Takimoto-Kamimura, K. Kataoka   +28 more
semanticscholar   +1 more source

Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning

Nature Biotechnology, 2021
Luke W Koblan, Max W Shen, Jeffrey A Hussmann   +2 more
exaly  

An all-in-one nanoprinting approach for the synthesis of a nanofilm library for unclonable anti-counterfeiting applications

Nature Nanotechnology, 2023
Nadezda Tarakina, Felix F Loeffler
exaly  

Synthesis of a drug-like focused library of trisubstituted pyrrolidines using integrated flow chemistry and batch methods.

ACS Combinatorial Science, 2011
M. Baumann, I. Baxendale, Christoph Kuratli, S. Ley, Rainer E. Martin, J. Schneider   +5 more
semanticscholar   +1 more source

MaxDIA enables library-based and library-free data-independent acquisition proteomics

Nature Biotechnology, 2021
Pavel Sinitcyn, Hamid Hamzeiy, Frank McCarthy   +2 more
exaly  

Pharmacophore modeling methods in focused library selection - applications in the context of a new classification scheme.

Combinatorial chemistry & high throughput screening, 2011
T. Luu, N. Malcolm, K. Nadassy
semanticscholar   +1 more source

Array programming with NumPy

Nature, 2020
K Jarrod Millman, Stéfan J Van Der Walt, Ralf Gommers   +2 more
exaly  

On various metrics used for validation of predictive QSAR models with applications in virtual screening and focused library design.

Combinatorial chemistry & high throughput screening, 2011
K. Roy, I. Mitra
semanticscholar   +1 more source

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

Nature, 2007
Frank Schnorrer, Africa Couto, Barry J Dickson   +2 more
exaly  

Trends in kinase selectivity: insights for target class-focused library screening.

Journal of Medicinal Chemistry, 2011
Shana L. Posy, M. Hermsmeier, Wayne Vaccaro, K. Ott, G. Todderud, J. Lippy, G. Trainor, D. Loughney, Stephen R. Johnson   +8 more
semanticscholar   +1 more source